Aberrations in hemostasis and coagulation in untreated discordant hepatic xenotransplantation: Studies in the dog-to-pig model

A. Joseph Tector, Jonathan A. Fridell, Nahel Elias, Taichi Watanabe, Julie Salazar, Doris Greinke, Peter Metrakos, Jean I. Tchervenkov

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Discordant liver xenotransplantation is a poorly explored entity. Data from the few large animal studies of hepatic xenotransplantation suggest that severe hemorrhage is encountered. The purpose of the studies described here is to characterize the nature of the hemorrhage that accompanies liver xenotransplantation. Canine livers were transplanted into porcine recipients, and lethal hemorrhage was encountered. Analysis of recipient blood showed that factors V, IX, and X were present in adequate levels until after the hemorrhage appeared, suggesting that coagulation factor loss was the result and not the cause of hemorrhage. Platelet counts decreased dramatically in recipients within minutes of graft reperfusion. There also was no evidence of clotting activity in the blood of recipients of liver xenografts within minutes of graft reperfusion. This loss of clotting activity was specific to liver xenografts, was not seen in renal xenografts with or without venovenous bypass, and also was absent in pig-to-pig liver allografts. In brief, the hemorrhage that accompanies liver xenotransplantation occurs because of a decrease in the number and function of circulating platelets in the recipient.

Original languageEnglish
Pages (from-to)153-159
Number of pages7
JournalLiver Transplantation
Volume8
Issue number2
DOIs
StatePublished - 2002

Fingerprint

Heterologous Transplantation
Hemostasis
Swine
Dogs
Liver
Hemorrhage
Heterografts
Reperfusion
Transplants
Factor X
Factor IX
Blood Coagulation Factors
Factor V
Platelet Count
Allografts
Canidae
Blood Platelets
Kidney

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Tector, A. J., Fridell, J. A., Elias, N., Watanabe, T., Salazar, J., Greinke, D., ... Tchervenkov, J. I. (2002). Aberrations in hemostasis and coagulation in untreated discordant hepatic xenotransplantation: Studies in the dog-to-pig model. Liver Transplantation, 8(2), 153-159. https://doi.org/10.1053/jlts.2002.30881

Aberrations in hemostasis and coagulation in untreated discordant hepatic xenotransplantation : Studies in the dog-to-pig model. / Tector, A. Joseph; Fridell, Jonathan A.; Elias, Nahel; Watanabe, Taichi; Salazar, Julie; Greinke, Doris; Metrakos, Peter; Tchervenkov, Jean I.

In: Liver Transplantation, Vol. 8, No. 2, 2002, p. 153-159.

Research output: Contribution to journalArticle

Tector, AJ, Fridell, JA, Elias, N, Watanabe, T, Salazar, J, Greinke, D, Metrakos, P & Tchervenkov, JI 2002, 'Aberrations in hemostasis and coagulation in untreated discordant hepatic xenotransplantation: Studies in the dog-to-pig model', Liver Transplantation, vol. 8, no. 2, pp. 153-159. https://doi.org/10.1053/jlts.2002.30881
Tector, A. Joseph ; Fridell, Jonathan A. ; Elias, Nahel ; Watanabe, Taichi ; Salazar, Julie ; Greinke, Doris ; Metrakos, Peter ; Tchervenkov, Jean I. / Aberrations in hemostasis and coagulation in untreated discordant hepatic xenotransplantation : Studies in the dog-to-pig model. In: Liver Transplantation. 2002 ; Vol. 8, No. 2. pp. 153-159.
@article{e6e96cd10f0c4ab2b885feea297695c6,
title = "Aberrations in hemostasis and coagulation in untreated discordant hepatic xenotransplantation: Studies in the dog-to-pig model",
abstract = "Discordant liver xenotransplantation is a poorly explored entity. Data from the few large animal studies of hepatic xenotransplantation suggest that severe hemorrhage is encountered. The purpose of the studies described here is to characterize the nature of the hemorrhage that accompanies liver xenotransplantation. Canine livers were transplanted into porcine recipients, and lethal hemorrhage was encountered. Analysis of recipient blood showed that factors V, IX, and X were present in adequate levels until after the hemorrhage appeared, suggesting that coagulation factor loss was the result and not the cause of hemorrhage. Platelet counts decreased dramatically in recipients within minutes of graft reperfusion. There also was no evidence of clotting activity in the blood of recipients of liver xenografts within minutes of graft reperfusion. This loss of clotting activity was specific to liver xenografts, was not seen in renal xenografts with or without venovenous bypass, and also was absent in pig-to-pig liver allografts. In brief, the hemorrhage that accompanies liver xenotransplantation occurs because of a decrease in the number and function of circulating platelets in the recipient.",
author = "Tector, {A. Joseph} and Fridell, {Jonathan A.} and Nahel Elias and Taichi Watanabe and Julie Salazar and Doris Greinke and Peter Metrakos and Tchervenkov, {Jean I.}",
year = "2002",
doi = "10.1053/jlts.2002.30881",
language = "English",
volume = "8",
pages = "153--159",
journal = "Liver Transplantation",
issn = "1527-6465",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

