Abnormal angular gyrus asymmetry in schizophrenia

Margaret Niznikiewicz, Robert Donnino, Robert W. McCarley, Paul G. Nestor, Daniel V. Iosifescu, Brian O'Donnell, James Levitt, Martha E. Shenton

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Objective: Few studies have evaluated the parietal lobe in schizophrenia despite the fact that it has an important role in attention, memory, and language - all functions that have been reported to be abnormal in schizophrenia. The inferior parietal lobule, in particular, is of interest because it is not only part of the heteromodal association cortex but also is part of the semantic-lexical network, which also includes the planum temporale. Both the inferior parietal lobule, particularly the angular gyrus of the inferior parietal lobule, and the planum temporale are brain regions that play a critical role as biological substrates of language and thought. The authors compared volume and asymmetry measures of the individual gyri of the parietal lobe by means of magnetic resonance imaging (MRI) scans. Method: MRI scans with a 1.5-Tesla magnet were obtained from 15 male chronic schizophrenic and 15 comparison subjects matched for age, gender, and parental socioeconomic status. Results: Inferior parietal lobule volumes showed a leftward asymmetry (left 7.0% larger than right) in comparison subjects and a reversed asymmetry (left 6.3% smaller than right) in schizophrenic subjects. The angular gyrus accounted for this difference in asymmetry, with the left angular gyrus being significantly larger (18.7%) than the right in comparison subjects, a finding that was not observed in schizophrenic patients. A further test of angular gyrus asymmetry showed a reversal of the normal left-greater-than-right asymmetry in the schizophrenic patients. Conclusions: Patients with schizophrenia showed a reversed asymmetry in the inferior parietal lobule that was localized to the angular gyrus, a structure belonging to the heteromodal association cortex as well as being part of the semantic-lexical network. This finding contributes to a more comprehensive understanding of the neural substrates of language and thought disorder in schizophrenia.

Original languageEnglish (US)
Pages (from-to)428-437
Number of pages10
JournalAmerican Journal of Psychiatry
Volume157
Issue number3
DOIs
StatePublished - Mar 2000
Externally publishedYes

Fingerprint

Parietal Lobe
Schizophrenia
Temazepam
Semantics
Language
Magnetic Resonance Imaging
Language Disorders
Magnets
Social Class
Parents

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Niznikiewicz, M., Donnino, R., McCarley, R. W., Nestor, P. G., Iosifescu, D. V., O'Donnell, B., ... Shenton, M. E. (2000). Abnormal angular gyrus asymmetry in schizophrenia. American Journal of Psychiatry, 157(3), 428-437. https://doi.org/10.1176/appi.ajp.157.3.428

Abnormal angular gyrus asymmetry in schizophrenia. / Niznikiewicz, Margaret; Donnino, Robert; McCarley, Robert W.; Nestor, Paul G.; Iosifescu, Daniel V.; O'Donnell, Brian; Levitt, James; Shenton, Martha E.

In: American Journal of Psychiatry, Vol. 157, No. 3, 03.2000, p. 428-437.

Research output: Contribution to journalArticle

Niznikiewicz, M, Donnino, R, McCarley, RW, Nestor, PG, Iosifescu, DV, O'Donnell, B, Levitt, J & Shenton, ME 2000, 'Abnormal angular gyrus asymmetry in schizophrenia', American Journal of Psychiatry, vol. 157, no. 3, pp. 428-437. https://doi.org/10.1176/appi.ajp.157.3.428
Niznikiewicz M, Donnino R, McCarley RW, Nestor PG, Iosifescu DV, O'Donnell B et al. Abnormal angular gyrus asymmetry in schizophrenia. American Journal of Psychiatry. 2000 Mar;157(3):428-437. https://doi.org/10.1176/appi.ajp.157.3.428
Niznikiewicz, Margaret ; Donnino, Robert ; McCarley, Robert W. ; Nestor, Paul G. ; Iosifescu, Daniel V. ; O'Donnell, Brian ; Levitt, James ; Shenton, Martha E. / Abnormal angular gyrus asymmetry in schizophrenia. In: American Journal of Psychiatry. 2000 ; Vol. 157, No. 3. pp. 428-437.
@article{0600d47ed68040d68ca8351cfb89623d,
title = "Abnormal angular gyrus asymmetry in schizophrenia",
abstract = "Objective: Few studies have evaluated the parietal lobe in schizophrenia despite the fact that it has an important role in attention, memory, and language - all functions that have been reported to be abnormal in schizophrenia. The inferior parietal lobule, in particular, is of interest because it is not only part of the heteromodal association cortex but also is part of the semantic-lexical network, which also includes the planum temporale. Both the inferior parietal lobule, particularly the angular gyrus of the inferior parietal lobule, and the planum temporale are brain regions that play a critical role as biological substrates of language and thought. The authors compared volume and asymmetry measures of the individual gyri of the parietal lobe by means of magnetic resonance imaging (MRI) scans. Method: MRI scans with a 1.5-Tesla magnet were obtained from 15 male chronic schizophrenic and 15 comparison subjects matched for age, gender, and parental socioeconomic status. Results: Inferior parietal lobule volumes showed a leftward asymmetry (left 7.0{\%} larger than right) in comparison subjects and a reversed asymmetry (left 6.3{\%} smaller than right) in schizophrenic subjects. The angular gyrus accounted for this difference in asymmetry, with the left angular gyrus being significantly larger (18.7{\%}) than the right in comparison subjects, a finding that was not observed in schizophrenic patients. A further test of angular gyrus asymmetry showed a reversal of the normal left-greater-than-right asymmetry in the schizophrenic patients. Conclusions: Patients with schizophrenia showed a reversed asymmetry in the inferior parietal lobule that was localized to the angular gyrus, a structure belonging to the heteromodal association cortex as well as being part of the semantic-lexical network. This finding contributes to a more comprehensive understanding of the neural substrates of language and thought disorder in schizophrenia.",
author = "Margaret Niznikiewicz and Robert Donnino and McCarley, {Robert W.} and Nestor, {Paul G.} and Iosifescu, {Daniel V.} and Brian O'Donnell and James Levitt and Shenton, {Martha E.}",
year = "2000",
month = "3",
doi = "10.1176/appi.ajp.157.3.428",
language = "English (US)",
volume = "157",
pages = "428--437",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "3",

