Activity of chemokines in prostate and renal tumors and their potential role as future therapeutic targets

Alessia Cimadamore, Marina Scarpelli, Francesco Piva, Francesco Massari, Silvia Gasparrini, Andrea Doria, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Chemokines are a class of low-molecular-weight proteins that induce chemotaxis and are implicated in the modulation of angiogenesis. The imbalance among angiogenic and antiangiogenic chemokines can promote the development of several conditions, including chronic inflammation, dysplastic transformation and cancer. In this review, we describe the activity and clinical significance of chemokines in prostate and renal tumors and provide an update on ongoing studies in this setting.

Original languageEnglish (US)
Pages (from-to)1105-1114
Number of pages10
JournalFuture Oncology
Volume13
Issue number12
DOIs
StatePublished - May 1 2017

Keywords

  • angiogenesis
  • chemokines
  • prostate cancer
  • renal cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Cimadamore, A., Scarpelli, M., Piva, F., Massari, F., Gasparrini, S., Doria, A., Cheng, L., Lopez-Beltran, A., & Montironi, R. (2017). Activity of chemokines in prostate and renal tumors and their potential role as future therapeutic targets. Future Oncology, 13(12), 1105-1114. https://doi.org/10.2217/fon-2016-0481