Acceptance and commitment therapy for breast cancer survivors with fear of cancer recurrence: A 3-arm pilot randomized controlled trial

Shelley A. Johns, Patrick V. Stutz, Tasneem L. Talib, Andrea A. Cohee, Kathleen A. Beck-Coon, Linda F. Brown, Laura R. Wilhelm, Patrick O. Monahan, Michelle L. LaPradd, Victoria L. Champion, Kathy D. Miller, R. Brian Giesler

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: Fear of cancer recurrence (FCR) has a profound negative impact on quality of life (QOL) for many cancer survivors. Breast cancer survivors (BCS) are particularly vulnerable, with up to 70% reporting clinically significant FCR. To the authors' knowledge, evidence-based interventions for managing FCR are limited. Acceptance and commitment therapy (ACT) promotes psychological flexibility in managing life's stressors. The current study examined the feasibility and preliminary efficacy of group-based ACT for FCR in BCS. Methods: Post-treatment BCS (91 patients with stage I-III disease) with clinical FCR randomly were assigned to ACT (6 weekly 2-hour group sessions), survivorship education (SE; 6 weekly 2-hour group sessions), or enhanced usual care (EUC; one 30-minute group coaching session with survivorship readings). FCR severity (primary outcome) and avoidant coping, anxiety, post-traumatic stress, depression, QOL, and other FCR-related variables (secondary outcomes) were assessed at baseline (T1), after the intervention (T2), 1 month after the intervention (T3), and 6 months after the intervention (T4) using intent-to-treat analysis. Results: Satisfactory recruitment (43.8%) and retention (94.5%) rates demonstrated feasibility. Although each arm demonstrated within-group reductions in FCR severity over time, only ACT produced significant reductions at each time point compared with baseline, with between-group differences at T4 substantially favoring ACT over SE (Cohen d for effect sizes, 0.80; P <.001) and EUC (Cohen d, 0.61; P <.01). For 10 of 12 secondary outcomes, only ACT produced significant within-group reductions across all time points. By T4, significant moderate to large between-group comparisons favored ACT over SE and EUC with regard to avoidant coping, anxiety, depression, QOL, and FCR-related psychological distress. Conclusions: Group-based ACT is a feasible and promising treatment for FCR and associated outcomes in BCS that warrants testing in larger, fully powered trials.

Original languageEnglish (US)
Pages (from-to)211-218
Number of pages8
JournalCancer
Volume126
Issue number1
DOIs
StatePublished - Jan 1 2020

Keywords

  • acceptance and commitment therapy (ACT)
  • anxiety
  • breast neoplasms
  • fear
  • quality of life
  • survivorship

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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