Abnormal colony formation and prostaglandin E responsiveness of myeloid progenitor cells in patients cured of germ cell neoplasms after combination chemotherapy

S. P. Leitner, G. J. Bosl, Louis Pelus

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Myelopoiesis was evaluated in 16 patients in complete remission for a minimum of 9 months after treatment with cisplatin-based combination chemotherapy for metastatic germ cell tumors. None had overt hematopoietic abnormalities. Bone marrow aspirates were obtained for routine morphologic evaluation in seven patients, and myeloid precursor cells were studied for both colony/cluster formation and sensitivity to prostaglandin E-(PGE) mediated growth inhibition in 13 patients. Routine stained marrow smears appeared normal. Six of 13 patients demonstrated abnormal colony/cluster formation. Four patients had no colony formation at all. Ten of 12 patients showed decreased sensitivity of granulocyte-macrophage colony-forming (CFU-GM) to PGE inhibition. The studies suggest that defects in myelopoiesis are detectable in patients treated for germ cell tumors with combination chemotherapy. The clinical significance of these findings requires long-term follow-up and surveillance for overt hematopoietic abnormalities in survivors of testicular cancer.

Original languageEnglish (US)
Pages (from-to)312-317
Number of pages6
JournalCancer
Volume60
Issue number3
StatePublished - 1987
Externally publishedYes

Fingerprint

Myeloid Progenitor Cells
Germ Cell and Embryonal Neoplasms
Prostaglandins E
Combination Drug Therapy
Myelopoiesis
Bone Marrow
Granulocyte-Macrophage Progenitor Cells
Testicular Neoplasms
Myeloid Cells
Granulocytes
Cisplatin
Survivors
Macrophages
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Abnormal colony formation and prostaglandin E responsiveness of myeloid progenitor cells in patients cured of germ cell neoplasms after combination chemotherapy. / Leitner, S. P.; Bosl, G. J.; Pelus, Louis.

In: Cancer, Vol. 60, No. 3, 1987, p. 312-317.

Research output: Contribution to journalArticle

@article{7dfca231061545a1884f83e11a5c2e55,
title = "Abnormal colony formation and prostaglandin E responsiveness of myeloid progenitor cells in patients cured of germ cell neoplasms after combination chemotherapy",
abstract = "Myelopoiesis was evaluated in 16 patients in complete remission for a minimum of 9 months after treatment with cisplatin-based combination chemotherapy for metastatic germ cell tumors. None had overt hematopoietic abnormalities. Bone marrow aspirates were obtained for routine morphologic evaluation in seven patients, and myeloid precursor cells were studied for both colony/cluster formation and sensitivity to prostaglandin E-(PGE) mediated growth inhibition in 13 patients. Routine stained marrow smears appeared normal. Six of 13 patients demonstrated abnormal colony/cluster formation. Four patients had no colony formation at all. Ten of 12 patients showed decreased sensitivity of granulocyte-macrophage colony-forming (CFU-GM) to PGE inhibition. The studies suggest that defects in myelopoiesis are detectable in patients treated for germ cell tumors with combination chemotherapy. The clinical significance of these findings requires long-term follow-up and surveillance for overt hematopoietic abnormalities in survivors of testicular cancer.",
author = "Leitner, {S. P.} and Bosl, {G. J.} and Louis Pelus",
year = "1987",
language = "English (US)",
volume = "60",
pages = "312--317",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Abnormal colony formation and prostaglandin E responsiveness of myeloid progenitor cells in patients cured of germ cell neoplasms after combination chemotherapy

AU - Leitner, S. P.

AU - Bosl, G. J.

AU - Pelus, Louis

PY - 1987

Y1 - 1987

N2 - Myelopoiesis was evaluated in 16 patients in complete remission for a minimum of 9 months after treatment with cisplatin-based combination chemotherapy for metastatic germ cell tumors. None had overt hematopoietic abnormalities. Bone marrow aspirates were obtained for routine morphologic evaluation in seven patients, and myeloid precursor cells were studied for both colony/cluster formation and sensitivity to prostaglandin E-(PGE) mediated growth inhibition in 13 patients. Routine stained marrow smears appeared normal. Six of 13 patients demonstrated abnormal colony/cluster formation. Four patients had no colony formation at all. Ten of 12 patients showed decreased sensitivity of granulocyte-macrophage colony-forming (CFU-GM) to PGE inhibition. The studies suggest that defects in myelopoiesis are detectable in patients treated for germ cell tumors with combination chemotherapy. The clinical significance of these findings requires long-term follow-up and surveillance for overt hematopoietic abnormalities in survivors of testicular cancer.

AB - Myelopoiesis was evaluated in 16 patients in complete remission for a minimum of 9 months after treatment with cisplatin-based combination chemotherapy for metastatic germ cell tumors. None had overt hematopoietic abnormalities. Bone marrow aspirates were obtained for routine morphologic evaluation in seven patients, and myeloid precursor cells were studied for both colony/cluster formation and sensitivity to prostaglandin E-(PGE) mediated growth inhibition in 13 patients. Routine stained marrow smears appeared normal. Six of 13 patients demonstrated abnormal colony/cluster formation. Four patients had no colony formation at all. Ten of 12 patients showed decreased sensitivity of granulocyte-macrophage colony-forming (CFU-GM) to PGE inhibition. The studies suggest that defects in myelopoiesis are detectable in patients treated for germ cell tumors with combination chemotherapy. The clinical significance of these findings requires long-term follow-up and surveillance for overt hematopoietic abnormalities in survivors of testicular cancer.

UR - http://www.scopus.com/inward/record.url?scp=0023224851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023224851&partnerID=8YFLogxK

M3 - Article

VL - 60

SP - 312

EP - 317

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 3

ER -