Acquired pellicle as a modulator for dental erosion

Dusa Vukosavljevic, William Custodio, Marilia A R Buzalaf, Anderson Hara, Walter L. Siqueira

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Dental erosion is a multifactorial condition that can result in the loss of tooth structure and function, potentially increasing tooth sensitivity. The exposure of enamel to acids from non-bacterial sources is responsible for the progression of erosion. These erosive challenges are counteracted by the anti-erosive properties of the acquired pellicle (AP), an integument formed in vivo as a result of selective adsorption of salivary proteins on the tooth surface, containing also lipids and glycoproteins. This review provides an in-depth discussion regarding how the physical structure of the AP, along with its composition, contributes to AP anti-erosive properties. The physical properties that contribute to AP protective nature include pellicle thickness, maturation time, and site of development. The pellicle contains salivary proteins embedded within its structure that demonstrate anti-erosive properties; however, rather than individual proteins, protein-protein interactions play a fundamental role in the protective nature of the AP. In addition, dietary and synthetic proteins can modify the pellicle, enhancing its protective efficiency against dental erosion. The salivary composition of the AP and its corresponding protein-profile may be employed as a diagnostic tool, since it likely contains salivary biomarkers for oral diseases that initiate at the enamel surface, including dental erosion. Finally, by modifying the composition and structure of the AP, this protein integument has the potential to be used as a target-specific treatment option for oral diseases related to tooth demineralization.

Original languageEnglish (US)
Pages (from-to)631-638
Number of pages8
JournalArchives of Oral Biology
Volume59
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Tooth Erosion
Mouth Diseases
Salivary Proteins and Peptides
Dental Enamel
Proteins
Tooth Demineralization
Dental Pellicle
Dentin Sensitivity
Tooth Loss
Dietary Proteins
Adsorption
Glycoproteins
Tooth
Biomarkers
Lipids
Acids

Keywords

  • Acquired pellicle
  • Dental erosion
  • Proteins
  • Saliva

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Cell Biology
  • Dentistry(all)
  • Medicine(all)

Cite this

Vukosavljevic, D., Custodio, W., Buzalaf, M. A. R., Hara, A., & Siqueira, W. L. (2014). Acquired pellicle as a modulator for dental erosion. Archives of Oral Biology, 59(6), 631-638. https://doi.org/10.1016/j.archoralbio.2014.02.002

Acquired pellicle as a modulator for dental erosion. / Vukosavljevic, Dusa; Custodio, William; Buzalaf, Marilia A R; Hara, Anderson; Siqueira, Walter L.

In: Archives of Oral Biology, Vol. 59, No. 6, 2014, p. 631-638.

Research output: Contribution to journalArticle

Vukosavljevic, D, Custodio, W, Buzalaf, MAR, Hara, A & Siqueira, WL 2014, 'Acquired pellicle as a modulator for dental erosion', Archives of Oral Biology, vol. 59, no. 6, pp. 631-638. https://doi.org/10.1016/j.archoralbio.2014.02.002
Vukosavljevic, Dusa ; Custodio, William ; Buzalaf, Marilia A R ; Hara, Anderson ; Siqueira, Walter L. / Acquired pellicle as a modulator for dental erosion. In: Archives of Oral Biology. 2014 ; Vol. 59, No. 6. pp. 631-638.
@article{8eee393122364a7989a65e4912377438,
title = "Acquired pellicle as a modulator for dental erosion",
abstract = "Dental erosion is a multifactorial condition that can result in the loss of tooth structure and function, potentially increasing tooth sensitivity. The exposure of enamel to acids from non-bacterial sources is responsible for the progression of erosion. These erosive challenges are counteracted by the anti-erosive properties of the acquired pellicle (AP), an integument formed in vivo as a result of selective adsorption of salivary proteins on the tooth surface, containing also lipids and glycoproteins. This review provides an in-depth discussion regarding how the physical structure of the AP, along with its composition, contributes to AP anti-erosive properties. The physical properties that contribute to AP protective nature include pellicle thickness, maturation time, and site of development. The pellicle contains salivary proteins embedded within its structure that demonstrate anti-erosive properties; however, rather than individual proteins, protein-protein interactions play a fundamental role in the protective nature of the AP. In addition, dietary and synthetic proteins can modify the pellicle, enhancing its protective efficiency against dental erosion. The salivary composition of the AP and its corresponding protein-profile may be employed as a diagnostic tool, since it likely contains salivary biomarkers for oral diseases that initiate at the enamel surface, including dental erosion. Finally, by modifying the composition and structure of the AP, this protein integument has the potential to be used as a target-specific treatment option for oral diseases related to tooth demineralization.",
keywords = "Acquired pellicle, Dental erosion, Proteins, Saliva",
author = "Dusa Vukosavljevic and William Custodio and Buzalaf, {Marilia A R} and Anderson Hara and Siqueira, {Walter L.}",
year = "2014",
doi = "10.1016/j.archoralbio.2014.02.002",
language = "English (US)",
volume = "59",
pages = "631--638",
journal = "Archives of Oral Biology",
issn = "0003-9969",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Acquired pellicle as a modulator for dental erosion

