Absence of Peyer's patches and abnormal lymphoid architecture in chronic proliferative dermatitis (cpdm/cpdm) mice

Harm HogenEsch, Sarah Janke, Dawnalyn Boggess, John P. Sundberg

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The chronic proliferative dermatitis (cpdm) mutation causes inflammation in multiple organs, most prominently in the skin. Examination of the immune system revealed severe abnormalities in the architecture of lymphoid tissues. Peyer's patches were absent. In contrast, the spleen, lymph nodes, and nasal- associated lymphoid tissues were present. The spleen had normal numbers of T and B cells, but the spleen, lymph nodes, and nasal-associated lymphoid tissues had poorly defined follicles and lacked germinal centers and follicular dendritic cells. The marginal zone in the spleen was absent. The total concentration of serum IgG, IgA, and IgE in cpdm/cpdm mice was significantly decreased, whereas serum IgM was normal. Fecal IgA was low to undetectable in mutant mice, and the concentration of fecal IgM was increased. The titer of DNP-specific Abs following immunization with DNP- keyhole limpet hemocyanin was significantly decreased for all IgG subclasses. In contrast, T cell function appeared normal as assessed by evaluation of the contact hypersensitivity response in cpdm/cpdm mice. The cpdm mutation causes a complex phenotype that is characterized by multiorgan inflammation and the defective development of lymphoid tissues. The cpdm/cpdm mouse may be a useful model to study the factors that control the development of lymphoid tissues, in particular the Peyer's patches, and the mechanisms that control the humoral immune response.

Original languageEnglish (US)
Pages (from-to)3890-3896
Number of pages7
JournalJournal of Immunology
Volume162
Issue number7
StatePublished - Apr 1 1999
Externally publishedYes

Fingerprint

Peyer's Patches
Dermatitis
Lymphoid Tissue
Spleen
Nose
Immunoglobulin A
Immunoglobulin M
Immunoglobulin G
Lymph Nodes
Follicular Dendritic Cells
Inflammation
T-Lymphocytes
Mutation
Germinal Center
Contact Dermatitis
Humoral Immunity
Serum
Immunoglobulin E
Immune System
Immunization

ASJC Scopus subject areas

  • Immunology

Cite this

Absence of Peyer's patches and abnormal lymphoid architecture in chronic proliferative dermatitis (cpdm/cpdm) mice. / HogenEsch, Harm; Janke, Sarah; Boggess, Dawnalyn; Sundberg, John P.

In: Journal of Immunology, Vol. 162, No. 7, 01.04.1999, p. 3890-3896.

Research output: Contribution to journalArticle

HogenEsch, Harm ; Janke, Sarah ; Boggess, Dawnalyn ; Sundberg, John P. / Absence of Peyer's patches and abnormal lymphoid architecture in chronic proliferative dermatitis (cpdm/cpdm) mice. In: Journal of Immunology. 1999 ; Vol. 162, No. 7. pp. 3890-3896.
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