Acetaldehyde generating enzyme systems: Roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

31 Scopus citations

Abstract

Most acetaldehyde is generated in the liver by alcohol dehydrogenase (ADH) during ethanol metabolism. Polymorphic variants of these genes encode enzymes with altered kinetic properties, and pathophysiological effects of these variants may be mediated by accumulation of acetaldehyde. Two additional pathways of acetaldehyde generation are by the cytochrome P450 2E1 (CYP2E1) and catalase. While the amount of ethanol oxidized by these enzymes comprises a small fraction of total body ethanol clearance, the local formation of acetaldehyde by these enzymes may have important effects. Additional sources of acetaldehyde include other minor enzymes (nitric oxide synthase, other cytochrome P450s, P450 reductase, xanthine oxidoreductase) as well as non-enzymatic pathways (formation of hydroxyethyl radicals from the reaction of ethanol with hydroxyl radical, and its subsequent decomposition to acetaldehyde). Acetaldehyde may have effects locally (in the cells generating it), or when delivered to other cells by the blood stream or saliva, or by diffusion from the lumen of the gastrointestinal tract. The ultimate determinants of acetaldehyde toxicity include rates of its formation, rates of oxidation, and the capacity of cellular systems to prevent or repair chemical effects of acetaldehyde (e.g. formation of protein adducts or modification of nucleic acid bases).

Original languageEnglish (US)
Title of host publicationAcetaldehyde-Related Pathology
Subtitle of host publicationBridging the Trans-Disciplinary Divide
Pages4-16
Number of pages13
StatePublished - Dec 1 2007

Publication series

NameNovartis Foundation Symposium
Volume285
ISSN (Print)1528-2511

ASJC Scopus subject areas

  • Medicine(all)

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    Crabb, D. W., & Liangpunsakul, S. (2007). Acetaldehyde generating enzyme systems: Roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes. In Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide (pp. 4-16). (Novartis Foundation Symposium; Vol. 285).