Activity and connectivity of brain mood regulating circuit in depression

A functional magnetic resonance study

Amit Anand, Yu Li, Yang Wang, Jingwei Wu, Sujuan Gao, Lubna Bukhari, Vincent Mathews, Andrew Kalnin, Mark J. Lowe

Research output: Contribution to journalArticle

521 Citations (Scopus)

Abstract

Background: Functional imaging studies indicate that imbalances in cortico-limbic activity and connectivity may underlie the pathophysiology of MDD. In this study, using functional Magnetic Resonance Imaging (fMRI), we investigated differences in cortico-limbic activity and connectivity between depressed patients and healthy controls. Methods: Fifteen unmedicated unipolar depressed patients and 15 matched healthy subjects underwent fMRI during which they first completed a conventional block-design activation experiment in which they were exposed to negative and neutral pictures. Next, low frequency blood oxygenation dependent (BOLD) related fluctuations (LFBF) data were acquired at rest and during steady-state exposure to neutral, positive and negative pictures. LFBF correlations were calculated between anterior cingulate cortex (ACC) and limbic regions - amygdala (AMYG), pallidostriatum (PST) and medial thalamus (MTHAL) and used as a measure of cortico-limbic connectivity. Results: Depressed patients had increased activation of cortical and limbic regions. At rest and during exposure to neutral, positive, and negative pictures cortico-limbic LFBF correlations were decreased in depressed patients compared to healthy subjects. Conclusions: The finding of increased activation of limbic regions and decreased LFBF correlations between ACC and limbic regions is consistent with the hypothesis that decreased cortical regulation of limbic activation in response to negative stimuli may be present in depression.

Original languageEnglish
Pages (from-to)1079-1088
Number of pages10
JournalBiological Psychiatry
Volume57
Issue number10
DOIs
StatePublished - May 15 2005

Fingerprint

Magnetic Resonance Spectroscopy
Depression
Gyrus Cinguli
Brain
Healthy Volunteers
Magnetic Resonance Imaging
Amygdala
Thalamus

Keywords

  • Connectivity
  • Cortico-limbic
  • Depression
  • Emotional valence
  • fMRI
  • Low frequency BOLD fluctuations
  • Mood circuit

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Activity and connectivity of brain mood regulating circuit in depression : A functional magnetic resonance study. / Anand, Amit; Li, Yu; Wang, Yang; Wu, Jingwei; Gao, Sujuan; Bukhari, Lubna; Mathews, Vincent; Kalnin, Andrew; Lowe, Mark J.

In: Biological Psychiatry, Vol. 57, No. 10, 15.05.2005, p. 1079-1088.

Research output: Contribution to journalArticle

Anand, Amit ; Li, Yu ; Wang, Yang ; Wu, Jingwei ; Gao, Sujuan ; Bukhari, Lubna ; Mathews, Vincent ; Kalnin, Andrew ; Lowe, Mark J. / Activity and connectivity of brain mood regulating circuit in depression : A functional magnetic resonance study. In: Biological Psychiatry. 2005 ; Vol. 57, No. 10. pp. 1079-1088.
@article{87bcad295c2a4f63bba7966e104e9bc7,
title = "Activity and connectivity of brain mood regulating circuit in depression: A functional magnetic resonance study",
abstract = "Background: Functional imaging studies indicate that imbalances in cortico-limbic activity and connectivity may underlie the pathophysiology of MDD. In this study, using functional Magnetic Resonance Imaging (fMRI), we investigated differences in cortico-limbic activity and connectivity between depressed patients and healthy controls. Methods: Fifteen unmedicated unipolar depressed patients and 15 matched healthy subjects underwent fMRI during which they first completed a conventional block-design activation experiment in which they were exposed to negative and neutral pictures. Next, low frequency blood oxygenation dependent (BOLD) related fluctuations (LFBF) data were acquired at rest and during steady-state exposure to neutral, positive and negative pictures. LFBF correlations were calculated between anterior cingulate cortex (ACC) and limbic regions - amygdala (AMYG), pallidostriatum (PST) and medial thalamus (MTHAL) and used as a measure of cortico-limbic connectivity. Results: Depressed patients had increased activation of cortical and limbic regions. At rest and during exposure to neutral, positive, and negative pictures cortico-limbic LFBF correlations were decreased in depressed patients compared to healthy subjects. Conclusions: The finding of increased activation of limbic regions and decreased LFBF correlations between ACC and limbic regions is consistent with the hypothesis that decreased cortical regulation of limbic activation in response to negative stimuli may be present in depression.",
keywords = "Connectivity, Cortico-limbic, Depression, Emotional valence, fMRI, Low frequency BOLD fluctuations, Mood circuit",
author = "Amit Anand and Yu Li and Yang Wang and Jingwei Wu and Sujuan Gao and Lubna Bukhari and Vincent Mathews and Andrew Kalnin and Lowe, {Mark J.}",
year = "2005",
month = "5",
day = "15",
doi = "10.1016/j.biopsych.2005.02.021",
language = "English",
volume = "57",
pages = "1079--1088",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "10",

