Activity of inosine analogs against Pneumocystis carinii in culture

M. S. Bartlett, J. J. Marr, S. F. Queener, R. S. Klein, J. W. Smith

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Three analogs of inosine, formycin B, allopurinol ribonucleoside, and 9-deazainosine, were tested for their ability to suppress proliferation of Pneumocystis carinii in culture with WI-38 cells. The organism was inhibited by 9-deazainosine at 10 μg/ml, and there was some inhibition at 1 μg/ml. Formycin B was effective only at 40 μg/ml. Allopurinol ribonucleoside had little effect.

Original languageEnglish (US)
Pages (from-to)181-183
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume30
Issue number1
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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