Absorption, Enterohepatic Circulation, and Fecal Excretion of Toxicants

J. B. Watkins, C. D. Klaassen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Enterohepatic circulation involves substances that are metabolized in the liver, excreted into the bile, and passed into the intestinal lumen where they are reabsorbed across the intestinal mucosa and returned to the liver via portal circulation. Intestinal metabolism of xenobiotics contributes to enterohepatic circulation and fecal excretion. There are several families of drug transporters that facilitate the influx and efflux from enterocytes and the influx and efflux from hepatocytes. More rational drug therapy and regulation of chemicals will be possible when more extensive information on the enterohepatic circulation of xenobiotics is available.

Original languageEnglish (US)
Title of host publicationGastrointestinal Toxicology
PublisherElsevier Inc.
Pages99-112
Number of pages14
Volume3-15
ISBN (Electronic)9780081006122
ISBN (Print)9780081006016
DOIs
StatePublished - Jan 1 2018

    Fingerprint

Keywords

  • ABC transporters
  • Bile acid transporters
  • Biliary excretion
  • Enterohepatic circulation
  • Fecal excretion
  • Hepatic uptake
  • Intestinal biotransformation
  • Intestinal excretion
  • Intestinal uptake
  • Multidrug resistance proteins
  • Organic anion-transporting peptides
  • Organic cation transporters
  • Transporters

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Watkins, J. B., & Klaassen, C. D. (2018). Absorption, Enterohepatic Circulation, and Fecal Excretion of Toxicants. In Gastrointestinal Toxicology (Vol. 3-15, pp. 99-112). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801238-3.02122-X