TY - JOUR

T1 - Aberrations in hemostasis and coagulation in untreated discordant hepatic xenotransplantation

T2 - Studies in the dog-to-pig model

AU - Tector, A. Joseph

AU - Fridell, Jonathan A.

AU - Elias, Nahel

AU - Watanabe, Taichi

AU - Salazar, Julie

AU - Greinke, Doris

AU - Metrakos, Peter

AU - Tchervenkov, Jean I.

PY - 2002

Y1 - 2002

N2 - Discordant liver xenotransplantation is a poorly explored entity. Data from the few large animal studies of hepatic xenotransplantation suggest that severe hemorrhage is encountered. The purpose of the studies described here is to characterize the nature of the hemorrhage that accompanies liver xenotransplantation. Canine livers were transplanted into porcine recipients, and lethal hemorrhage was encountered. Analysis of recipient blood showed that factors V, IX, and X were present in adequate levels until after the hemorrhage appeared, suggesting that coagulation factor loss was the result and not the cause of hemorrhage. Platelet counts decreased dramatically in recipients within minutes of graft reperfusion. There also was no evidence of clotting activity in the blood of recipients of liver xenografts within minutes of graft reperfusion. This loss of clotting activity was specific to liver xenografts, was not seen in renal xenografts with or without venovenous bypass, and also was absent in pig-to-pig liver allografts. In brief, the hemorrhage that accompanies liver xenotransplantation occurs because of a decrease in the number and function of circulating platelets in the recipient.

AB - Discordant liver xenotransplantation is a poorly explored entity. Data from the few large animal studies of hepatic xenotransplantation suggest that severe hemorrhage is encountered. The purpose of the studies described here is to characterize the nature of the hemorrhage that accompanies liver xenotransplantation. Canine livers were transplanted into porcine recipients, and lethal hemorrhage was encountered. Analysis of recipient blood showed that factors V, IX, and X were present in adequate levels until after the hemorrhage appeared, suggesting that coagulation factor loss was the result and not the cause of hemorrhage. Platelet counts decreased dramatically in recipients within minutes of graft reperfusion. There also was no evidence of clotting activity in the blood of recipients of liver xenografts within minutes of graft reperfusion. This loss of clotting activity was specific to liver xenografts, was not seen in renal xenografts with or without venovenous bypass, and also was absent in pig-to-pig liver allografts. In brief, the hemorrhage that accompanies liver xenotransplantation occurs because of a decrease in the number and function of circulating platelets in the recipient.

UR - http://www.scopus.com/inward/record.url?scp=0036192416&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036192416&partnerID=8YFLogxK

U2 - 10.1053/jlts.2002.30881

DO - 10.1053/jlts.2002.30881

M3 - Article

C2 - 11862592

AN - SCOPUS:0036192416

VL - 8

SP - 153

EP - 159

JO - Liver Transplantation

JF - Liver Transplantation

SN - 1527-6465

IS - 2

ER -