AU - Vukosavljevic, Dusa

AU - Custodio, William

AU - Buzalaf, Marilia A R

AU - Hara, Anderson

AU - Siqueira, Walter L.

PY - 2014

Y1 - 2014

N2 - Dental erosion is a multifactorial condition that can result in the loss of tooth structure and function, potentially increasing tooth sensitivity. The exposure of enamel to acids from non-bacterial sources is responsible for the progression of erosion. These erosive challenges are counteracted by the anti-erosive properties of the acquired pellicle (AP), an integument formed in vivo as a result of selective adsorption of salivary proteins on the tooth surface, containing also lipids and glycoproteins. This review provides an in-depth discussion regarding how the physical structure of the AP, along with its composition, contributes to AP anti-erosive properties. The physical properties that contribute to AP protective nature include pellicle thickness, maturation time, and site of development. The pellicle contains salivary proteins embedded within its structure that demonstrate anti-erosive properties; however, rather than individual proteins, protein-protein interactions play a fundamental role in the protective nature of the AP. In addition, dietary and synthetic proteins can modify the pellicle, enhancing its protective efficiency against dental erosion. The salivary composition of the AP and its corresponding protein-profile may be employed as a diagnostic tool, since it likely contains salivary biomarkers for oral diseases that initiate at the enamel surface, including dental erosion. Finally, by modifying the composition and structure of the AP, this protein integument has the potential to be used as a target-specific treatment option for oral diseases related to tooth demineralization.

AB - Dental erosion is a multifactorial condition that can result in the loss of tooth structure and function, potentially increasing tooth sensitivity. The exposure of enamel to acids from non-bacterial sources is responsible for the progression of erosion. These erosive challenges are counteracted by the anti-erosive properties of the acquired pellicle (AP), an integument formed in vivo as a result of selective adsorption of salivary proteins on the tooth surface, containing also lipids and glycoproteins. This review provides an in-depth discussion regarding how the physical structure of the AP, along with its composition, contributes to AP anti-erosive properties. The physical properties that contribute to AP protective nature include pellicle thickness, maturation time, and site of development. The pellicle contains salivary proteins embedded within its structure that demonstrate anti-erosive properties; however, rather than individual proteins, protein-protein interactions play a fundamental role in the protective nature of the AP. In addition, dietary and synthetic proteins can modify the pellicle, enhancing its protective efficiency against dental erosion. The salivary composition of the AP and its corresponding protein-profile may be employed as a diagnostic tool, since it likely contains salivary biomarkers for oral diseases that initiate at the enamel surface, including dental erosion. Finally, by modifying the composition and structure of the AP, this protein integument has the potential to be used as a target-specific treatment option for oral diseases related to tooth demineralization.

KW - Acquired pellicle

KW - Dental erosion

KW - Proteins

KW - Saliva

UR - http://www.scopus.com/inward/record.url?scp=84898607668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898607668&partnerID=8YFLogxK

U2 - 10.1016/j.archoralbio.2014.02.002

DO - 10.1016/j.archoralbio.2014.02.002

M3 - Article

VL - 59

SP - 631

EP - 638

JO - Archives of Oral Biology

JF - Archives of Oral Biology

SN - 0003-9969

IS - 6

ER -