Acquired thrombophilic syndromes

Daniela Matei, Benjamin Brenner, Victor J. Marder

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

As the biochemical mechanisms of hypercoagulable states are revealed, the syndromes of venous thromboembolism have been increasingly associated with specific aberrations. Most of these changes involve an increase in procoagulant potential, for example, by activation of the coagulation cascade, or by a defect or decrease in natural inhibitors of clotting. Similar abnormalities of the fibrinolytic pathways may contribute, as can loss of inhibitory mechanisms of endothelial cells, as well as changes in vascular anatomy and rheologic patterns of blood flow. All of these factors can directly influence thrombus formation and/or the physiologic response to the thrombus.

Original languageEnglish (US)
Pages (from-to)31-48
Number of pages18
JournalBlood Reviews
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Hematology
  • Oncology

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