Activity of hypothalamic monoaminergic systems during immobilization after chronic stress in rats

Dmitry Zaretsky, E. I. Kalenikova, L. M. Livanova, A. I. Kuzmin, M. V. Zaretskaya, M. G. Airapetyants, O. S. Medvedev, E. I. Chazov

Research output: Contribution to journalArticle

Abstract

The influence of chronic stress (footshock combuned with randomozed light flashes) on acute stress-induced (immobilization) release of noradrenaline, dopamine and serotonin in rat lateral hypothalamus was assessed by microdialysis. The chronic stress resulted in an increase and prolongation of the acute stress-induced release of noradrenaline but not of dopamine and serotonin. The increased rate of accumulation of dioxyphenylacetic acid and unchanged accumulation of homovanillic acid (dopamine metabolites) and dopamine during and after the acute stress in chronically stressed animals reflect a rise of synthetic activity of catecholaminergic systems in response to acute stress and reuptake increase. Marked stress-induced increase in hydroxyindoleacetic acid in chronically stressed rats without any changes in the ST dynamics may be regarded in a similar way. A significant increase in potassium-stimulated release of all the studied monoamines was found while their basal level remained unchanged. The conclusion was made that the hyperergic release of neurotransmitters may be the basis of an inadequate response of animals to acute stress, i.e., one of the neurotic symptoms.

Original languageEnglish
Pages (from-to)319-320
Number of pages2
JournalZhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
Volume49
Issue number2
StatePublished - 1999
Externally publishedYes

Fingerprint

Immobilization
Dopamine
Serotonin
Norepinephrine
Lateral Hypothalamic Area
Homovanillic Acid
Hydroxyindoleacetic Acid
Microdialysis
Neurotransmitter Agents
Potassium
Light
Acids

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Zaretsky, D., Kalenikova, E. I., Livanova, L. M., Kuzmin, A. I., Zaretskaya, M. V., Airapetyants, M. G., ... Chazov, E. I. (1999). Activity of hypothalamic monoaminergic systems during immobilization after chronic stress in rats. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, 49(2), 319-320.

Activity of hypothalamic monoaminergic systems during immobilization after chronic stress in rats. / Zaretsky, Dmitry; Kalenikova, E. I.; Livanova, L. M.; Kuzmin, A. I.; Zaretskaya, M. V.; Airapetyants, M. G.; Medvedev, O. S.; Chazov, E. I.

In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, Vol. 49, No. 2, 1999, p. 319-320.

Research output: Contribution to journalArticle

Zaretsky, D, Kalenikova, EI, Livanova, LM, Kuzmin, AI, Zaretskaya, MV, Airapetyants, MG, Medvedev, OS & Chazov, EI 1999, 'Activity of hypothalamic monoaminergic systems during immobilization after chronic stress in rats', Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, vol. 49, no. 2, pp. 319-320.
Zaretsky, Dmitry ; Kalenikova, E. I. ; Livanova, L. M. ; Kuzmin, A. I. ; Zaretskaya, M. V. ; Airapetyants, M. G. ; Medvedev, O. S. ; Chazov, E. I. / Activity of hypothalamic monoaminergic systems during immobilization after chronic stress in rats. In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 1999 ; Vol. 49, No. 2. pp. 319-320.
@article{8f7240d57d1748c39dad11557ed01d05,
title = "Activity of hypothalamic monoaminergic systems during immobilization after chronic stress in rats",
abstract = "The influence of chronic stress (footshock combuned with randomozed light flashes) on acute stress-induced (immobilization) release of noradrenaline, dopamine and serotonin in rat lateral hypothalamus was assessed by microdialysis. The chronic stress resulted in an increase and prolongation of the acute stress-induced release of noradrenaline but not of dopamine and serotonin. The increased rate of accumulation of dioxyphenylacetic acid and unchanged accumulation of homovanillic acid (dopamine metabolites) and dopamine during and after the acute stress in chronically stressed animals reflect a rise of synthetic activity of catecholaminergic systems in response to acute stress and reuptake increase. Marked stress-induced increase in hydroxyindoleacetic acid in chronically stressed rats without any changes in the ST dynamics may be regarded in a similar way. A significant increase in potassium-stimulated release of all the studied monoamines was found while their basal level remained unchanged. The conclusion was made that the hyperergic release of neurotransmitters may be the basis of an inadequate response of animals to acute stress, i.e., one of the neurotic symptoms.",
author = "Dmitry Zaretsky and Kalenikova, {E. I.} and Livanova, {L. M.} and Kuzmin, {A. I.} and Zaretskaya, {M. V.} and Airapetyants, {M. G.} and Medvedev, {O. S.} and Chazov, {E. I.}",
year = "1999",
language = "English",
volume = "49",
pages = "319--320",
journal = "Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova",
issn = "0044-4677",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "2",

}

TY - JOUR

T1 - Activity of hypothalamic monoaminergic systems during immobilization after chronic stress in rats

AU - Zaretsky, Dmitry

AU - Kalenikova, E. I.

AU - Livanova, L. M.

AU - Kuzmin, A. I.

AU - Zaretskaya, M. V.

AU - Airapetyants, M. G.

AU - Medvedev, O. S.

AU - Chazov, E. I.

PY - 1999

Y1 - 1999

N2 - The influence of chronic stress (footshock combuned with randomozed light flashes) on acute stress-induced (immobilization) release of noradrenaline, dopamine and serotonin in rat lateral hypothalamus was assessed by microdialysis. The chronic stress resulted in an increase and prolongation of the acute stress-induced release of noradrenaline but not of dopamine and serotonin. The increased rate of accumulation of dioxyphenylacetic acid and unchanged accumulation of homovanillic acid (dopamine metabolites) and dopamine during and after the acute stress in chronically stressed animals reflect a rise of synthetic activity of catecholaminergic systems in response to acute stress and reuptake increase. Marked stress-induced increase in hydroxyindoleacetic acid in chronically stressed rats without any changes in the ST dynamics may be regarded in a similar way. A significant increase in potassium-stimulated release of all the studied monoamines was found while their basal level remained unchanged. The conclusion was made that the hyperergic release of neurotransmitters may be the basis of an inadequate response of animals to acute stress, i.e., one of the neurotic symptoms.

AB - The influence of chronic stress (footshock combuned with randomozed light flashes) on acute stress-induced (immobilization) release of noradrenaline, dopamine and serotonin in rat lateral hypothalamus was assessed by microdialysis. The chronic stress resulted in an increase and prolongation of the acute stress-induced release of noradrenaline but not of dopamine and serotonin. The increased rate of accumulation of dioxyphenylacetic acid and unchanged accumulation of homovanillic acid (dopamine metabolites) and dopamine during and after the acute stress in chronically stressed animals reflect a rise of synthetic activity of catecholaminergic systems in response to acute stress and reuptake increase. Marked stress-induced increase in hydroxyindoleacetic acid in chronically stressed rats without any changes in the ST dynamics may be regarded in a similar way. A significant increase in potassium-stimulated release of all the studied monoamines was found while their basal level remained unchanged. The conclusion was made that the hyperergic release of neurotransmitters may be the basis of an inadequate response of animals to acute stress, i.e., one of the neurotic symptoms.

UR - http://www.scopus.com/inward/record.url?scp=0346969698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346969698&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0346969698

VL - 49

SP - 319

EP - 320

JO - Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova

JF - Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova

SN - 0044-4677

IS - 2

ER -