Activity of hypothalamic monoaminergic systems during immobilization after chronic stress in rats

D. V. Zaretsky, E. I. Kalenikova, L. M. Livanova, A. I. Kuzmin, M. V. Zaretskaya, M. G. Airapetyants, O. S. Medvedev, E. I. Chazov

Research output: Contribution to journalArticle

Abstract

The influence of chronic stress (footshock combuned with randomozed light flashes) on acute stress-induced (immobilization) release of noradrenaline, dopamine and serotonin in rat lateral hypothalamus was assessed by microdialysis. The chronic stress resulted in an increase and prolongation of the acute stress-induced release of noradrenaline but not of dopamine and serotonin. The increased rate of accumulation of dioxyphenylacetic acid and unchanged accumulation of homovanillic acid (dopamine metabolites) and dopamine during and after the acute stress in chronically stressed animals reflect a rise of synthetic activity of catecholaminergic systems in response to acute stress and reuptake increase. Marked stress-induced increase in hydroxyindoleacetic acid in chronically stressed rats without any changes in the ST dynamics may be regarded in a similar way. A significant increase in potassium-stimulated release of all the studied monoamines was found while their basal level remained unchanged. The conclusion was made that the hyperergic release of neurotransmitters may be the basis of an inadequate response of animals to acute stress, i.e., one of the neurotic symptoms.

Original languageEnglish (US)
Pages (from-to)319-320
Number of pages2
JournalZhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
Volume49
Issue number2
StatePublished - Dec 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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    Zaretsky, D. V., Kalenikova, E. I., Livanova, L. M., Kuzmin, A. I., Zaretskaya, M. V., Airapetyants, M. G., Medvedev, O. S., & Chazov, E. I. (1999). Activity of hypothalamic monoaminergic systems during immobilization after chronic stress in rats. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, 49(2), 319-320.