• A wide array of conditions ultimately can lead to acid-base imbalance, and interpretation of acid-base disorders always involves a mix of art, knowledge, and clinical experience. • Solving the puzzle of acid-base disorders begins with accurate diagnosis, a process requiring two tasks. First, acid-base variables in the blood must be reliably measured to determine the effect of multiple ions and buffers. Second, the data must be interpreted in relation to human disease to define the patient's acid-base status. • History, physical examination, and additional laboratory testing and imaging help the clinician to identify the specific cause of the acid-base isturbance and to undertake appropriate intervention.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health