ACTIVE cognitive training and rates of incident dementia

Frederick W. Unverzagt, Lin T. Guey, Richard N. Jones, Michael Marsiske, Jonathan W. King, Virginia G. Wadley, Michael Crowe, George W. Rebok, Sharon L. Tennstedt

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Systematic cognitive training produces long-term improvement in cognitive function and less difficulty in performing activities of daily living. We examined whether cognitive training was associated with reduced rate of incident dementia. Participants were from the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study (n = 2,802). Incident dementia was defined using a combination of interview-and performance-based methods. Survival analysis was used to determine if ACTIVE treatment affected the rate of incident dementia during 5 years of follow-up. A total of 189 participants met criteria for incident dementia. Baseline factors predictive of incident dementia were older age, male gender, African American race, fewer years of education, relationship other than married, no alcohol use, worse MMSE, worse SF-36 physical functioning, higher depressive symptomatology, diabetes, and stroke (all p <.05). A multivariable model with significant predictors of incident dementia and training group revealed that cognitive training was not associated with a lower rate of incident dementia. Cognitive training did not affect rates of incident dementia after 5 years of follow-up. Longer follow-up or enhanced training may be needed to fully explore the preventive capacity of cognitive training in forestalling onset of dementia.

Original languageEnglish (US)
Pages (from-to)669-677
Number of pages9
JournalJournal of the International Neuropsychological Society
Volume18
Issue number4
DOIs
StatePublished - Jul 2012

Keywords

  • Aging
  • Cognition
  • Cognitive training
  • Dementia
  • Intervention
  • Prevention

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Clinical Psychology
  • Neuroscience(all)
  • Language and Linguistics
  • Linguistics and Language

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    Unverzagt, F. W., Guey, L. T., Jones, R. N., Marsiske, M., King, J. W., Wadley, V. G., Crowe, M., Rebok, G. W., & Tennstedt, S. L. (2012). ACTIVE cognitive training and rates of incident dementia. Journal of the International Neuropsychological Society, 18(4), 669-677. https://doi.org/10.1017/S1355617711001470