Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT

Anastasia Papadopoulou, Ulrike Gerdemann, Usha L. Katari, Ifigenia Tzannou, Hao Liu, Caridad Martinez, Kathryn Leung, George Carrum, Adrian P. Gee, Juan F. Vera, Robert A. Krance, Malcolm K. Brenner, Cliona M. Rooney, Helen E. Heslop, Ann M. Leen

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

It remains difficult to treat the multiplicity of distinct viral infections that afflict immunocompromised patients. Adoptive transfer of virus-specific T cells (VSTs) can be safe and effective, but such cells have been complex to prepare and limited in antiviral range. We now demonstrate the feasibility and clinical utility of rapidly generated single-culture VSTs that recognize 12 immunogenic antigens from five viruses (Epstein-Barr virus, adenovirus, cytomegalovirus, BK virus, and human herpesvirus 6) that frequently cause disease in immunocompromised patients. When administered to 11 recipients of allogeneic transplants, 8 of whom had up to four active infections with the targeted viruses, these VSTs proved safe in all subjects and produced an overall 94% virological and clinical response rate that was sustained long-term.

Original languageEnglish (US)
Article number242ra83
JournalScience Translational Medicine
Volume6
Issue number242
DOIs
StatePublished - Jun 25 2014
Externally publishedYes

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Human Herpesvirus 6
Human Herpesvirus 4
Immunocompromised Host
Viruses
T-Lymphocytes
Infection
BK Virus
Adoptive Transfer
Virus Diseases
Cytomegalovirus
Adenoviridae
Antiviral Agents
Therapeutics
Antigens

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT. / Papadopoulou, Anastasia; Gerdemann, Ulrike; Katari, Usha L.; Tzannou, Ifigenia; Liu, Hao; Martinez, Caridad; Leung, Kathryn; Carrum, George; Gee, Adrian P.; Vera, Juan F.; Krance, Robert A.; Brenner, Malcolm K.; Rooney, Cliona M.; Heslop, Helen E.; Leen, Ann M.

In: Science Translational Medicine, Vol. 6, No. 242, 242ra83, 25.06.2014.

Research output: Contribution to journalArticle

Papadopoulou, A, Gerdemann, U, Katari, UL, Tzannou, I, Liu, H, Martinez, C, Leung, K, Carrum, G, Gee, AP, Vera, JF, Krance, RA, Brenner, MK, Rooney, CM, Heslop, HE & Leen, AM 2014, 'Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT', Science Translational Medicine, vol. 6, no. 242, 242ra83. https://doi.org/10.1126/scitranslmed.3008825
Papadopoulou, Anastasia ; Gerdemann, Ulrike ; Katari, Usha L. ; Tzannou, Ifigenia ; Liu, Hao ; Martinez, Caridad ; Leung, Kathryn ; Carrum, George ; Gee, Adrian P. ; Vera, Juan F. ; Krance, Robert A. ; Brenner, Malcolm K. ; Rooney, Cliona M. ; Heslop, Helen E. ; Leen, Ann M. / Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT. In: Science Translational Medicine. 2014 ; Vol. 6, No. 242.
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