Activity of inosine analogs against Pneumocystis carinii in culture

M. S. Bartlett, J. J. Marr, S. F. Queener, R. S. Klein, J. W. Smith

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Three analogs of inosine, formycin B, allopurinol ribonucleoside, and 9-deazainosine, were tested for their ability to suppress proliferation of Pneumocystis carinii in culture with WI-38 cells. The organism was inhibited by 9-deazainosine at 10 μg/ml, and there was some inhibition at 1 μg/ml. Formycin B was effective only at 40 μg/ml. Allopurinol ribonucleoside had little effect.

Original languageEnglish (US)
Pages (from-to)181-183
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume30
Issue number1
DOIs
StatePublished - Jan 1 1986

Fingerprint

Pneumocystis carinii
Inosine
allopurinol riboside
9-deazainosine
formycin B

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Activity of inosine analogs against Pneumocystis carinii in culture. / Bartlett, M. S.; Marr, J. J.; Queener, S. F.; Klein, R. S.; Smith, J. W.

In: Antimicrobial Agents and Chemotherapy, Vol. 30, No. 1, 01.01.1986, p. 181-183.

Research output: Contribution to journalArticle

Bartlett, M. S. ; Marr, J. J. ; Queener, S. F. ; Klein, R. S. ; Smith, J. W. / Activity of inosine analogs against Pneumocystis carinii in culture. In: Antimicrobial Agents and Chemotherapy. 1986 ; Vol. 30, No. 1. pp. 181-183.
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