Acceptability of multipurpose human papillomavirus vaccines among providers and mothers of adolescent girls: A mixed-methods study in five countries

Nadja A. Vielot, Shoshana K. Goldberg, Gregory Zimet, Sara B. Smith, Mary Anne McDonald, Silvina Ramos, Karen Morgan, Chan Joo Kim, Karin L. Richter, Merce Peris, Kevin J. Whaley, Jennifer S. Smith

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction Multipurpose vaccines (MPVs) could be formulated to prevent multiple sexually transmitted infections simultaneously. Little is known about acceptability of MPVs among vaccine health care providers (HCPs) or mothers of adolescent girls. Methods 151 adolescent vaccine providers and 118 mothers of adolescent girls aged 9–14 were recruited from five geographically-diverse countries: Argentina, Malaysia, South Africa, South Korea, and Spain. We assessed providers’ preferences for single-purpose human papillomavirus (HPV) vaccine versus MPVs (including HPV+herpes simplex virus (HSV)−2, HPV+HIV, or HPV+HSV-2+HIV) via quantitative surveys. Maternal MPV attitudes were assessed in four focus group discussions (FGDs) in each country. Results Most providers preferred MPVs over single-purpose HPV vaccination, with preference ranging from 61% in Malaysia to 96% in South Africa. HPV+HSV-2+HIV was the most preferred MPV formulation (56–82%). Overall, 53% of the mothers preferred MPVs over single-purpose HPV vaccines, with strongest support in South Africa (90%) and lowest support in South Korea (29%). Convenience and trust in the health care system were commonly-cited reasons for MPV acceptability. Safety and efficacy concerns were common barriers to accepting MPVs, though specific concerns differed by country. Across FGDs, additional safety and efficacy information on MPVs were requested, particularly from trusted sources like HCPs. Conclusions Though maternal acceptability of MPVs varied by country, MPV acceptability would be enhanced by having HCPs provide parents with additional MPV vaccine safety and efficacy information. While most providers preferred MPVs, future health behavior research should identify acceptability barriers, and targeted provider interventions should equip providers to improve vaccination discussions with parents.

Original languageEnglish (US)
Pages (from-to)126-133
Number of pages8
JournalPapillomavirus Research
Volume3
DOIs
StatePublished - Jun 1 2017

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Papillomavirus Vaccines
Vaccines
Mothers
Human Herpesvirus 2
South Africa
Health Personnel
Republic of Korea
Malaysia
HIV
Focus Groups
Safety
Vaccination
Parents
Argentina
Health Behavior

Keywords

  • Acceptability
  • Adolescents
  • Human papillomavirus
  • Multipurpose
  • Sexually transmitted infections
  • Vaccines

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Acceptability of multipurpose human papillomavirus vaccines among providers and mothers of adolescent girls : A mixed-methods study in five countries. / Vielot, Nadja A.; Goldberg, Shoshana K.; Zimet, Gregory; Smith, Sara B.; Anne McDonald, Mary; Ramos, Silvina; Morgan, Karen; Joo Kim, Chan; Richter, Karin L.; Peris, Merce; Whaley, Kevin J.; Smith, Jennifer S.

In: Papillomavirus Research, Vol. 3, 01.06.2017, p. 126-133.

Research output: Contribution to journalArticle

Vielot, NA, Goldberg, SK, Zimet, G, Smith, SB, Anne McDonald, M, Ramos, S, Morgan, K, Joo Kim, C, Richter, KL, Peris, M, Whaley, KJ & Smith, JS 2017, 'Acceptability of multipurpose human papillomavirus vaccines among providers and mothers of adolescent girls: A mixed-methods study in five countries', Papillomavirus Research, vol. 3, pp. 126-133. https://doi.org/10.1016/j.pvr.2017.04.001
Vielot, Nadja A. ; Goldberg, Shoshana K. ; Zimet, Gregory ; Smith, Sara B. ; Anne McDonald, Mary ; Ramos, Silvina ; Morgan, Karen ; Joo Kim, Chan ; Richter, Karin L. ; Peris, Merce ; Whaley, Kevin J. ; Smith, Jennifer S. / Acceptability of multipurpose human papillomavirus vaccines among providers and mothers of adolescent girls : A mixed-methods study in five countries. In: Papillomavirus Research. 2017 ; Vol. 3. pp. 126-133.
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abstract = "Introduction Multipurpose vaccines (MPVs) could be formulated to prevent multiple sexually transmitted infections simultaneously. Little is known about acceptability of MPVs among vaccine health care providers (HCPs) or mothers of adolescent girls. Methods 151 adolescent vaccine providers and 118 mothers of adolescent girls aged 9–14 were recruited from five geographically-diverse countries: Argentina, Malaysia, South Africa, South Korea, and Spain. We assessed providers’ preferences for single-purpose human papillomavirus (HPV) vaccine versus MPVs (including HPV+herpes simplex virus (HSV)−2, HPV+HIV, or HPV+HSV-2+HIV) via quantitative surveys. Maternal MPV attitudes were assessed in four focus group discussions (FGDs) in each country. Results Most providers preferred MPVs over single-purpose HPV vaccination, with preference ranging from 61{\%} in Malaysia to 96{\%} in South Africa. HPV+HSV-2+HIV was the most preferred MPV formulation (56–82{\%}). Overall, 53{\%} of the mothers preferred MPVs over single-purpose HPV vaccines, with strongest support in South Africa (90{\%}) and lowest support in South Korea (29{\%}). Convenience and trust in the health care system were commonly-cited reasons for MPV acceptability. Safety and efficacy concerns were common barriers to accepting MPVs, though specific concerns differed by country. Across FGDs, additional safety and efficacy information on MPVs were requested, particularly from trusted sources like HCPs. Conclusions Though maternal acceptability of MPVs varied by country, MPV acceptability would be enhanced by having HCPs provide parents with additional MPV vaccine safety and efficacy information. While most providers preferred MPVs, future health behavior research should identify acceptability barriers, and targeted provider interventions should equip providers to improve vaccination discussions with parents.",
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