Accuracy and Acceptability of Oral Fluid HIV Self-Testing in a General Adult Population in Kenya

Ann E. Kurth, Charles M. Cleland, Nok Chhun, John Sidle, Edwin Were, Violet Naanyu, Wilfred Emonyi, Stephen M. Macharia, Edwin Sang, Abraham M. Siika

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27 Scopus citations

Abstract

We evaluated performance, accuracy, and acceptability parameters of unsupervised oral fluid (OF) HIV self-testing (HIVST) in a general population in western Kenya. In a prospective validation design, we enrolled 240 adults to perform rapid OF HIVST and compared results to staff administered OF and rapid fingerstick tests. All reactive, discrepant, and a proportion of negative results were confirmed with lab ELISA. Twenty participants were video-recorded conducting self-testing. All participants completed a staff administered survey before and after HIVST to assess attitudes towards OF HIVST acceptability. HIV prevalence was 14.6 %. Thirty-six of the 239 HIVSTs were invalid (15.1 %; 95 % CI 11.1–20.1 %), with males twice as likely to have invalid results as females. HIVST sensitivity was 89.7 % (95 % CI 73–98 %) and specificity was 98 % (95 % CI 89–99 %). Although sensitivity was somewhat lower than expected, there is clear interest in, and high acceptability (94 %) of OF HIV self-testing.

Original languageEnglish (US)
JournalAIDS and Behavior
DOIs
StateAccepted/In press - Oct 5 2015

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Keywords

  • HIV
  • Oral fluid
  • Self-testing
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Social Psychology

Cite this

Kurth, A. E., Cleland, C. M., Chhun, N., Sidle, J., Were, E., Naanyu, V., Emonyi, W., Macharia, S. M., Sang, E., & Siika, A. M. (Accepted/In press). Accuracy and Acceptability of Oral Fluid HIV Self-Testing in a General Adult Population in Kenya. AIDS and Behavior. https://doi.org/10.1007/s10461-015-1213-9