Accelerating functional recovery after rat facial nerve injury

Effects of gonadal steroids and electrical stimulation

Laura E T Hetzler, Nijee Sharma, Lisa Tanzer, Robert D. Wurster, John Leonetti, Sam J. Marzo, Kathryn Jones, Eileen M. Foecking

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objective: We investigated the combined effects of electrical stimulation and testosterone propionate on overall recovery time in rats with extracranial crush injuries to the facial nerve. Study Design: Male rats underwent castration 3 to 5 days prior to right facial nerve crush injury and electrode implantation. Rats were randomly assigned to two groups: crush injury + testosterone or crush injury with electrical stimulation + testosterone. Recovery was assessed by daily subjective examination documenting vibrissae orientation/movement, semi-eye blink, and full eye blink. Results: Milestones of early recovery were noted to be significantly earlier in the groups with electrical stimulation, with/without testosterone. The addition of testosterone to electrical stimulation showed significant earlier return of late recovery parameters and complete overall recovery. Conclusion: Electrical stimulation may decrease cell death or promote sprouting to accelerate early recovery. Testosterone may affect the actual rate of axonal regeneration and produce acceleration in functional recovery. By targeting different stages of neural regeneration, the synergy of electrical stimulation and testosterone appears to have promise as a neurotherapeutic strategy for facial nerve injury.

Original languageEnglish (US)
Pages (from-to)62-67
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Volume139
Issue number1
DOIs
StatePublished - Jul 2008
Externally publishedYes

Fingerprint

Facial Nerve Injuries
Electric Stimulation
Testosterone
Steroids
Regeneration
Nerve Crush
Testosterone Propionate
Vibrissae
Castration
Facial Nerve
Eye Movements
Electrodes
Cell Death
Crush Injuries

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Hetzler, L. E. T., Sharma, N., Tanzer, L., Wurster, R. D., Leonetti, J., Marzo, S. J., ... Foecking, E. M. (2008). Accelerating functional recovery after rat facial nerve injury: Effects of gonadal steroids and electrical stimulation. Otolaryngology - Head and Neck Surgery, 139(1), 62-67. https://doi.org/10.1016/j.otohns.2008.02.006

Accelerating functional recovery after rat facial nerve injury : Effects of gonadal steroids and electrical stimulation. / Hetzler, Laura E T; Sharma, Nijee; Tanzer, Lisa; Wurster, Robert D.; Leonetti, John; Marzo, Sam J.; Jones, Kathryn; Foecking, Eileen M.

In: Otolaryngology - Head and Neck Surgery, Vol. 139, No. 1, 07.2008, p. 62-67.

Research output: Contribution to journalArticle

Hetzler, Laura E T ; Sharma, Nijee ; Tanzer, Lisa ; Wurster, Robert D. ; Leonetti, John ; Marzo, Sam J. ; Jones, Kathryn ; Foecking, Eileen M. / Accelerating functional recovery after rat facial nerve injury : Effects of gonadal steroids and electrical stimulation. In: Otolaryngology - Head and Neck Surgery. 2008 ; Vol. 139, No. 1. pp. 62-67.
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