}

TY - JOUR

T1 - Activity and connectivity of brain mood regulating circuit in depression

T2 - A functional magnetic resonance study

AU - Anand, Amit

AU - Li, Yu

AU - Wang, Yang

AU - Wu, Jingwei

AU - Gao, Sujuan

AU - Bukhari, Lubna

AU - Mathews, Vincent

AU - Kalnin, Andrew

AU - Lowe, Mark J.

PY - 2005/5/15

Y1 - 2005/5/15

N2 - Background: Functional imaging studies indicate that imbalances in cortico-limbic activity and connectivity may underlie the pathophysiology of MDD. In this study, using functional Magnetic Resonance Imaging (fMRI), we investigated differences in cortico-limbic activity and connectivity between depressed patients and healthy controls. Methods: Fifteen unmedicated unipolar depressed patients and 15 matched healthy subjects underwent fMRI during which they first completed a conventional block-design activation experiment in which they were exposed to negative and neutral pictures. Next, low frequency blood oxygenation dependent (BOLD) related fluctuations (LFBF) data were acquired at rest and during steady-state exposure to neutral, positive and negative pictures. LFBF correlations were calculated between anterior cingulate cortex (ACC) and limbic regions - amygdala (AMYG), pallidostriatum (PST) and medial thalamus (MTHAL) and used as a measure of cortico-limbic connectivity. Results: Depressed patients had increased activation of cortical and limbic regions. At rest and during exposure to neutral, positive, and negative pictures cortico-limbic LFBF correlations were decreased in depressed patients compared to healthy subjects. Conclusions: The finding of increased activation of limbic regions and decreased LFBF correlations between ACC and limbic regions is consistent with the hypothesis that decreased cortical regulation of limbic activation in response to negative stimuli may be present in depression.

AB - Background: Functional imaging studies indicate that imbalances in cortico-limbic activity and connectivity may underlie the pathophysiology of MDD. In this study, using functional Magnetic Resonance Imaging (fMRI), we investigated differences in cortico-limbic activity and connectivity between depressed patients and healthy controls. Methods: Fifteen unmedicated unipolar depressed patients and 15 matched healthy subjects underwent fMRI during which they first completed a conventional block-design activation experiment in which they were exposed to negative and neutral pictures. Next, low frequency blood oxygenation dependent (BOLD) related fluctuations (LFBF) data were acquired at rest and during steady-state exposure to neutral, positive and negative pictures. LFBF correlations were calculated between anterior cingulate cortex (ACC) and limbic regions - amygdala (AMYG), pallidostriatum (PST) and medial thalamus (MTHAL) and used as a measure of cortico-limbic connectivity. Results: Depressed patients had increased activation of cortical and limbic regions. At rest and during exposure to neutral, positive, and negative pictures cortico-limbic LFBF correlations were decreased in depressed patients compared to healthy subjects. Conclusions: The finding of increased activation of limbic regions and decreased LFBF correlations between ACC and limbic regions is consistent with the hypothesis that decreased cortical regulation of limbic activation in response to negative stimuli may be present in depression.

KW - Connectivity

KW - Cortico-limbic

KW - Depression

KW - Emotional valence

KW - fMRI

KW - Low frequency BOLD fluctuations

KW - Mood circuit

UR - http://www.scopus.com/inward/record.url?scp=18144363240&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18144363240&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2005.02.021

DO - 10.1016/j.biopsych.2005.02.021

M3 - Article

VL - 57

SP - 1079

EP - 1088

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 10

ER -