Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat

Michael R. Due, Jonghyuck Park, Lingxing Zheng, Michael Walls, Yohance M. Allette, Fletcher White, Riyi Shi

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Growing evidence suggests that oxidative stress, as associated with spinal cord injury (SCI), may play a critical role in both neuroinflammation and neuropathic pain conditions. The production of the endogenous aldehyde acrolein, following lipid peroxidation during the inflammatory response, may contribute to peripheral sensitization and hyperreflexia following SCI via the TRPA1-dependent mechanism. Here, we report that there are enhanced levels of acrolein and increased neuronal sensitivity to the aldehyde for at least 14 days after SCI. Concurrent with injury-induced increases in acrolein concentration is an increased expression of TRPA1 in the lumbar (L3-L6) sensory ganglia. As proof of the potential pronociceptive role for acrolein, intrathecal injections of acrolein revealed enhanced sensitivity to both tactile and thermal stimuli for up to 10 days, supporting the compound's pro-nociceptive functionality. Treatment of SCI animals with the acrolein scavenger hydralazine produced moderate improvement in tactile responses as well as robust changes in thermal sensitivity for up to 49 days. Taken together, these data suggest that acrolein directly modulates SCI-associated pain behavior, making it a novel therapeutic target for preclinical and clinical SCI as an analgesic.

Original languageEnglish
Pages (from-to)776-786
Number of pages11
JournalJournal of Neurochemistry
Volume128
Issue number5
DOIs
StatePublished - Mar 2014

Fingerprint

Acrolein
Spinal Cord Injuries
Rats
Hypersensitivity
Touch
Aldehydes
Hot Temperature
Sensory Ganglia
Spinal Injections
Hydralazine
Abnormal Reflexes
Oxidative stress
Neuralgia
Lipid Peroxidation
Analgesics
Animals
Oxidative Stress
Lipids
Pain
Wounds and Injuries

Keywords

  • aldehyde
  • hydralazine
  • hyperreflexia
  • lipid peroxidation
  • proalgesic
  • TRPA1

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat. / Due, Michael R.; Park, Jonghyuck; Zheng, Lingxing; Walls, Michael; Allette, Yohance M.; White, Fletcher; Shi, Riyi.

In: Journal of Neurochemistry, Vol. 128, No. 5, 03.2014, p. 776-786.

Research output: Contribution to journalArticle

Due, Michael R. ; Park, Jonghyuck ; Zheng, Lingxing ; Walls, Michael ; Allette, Yohance M. ; White, Fletcher ; Shi, Riyi. / Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat. In: Journal of Neurochemistry. 2014 ; Vol. 128, No. 5. pp. 776-786.
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