ABO blood group and susceptibility of gonococcal infection. I. Factors affecting phagocytosis of Neisseria gonorrhoeae

C. C. Blackwell, M. Kowolik, F. P. Winstanley, D. F. Kinane, D. M. Weir, J. A. Law, Y. L. Ho Wang Chok

Research output: Contribution to journalArticle

Abstract

The effect of opsonization of Neisseria gonorrhoeae by isohaemagglutinins from normal serum on attachment to human polymorphonuclear leukocytes (PMN) was investigated. No significant differences between sera from blood groups, O, A, B, or AB were found. Differences in attachment of gonococci were related to differences in lipopolysaccharide detected by sensitivity to R-type pyocines of Pseudomonas aeruginosa. Non-pilate variants of each test strain markedly stimulated nitroblue tetrazolium (NBT) reduction in PMN, but their pilate variants were essentially inactive in the NBT test.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalJournal of Clinical and Laboratory Immunology
Volume10
Issue number4
StatePublished - Jun 10 1983
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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    Blackwell, C. C., Kowolik, M., Winstanley, F. P., Kinane, D. F., Weir, D. M., Law, J. A., & Ho Wang Chok, Y. L. (1983). ABO blood group and susceptibility of gonococcal infection. I. Factors affecting phagocytosis of Neisseria gonorrhoeae. Journal of Clinical and Laboratory Immunology, 10(4), 173-178.