ACTIVE cognitive training and rates of incident dementia

Frederick Unverzagt, Lin T. Guey, Richard N. Jones, Michael Marsiske, Jonathan W. King, Virginia G. Wadley, Michael Crowe, George W. Rebok, Sharon L. Tennstedt

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Systematic cognitive training produces long-term improvement in cognitive function and less difficulty in performing activities of daily living. We examined whether cognitive training was associated with reduced rate of incident dementia. Participants were from the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study (n = 2,802). Incident dementia was defined using a combination of interview-and performance-based methods. Survival analysis was used to determine if ACTIVE treatment affected the rate of incident dementia during 5 years of follow-up. A total of 189 participants met criteria for incident dementia. Baseline factors predictive of incident dementia were older age, male gender, African American race, fewer years of education, relationship other than married, no alcohol use, worse MMSE, worse SF-36 physical functioning, higher depressive symptomatology, diabetes, and stroke (all p <.05). A multivariable model with significant predictors of incident dementia and training group revealed that cognitive training was not associated with a lower rate of incident dementia. Cognitive training did not affect rates of incident dementia after 5 years of follow-up. Longer follow-up or enhanced training may be needed to fully explore the preventive capacity of cognitive training in forestalling onset of dementia.

Original languageEnglish
Pages (from-to)669-677
Number of pages9
JournalJournal of the International Neuropsychological Society
Volume18
Issue number4
DOIs
StatePublished - Jul 2012

Fingerprint

dementia
Dementia
incident
Survival Analysis
Activities of Daily Living
stroke
African Americans
Cognition
chronic illness
Stroke
alcohol
Alcohols
Interviews
Education
gender
interview
performance

Keywords

  • Aging
  • Cognition
  • Cognitive training
  • Dementia
  • Intervention
  • Prevention

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Clinical Psychology
  • Neuroscience(all)
  • Language and Linguistics
  • Linguistics and Language

Cite this

Unverzagt, F., Guey, L. T., Jones, R. N., Marsiske, M., King, J. W., Wadley, V. G., ... Tennstedt, S. L. (2012). ACTIVE cognitive training and rates of incident dementia. Journal of the International Neuropsychological Society, 18(4), 669-677. https://doi.org/10.1017/S1355617711001470

ACTIVE cognitive training and rates of incident dementia. / Unverzagt, Frederick; Guey, Lin T.; Jones, Richard N.; Marsiske, Michael; King, Jonathan W.; Wadley, Virginia G.; Crowe, Michael; Rebok, George W.; Tennstedt, Sharon L.

In: Journal of the International Neuropsychological Society, Vol. 18, No. 4, 07.2012, p. 669-677.

Research output: Contribution to journalArticle

Unverzagt, F, Guey, LT, Jones, RN, Marsiske, M, King, JW, Wadley, VG, Crowe, M, Rebok, GW & Tennstedt, SL 2012, 'ACTIVE cognitive training and rates of incident dementia', Journal of the International Neuropsychological Society, vol. 18, no. 4, pp. 669-677. https://doi.org/10.1017/S1355617711001470
Unverzagt, Frederick ; Guey, Lin T. ; Jones, Richard N. ; Marsiske, Michael ; King, Jonathan W. ; Wadley, Virginia G. ; Crowe, Michael ; Rebok, George W. ; Tennstedt, Sharon L. / ACTIVE cognitive training and rates of incident dementia. In: Journal of the International Neuropsychological Society. 2012 ; Vol. 18, No. 4. pp. 669-677.
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