Acquired cystic disease-associated renal tumors: An immunohistochemical and fluorescence in situ hybridization study

Paolo Cossu-Rocca, John N. Eble, Shaobo Zhang, Guido Martignoni, Matteo Brunelli, Liang Cheng

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70 Scopus citations


End-stage renal disease is associated with an increased incidence of renal cell neoplasms. Among these, recent studies have identified tumors with unusual histological patterns that do not fit into the categories recognized in the current classification system. These tumors often occur in kidneys with acquired cystic disease and are composed mainly of large eosinophilic cells arranged in solid, cribriform, acinar, or papillary patterns. They also contain deposits of calcium oxalate crystals. We investigated three eosinophilic epithelial tumors arising in kidneys with acquired cystic disease from three patients. Each of the tumors was composed of large eosinophilic cells arranged in solid, acinar, or tubulocystic architecture. Deposits of calcium oxalate crystals were present in each tumor. Hale's colloidal stain showed a positive cytoplasmic reaction in one of the neoplasms. Immunohistochemistry displayed positive results for CD10 (3/3), AE1/AE3 (3/3), alpha-methylacyl-CoA racemase (2/3), CAM5.2 (2/3), and vimentin (1/3). Reactions for epithelial membrane antigen, cytokeratin 7, and high molecular weight cytokeratin (34βE12) were negative. Fluorescence in situ hybridization analysis showed no losses or gains of chromosomes 1, 2, 6, 10, or 17 in one tumor. There were gains of chromosomes 1, 2, and 6 in two tumors. One of these tumors also showed gains of chromosome 10. Eosinophilic renal cell tumors associated with acquired cystic disease have immunophenotypes and genetic profiles distinct from the renal cell neoplasms recognized in the current classification of renal cell neoplasia, and should be considered as a distinct clinicopathologic entity in the spectrum of renal cell neoplasia.

Original languageEnglish (US)
Pages (from-to)780-787
Number of pages8
JournalModern Pathology
Issue number6
StatePublished - Jun 1 2006



  • Acquired cystic disease of kidney
  • Calcium oxalate
  • Cytogenetics
  • End-stage renal disease
  • Fluorescence in situ hybridization (FISH)
  • Kidney tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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