Absorption studies of the H2-blocker nizatidine

Mary Pat Knadler, Richard F. Bergstrom, John Callaghan, Boyd D. Obermeyer, Alan Rubin

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The absolute and relative bioavailability of nizatidine, an H2 blocker, was studied in healthy male volunteers. The absolute oral bioavailability, relative to that after intravenous administration, was 98% ± 14%. The bioavailability of single and multiple oral doses of 150 mg nizatidine was unaffected by concurrent food ingestion; nizatidine may be administered either with or without food. The relative bioavailability of nizatidine was compared when given simultaneously with placebo or Gelusil, 30 minutes after propantheline, or 60 minutes before activated charcoal. Gelusil reduced the amount of nizatidine absorbed by about 10%, charcoal reduced it by about 30%, and propantheline did not affect it.

Original languageEnglish (US)
Pages (from-to)514-520
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume42
Issue number5
StatePublished - Nov 1987

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Nizatidine
Biological Availability
Propantheline
Charcoal
Food
Intravenous Administration
Healthy Volunteers
Eating
Placebos

ASJC Scopus subject areas

  • Pharmacology

Cite this

Knadler, M. P., Bergstrom, R. F., Callaghan, J., Obermeyer, B. D., & Rubin, A. (1987). Absorption studies of the H2-blocker nizatidine. Clinical Pharmacology and Therapeutics, 42(5), 514-520.

Absorption studies of the H2-blocker nizatidine. / Knadler, Mary Pat; Bergstrom, Richard F.; Callaghan, John; Obermeyer, Boyd D.; Rubin, Alan.

In: Clinical Pharmacology and Therapeutics, Vol. 42, No. 5, 11.1987, p. 514-520.

Research output: Contribution to journalArticle

Knadler, MP, Bergstrom, RF, Callaghan, J, Obermeyer, BD & Rubin, A 1987, 'Absorption studies of the H2-blocker nizatidine', Clinical Pharmacology and Therapeutics, vol. 42, no. 5, pp. 514-520.
Knadler MP, Bergstrom RF, Callaghan J, Obermeyer BD, Rubin A. Absorption studies of the H2-blocker nizatidine. Clinical Pharmacology and Therapeutics. 1987 Nov;42(5):514-520.
Knadler, Mary Pat ; Bergstrom, Richard F. ; Callaghan, John ; Obermeyer, Boyd D. ; Rubin, Alan. / Absorption studies of the H2-blocker nizatidine. In: Clinical Pharmacology and Therapeutics. 1987 ; Vol. 42, No. 5. pp. 514-520.
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