Accuracy and Acceptability of Oral Fluid HIV Self-Testing in a General Adult Population in Kenya

Ann E. Kurth, Charles M. Cleland, Nok Chhun, John E. Sidle, Edwin Were, Violet Naanyu, Wilfred Emonyi, Stephen M. Macharia, Edwin Sang, Abraham M. Siika

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

We evaluated performance, accuracy, and acceptability parameters of unsupervised oral fluid (OF) HIV self-testing (HIVST) in a general population in western Kenya. In a prospective validation design, we enrolled 240 adults to perform rapid OF HIVST and compared results to staff administered OF and rapid fingerstick tests. All reactive, discrepant, and a proportion of negative results were confirmed with lab ELISA. Twenty participants were video-recorded conducting self-testing. All participants completed a staff administered survey before and after HIVST to assess attitudes towards OF HIVST acceptability. HIV prevalence was 14.6 %. Thirty-six of the 239 HIVSTs were invalid (15.1 %; 95 % CI 11.1–20.1 %), with males twice as likely to have invalid results as females. HIVST sensitivity was 89.7 % (95 % CI 73–98 %) and specificity was 98 % (95 % CI 89–99 %). Although sensitivity was somewhat lower than expected, there is clear interest in, and high acceptability (94 %) of OF HIV self-testing.

Original languageEnglish (US)
Pages (from-to)870-879
Number of pages10
JournalAIDS and Behavior
Volume20
Issue number4
DOIs
StatePublished - Apr 1 2016

Keywords

  • HIV
  • Oral fluid
  • Self-testing
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Kurth, A. E., Cleland, C. M., Chhun, N., Sidle, J. E., Were, E., Naanyu, V., Emonyi, W., Macharia, S. M., Sang, E., & Siika, A. M. (2016). Accuracy and Acceptability of Oral Fluid HIV Self-Testing in a General Adult Population in Kenya. AIDS and Behavior, 20(4), 870-879. https://doi.org/10.1007/s10461-015-1213-9