Activity of topoisomerase inhibitors against Pneumocystis carinii in vitro and in an inoculated mouse model

J. A. Fishman, S. F. Queener, R. S. Roth, M. S. Bartlett

Research output: Contribution to journalComment/debate

16 Scopus citations

Abstract

Five topoisomerase II inhibitors (amsacrine [m-AMSA], two epipodophyllotoxins, and two quinolones) and the alkaloid camptothecin (a topoisomerase I inhibitor) were evaluated to assess their activities against Pneumocystis carinii. In vitro, both etoposide (VP-16) and teniposide (VM- 26) at 1 μg/ml suppressed P. carinii growth. Amsacrine was toxic to P. carinii and to the feeder cells in vitro. Camptothecin suppressed the growth of P. carinii in vitro only at 100 μg/ml. Studies in immunosuppressed mice demonstrated the efficacy of teniposide against P. carinii pneumonia, but successful administration of teniposide was schedule dependent with significant toxicity at therapeutic dosages.

Original languageEnglish (US)
Pages (from-to)1543-1546
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume37
Issue number7
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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