Acquired Cyclic Amegakaryocytic Thrombocytopenia Associated with an Immunoglobulin Blocking the Action of Granulocyte–Macrophage Colony-Stimulating Factor

Ronald Hoffman, Robert A. Briddell, Koen Van Besien, Edward F. Srour, Timothy Guscar, Norman W. Hudson, Arnol Ganser

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

INCREASING evidence over the past decade has indicated that certain patients with aplastic anemia and single-lineage deficiencies of hematopoietic cells have disorders of immunologic origin.1 2 3 Recently, a family of specific glycoproteins collectively known as colony-stimulating factors, which interact to control the differentiation of hematopoietic cells, have been identified, purified, and cloned.4 5 6 Granulocyte–macrophage colony-stimulating factor (GM-CSF) stimulates the development of megakaryocyte colony-forming units (CFU-MK) as well as granulocytes and macrophages. We report evidence that cyclic amegakaryocytic thrombocytopenia may be due to an antibody that selectively blocks the action of GM-CSF on megakaryocyte progenitor cells. Case Report A 21-year-old woman first experienced…

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
JournalNew England Journal of Medicine
Volume321
Issue number2
DOIs
StatePublished - Jul 13 1989

ASJC Scopus subject areas

  • Medicine(all)

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