}

TY - JOUR

T1 - Abnormal angular gyrus asymmetry in schizophrenia

AU - Niznikiewicz, Margaret

AU - Donnino, Robert

AU - McCarley, Robert W.

AU - Nestor, Paul G.

AU - Iosifescu, Daniel V.

AU - O'Donnell, Brian

AU - Levitt, James

AU - Shenton, Martha E.

PY - 2000/3

Y1 - 2000/3

N2 - Objective: Few studies have evaluated the parietal lobe in schizophrenia despite the fact that it has an important role in attention, memory, and language - all functions that have been reported to be abnormal in schizophrenia. The inferior parietal lobule, in particular, is of interest because it is not only part of the heteromodal association cortex but also is part of the semantic-lexical network, which also includes the planum temporale. Both the inferior parietal lobule, particularly the angular gyrus of the inferior parietal lobule, and the planum temporale are brain regions that play a critical role as biological substrates of language and thought. The authors compared volume and asymmetry measures of the individual gyri of the parietal lobe by means of magnetic resonance imaging (MRI) scans. Method: MRI scans with a 1.5-Tesla magnet were obtained from 15 male chronic schizophrenic and 15 comparison subjects matched for age, gender, and parental socioeconomic status. Results: Inferior parietal lobule volumes showed a leftward asymmetry (left 7.0% larger than right) in comparison subjects and a reversed asymmetry (left 6.3% smaller than right) in schizophrenic subjects. The angular gyrus accounted for this difference in asymmetry, with the left angular gyrus being significantly larger (18.7%) than the right in comparison subjects, a finding that was not observed in schizophrenic patients. A further test of angular gyrus asymmetry showed a reversal of the normal left-greater-than-right asymmetry in the schizophrenic patients. Conclusions: Patients with schizophrenia showed a reversed asymmetry in the inferior parietal lobule that was localized to the angular gyrus, a structure belonging to the heteromodal association cortex as well as being part of the semantic-lexical network. This finding contributes to a more comprehensive understanding of the neural substrates of language and thought disorder in schizophrenia.

AB - Objective: Few studies have evaluated the parietal lobe in schizophrenia despite the fact that it has an important role in attention, memory, and language - all functions that have been reported to be abnormal in schizophrenia. The inferior parietal lobule, in particular, is of interest because it is not only part of the heteromodal association cortex but also is part of the semantic-lexical network, which also includes the planum temporale. Both the inferior parietal lobule, particularly the angular gyrus of the inferior parietal lobule, and the planum temporale are brain regions that play a critical role as biological substrates of language and thought. The authors compared volume and asymmetry measures of the individual gyri of the parietal lobe by means of magnetic resonance imaging (MRI) scans. Method: MRI scans with a 1.5-Tesla magnet were obtained from 15 male chronic schizophrenic and 15 comparison subjects matched for age, gender, and parental socioeconomic status. Results: Inferior parietal lobule volumes showed a leftward asymmetry (left 7.0% larger than right) in comparison subjects and a reversed asymmetry (left 6.3% smaller than right) in schizophrenic subjects. The angular gyrus accounted for this difference in asymmetry, with the left angular gyrus being significantly larger (18.7%) than the right in comparison subjects, a finding that was not observed in schizophrenic patients. A further test of angular gyrus asymmetry showed a reversal of the normal left-greater-than-right asymmetry in the schizophrenic patients. Conclusions: Patients with schizophrenia showed a reversed asymmetry in the inferior parietal lobule that was localized to the angular gyrus, a structure belonging to the heteromodal association cortex as well as being part of the semantic-lexical network. This finding contributes to a more comprehensive understanding of the neural substrates of language and thought disorder in schizophrenia.

UR - http://www.scopus.com/inward/record.url?scp=0034099210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034099210&partnerID=8YFLogxK

U2 - 10.1176/appi.ajp.157.3.428

DO - 10.1176/appi.ajp.157.3.428

M3 - Article

VL - 157

SP - 428

EP - 437

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 3

ER -