Abnormalities in pelvic visceral nerves. A basis for neurogenic bladder in the diabetic Chinese hamster

W. G. Dail, Andrew Evan, G. C. Gerritsen, W. E. Dulin

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In order to determine whether bladder dysfunction and hydronephrosis in diabetic Chinese hamsters are associated with nerve pathology, the pelvic visceral nerves of diabetic and normal hamsters were examined with histochemical and electron microscopic techniques. Acetylcholinesterase activity was reduced in the nerves and on smooth muscle fibers in the urinary bladder of diabetic hamsters when compared to controls. Depression of enzyme staining was most marked in those hamsters with the most severe hydronephrosis. Frequent examples of aberrant myelination were found in the pelvic plexus and urinary bladder of diabetics. Many of these myelinated fibers exhibited wide periaxonal spaces lined by unusual processes of Schwann cells. An increase in the number of microtubules in axons and circular profiles of Schwann cells, which failed to enclose axons, gave evidence of axonal degeneration or Schwann cell injury in diabetic nerves. These findings suggest that pathologic changes in pelvic visceral nerves may underlie urinary bladder dysfunction in the diabetic Chinese hamster.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalInvestigative Urology
Volume15
Issue number2
StatePublished - 1977
Externally publishedYes

Fingerprint

Neurogenic Urinary Bladder
Cricetulus
Schwann Cells
Urinary Bladder
Cricetinae
Hydronephrosis
Axons
Hypogastric Plexus
Acetylcholinesterase
Microtubules
Smooth Muscle
Electrons
Pathology
Staining and Labeling
Wounds and Injuries
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Abnormalities in pelvic visceral nerves. A basis for neurogenic bladder in the diabetic Chinese hamster. / Dail, W. G.; Evan, Andrew; Gerritsen, G. C.; Dulin, W. E.

In: Investigative Urology, Vol. 15, No. 2, 1977, p. 161-166.

Research output: Contribution to journalArticle

@article{10fcd43743cc4f6fb440a6109325e5d2,
title = "Abnormalities in pelvic visceral nerves. A basis for neurogenic bladder in the diabetic Chinese hamster",
abstract = "In order to determine whether bladder dysfunction and hydronephrosis in diabetic Chinese hamsters are associated with nerve pathology, the pelvic visceral nerves of diabetic and normal hamsters were examined with histochemical and electron microscopic techniques. Acetylcholinesterase activity was reduced in the nerves and on smooth muscle fibers in the urinary bladder of diabetic hamsters when compared to controls. Depression of enzyme staining was most marked in those hamsters with the most severe hydronephrosis. Frequent examples of aberrant myelination were found in the pelvic plexus and urinary bladder of diabetics. Many of these myelinated fibers exhibited wide periaxonal spaces lined by unusual processes of Schwann cells. An increase in the number of microtubules in axons and circular profiles of Schwann cells, which failed to enclose axons, gave evidence of axonal degeneration or Schwann cell injury in diabetic nerves. These findings suggest that pathologic changes in pelvic visceral nerves may underlie urinary bladder dysfunction in the diabetic Chinese hamster.",
author = "Dail, {W. G.} and Andrew Evan and Gerritsen, {G. C.} and Dulin, {W. E.}",
year = "1977",
language = "English (US)",
volume = "15",
pages = "161--166",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Abnormalities in pelvic visceral nerves. A basis for neurogenic bladder in the diabetic Chinese hamster

AU - Dail, W. G.

AU - Evan, Andrew

AU - Gerritsen, G. C.

AU - Dulin, W. E.

PY - 1977

Y1 - 1977

N2 - In order to determine whether bladder dysfunction and hydronephrosis in diabetic Chinese hamsters are associated with nerve pathology, the pelvic visceral nerves of diabetic and normal hamsters were examined with histochemical and electron microscopic techniques. Acetylcholinesterase activity was reduced in the nerves and on smooth muscle fibers in the urinary bladder of diabetic hamsters when compared to controls. Depression of enzyme staining was most marked in those hamsters with the most severe hydronephrosis. Frequent examples of aberrant myelination were found in the pelvic plexus and urinary bladder of diabetics. Many of these myelinated fibers exhibited wide periaxonal spaces lined by unusual processes of Schwann cells. An increase in the number of microtubules in axons and circular profiles of Schwann cells, which failed to enclose axons, gave evidence of axonal degeneration or Schwann cell injury in diabetic nerves. These findings suggest that pathologic changes in pelvic visceral nerves may underlie urinary bladder dysfunction in the diabetic Chinese hamster.

AB - In order to determine whether bladder dysfunction and hydronephrosis in diabetic Chinese hamsters are associated with nerve pathology, the pelvic visceral nerves of diabetic and normal hamsters were examined with histochemical and electron microscopic techniques. Acetylcholinesterase activity was reduced in the nerves and on smooth muscle fibers in the urinary bladder of diabetic hamsters when compared to controls. Depression of enzyme staining was most marked in those hamsters with the most severe hydronephrosis. Frequent examples of aberrant myelination were found in the pelvic plexus and urinary bladder of diabetics. Many of these myelinated fibers exhibited wide periaxonal spaces lined by unusual processes of Schwann cells. An increase in the number of microtubules in axons and circular profiles of Schwann cells, which failed to enclose axons, gave evidence of axonal degeneration or Schwann cell injury in diabetic nerves. These findings suggest that pathologic changes in pelvic visceral nerves may underlie urinary bladder dysfunction in the diabetic Chinese hamster.

UR - http://www.scopus.com/inward/record.url?scp=0017592593&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017592593&partnerID=8YFLogxK

M3 - Article

C2 - 903213

AN - SCOPUS:0017592593

VL - 15

SP - 161

EP - 166

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 2

ER -