Abnormal polyunsaturated lipid metabolism in the obese Zucker rat, with partial metabolic correction by γ-linolenic acid administration

Stephen D. Phinney, Anna B. Tang, Debbie C. Thurmond, Manabu T. Nakamura, Judith S. Stern

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Below-normal proportions of phospholipid (PL) arachidonic acid (20:4ω6) have been reported in serum from obese humans and in liver from obese Zucker rats. This implies an abnormality of 20:4ω6 formation from linoleic acid (18:2ω6), possibly in the Δ6 desaturase step, or alternatively an abnormality in the catabolism or distribution of arachidonate. We previously speculated that a reduced proportion of 20:4ω6 in hepatic PL could contribute to the etiology of genetic obesity. Providing 18:3ω6 would bypass Δ6 desaturase and possibly normalize hepatic PL 20:4ω6. Therefore weanling Zucker rats were given free access to a defined diet (11% of energy as soy oil) and gavaged daily with 100 μL of either black currant oil concentrate ([BCO] 8% 18:2ω6 and 70% 18:3ω6) or soy oil ([Soy] 55% 18:2ω6 and

Original languageEnglish (US)
Pages (from-to)1127-1140
Number of pages14
JournalMetabolism: Clinical and Experimental
Volume42
Issue number9
DOIs
StatePublished - 1993
Externally publishedYes

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Zucker Rats
alpha-Linolenic Acid
Lipid Metabolism
Phospholipids
Liver
Oils
Linoleic Acid
Arachidonic Acid
Obesity
Diet
Serum

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Abnormal polyunsaturated lipid metabolism in the obese Zucker rat, with partial metabolic correction by γ-linolenic acid administration. / Phinney, Stephen D.; Tang, Anna B.; Thurmond, Debbie C.; Nakamura, Manabu T.; Stern, Judith S.

In: Metabolism: Clinical and Experimental, Vol. 42, No. 9, 1993, p. 1127-1140.

Research output: Contribution to journalArticle

Phinney, Stephen D. ; Tang, Anna B. ; Thurmond, Debbie C. ; Nakamura, Manabu T. ; Stern, Judith S. / Abnormal polyunsaturated lipid metabolism in the obese Zucker rat, with partial metabolic correction by γ-linolenic acid administration. In: Metabolism: Clinical and Experimental. 1993 ; Vol. 42, No. 9. pp. 1127-1140.
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