Abstract
Background: Functional imaging studies indicate that imbalances in cortico-limbic activity and connectivity may underlie the pathophysiology of MDD. In this study, using functional Magnetic Resonance Imaging (fMRI), we investigated differences in cortico-limbic activity and connectivity between depressed patients and healthy controls. Methods: Fifteen unmedicated unipolar depressed patients and 15 matched healthy subjects underwent fMRI during which they first completed a conventional block-design activation experiment in which they were exposed to negative and neutral pictures. Next, low frequency blood oxygenation dependent (BOLD) related fluctuations (LFBF) data were acquired at rest and during steady-state exposure to neutral, positive and negative pictures. LFBF correlations were calculated between anterior cingulate cortex (ACC) and limbic regions - amygdala (AMYG), pallidostriatum (PST) and medial thalamus (MTHAL) and used as a measure of cortico-limbic connectivity. Results: Depressed patients had increased activation of cortical and limbic regions. At rest and during exposure to neutral, positive, and negative pictures cortico-limbic LFBF correlations were decreased in depressed patients compared to healthy subjects. Conclusions: The finding of increased activation of limbic regions and decreased LFBF correlations between ACC and limbic regions is consistent with the hypothesis that decreased cortical regulation of limbic activation in response to negative stimuli may be present in depression.
| Original language | English |
|---|---|
| Pages (from-to) | 1079-1088 |
| Number of pages | 10 |
| Journal | Biological Psychiatry |
| Volume | 57 |
| Issue number | 10 |
| DOIs | |
| State | Published - May 15 2005 |
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Keywords
- Connectivity
- Cortico-limbic
- Depression
- Emotional valence
- fMRI
- Low frequency BOLD fluctuations
- Mood circuit
ASJC Scopus subject areas
- Biological Psychiatry
Cite this
Activity and connectivity of brain mood regulating circuit in depression : A functional magnetic resonance study. / Anand, Amit; Li, Yu; Wang, Yang; Wu, Jingwei; Gao, Sujuan; Bukhari, Lubna; Mathews, Vincent; Kalnin, Andrew; Lowe, Mark J.
In: Biological Psychiatry, Vol. 57, No. 10, 15.05.2005, p. 1079-1088.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Activity and connectivity of brain mood regulating circuit in depression
T2 - A functional magnetic resonance study
AU - Anand, Amit
AU - Li, Yu
AU - Wang, Yang
AU - Wu, Jingwei
AU - Gao, Sujuan
AU - Bukhari, Lubna
AU - Mathews, Vincent
AU - Kalnin, Andrew
AU - Lowe, Mark J.
PY - 2005/5/15
Y1 - 2005/5/15
N2 - Background: Functional imaging studies indicate that imbalances in cortico-limbic activity and connectivity may underlie the pathophysiology of MDD. In this study, using functional Magnetic Resonance Imaging (fMRI), we investigated differences in cortico-limbic activity and connectivity between depressed patients and healthy controls. Methods: Fifteen unmedicated unipolar depressed patients and 15 matched healthy subjects underwent fMRI during which they first completed a conventional block-design activation experiment in which they were exposed to negative and neutral pictures. Next, low frequency blood oxygenation dependent (BOLD) related fluctuations (LFBF) data were acquired at rest and during steady-state exposure to neutral, positive and negative pictures. LFBF correlations were calculated between anterior cingulate cortex (ACC) and limbic regions - amygdala (AMYG), pallidostriatum (PST) and medial thalamus (MTHAL) and used as a measure of cortico-limbic connectivity. Results: Depressed patients had increased activation of cortical and limbic regions. At rest and during exposure to neutral, positive, and negative pictures cortico-limbic LFBF correlations were decreased in depressed patients compared to healthy subjects. Conclusions: The finding of increased activation of limbic regions and decreased LFBF correlations between ACC and limbic regions is consistent with the hypothesis that decreased cortical regulation of limbic activation in response to negative stimuli may be present in depression.
AB - Background: Functional imaging studies indicate that imbalances in cortico-limbic activity and connectivity may underlie the pathophysiology of MDD. In this study, using functional Magnetic Resonance Imaging (fMRI), we investigated differences in cortico-limbic activity and connectivity between depressed patients and healthy controls. Methods: Fifteen unmedicated unipolar depressed patients and 15 matched healthy subjects underwent fMRI during which they first completed a conventional block-design activation experiment in which they were exposed to negative and neutral pictures. Next, low frequency blood oxygenation dependent (BOLD) related fluctuations (LFBF) data were acquired at rest and during steady-state exposure to neutral, positive and negative pictures. LFBF correlations were calculated between anterior cingulate cortex (ACC) and limbic regions - amygdala (AMYG), pallidostriatum (PST) and medial thalamus (MTHAL) and used as a measure of cortico-limbic connectivity. Results: Depressed patients had increased activation of cortical and limbic regions. At rest and during exposure to neutral, positive, and negative pictures cortico-limbic LFBF correlations were decreased in depressed patients compared to healthy subjects. Conclusions: The finding of increased activation of limbic regions and decreased LFBF correlations between ACC and limbic regions is consistent with the hypothesis that decreased cortical regulation of limbic activation in response to negative stimuli may be present in depression.
KW - Connectivity
KW - Cortico-limbic
KW - Depression
KW - Emotional valence
KW - fMRI
KW - Low frequency BOLD fluctuations
KW - Mood circuit
UR - http://www.scopus.com/inward/record.url?scp=18144363240&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18144363240&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2005.02.021
DO - 10.1016/j.biopsych.2005.02.021
M3 - Article
C2 - 15866546
AN - SCOPUS:18144363240
VL - 57
SP - 1079
EP - 1088
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 10
ER -