Acupuncture for substance use disorders: A systematic review and meta-analysis

Sean Grant, Ryan Kandrack, Aneesa Motala, Roberta Shanman, Marika Booth, Jeremy Miles, Melony Sorbero, Susanne Hempel

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Background: This systematic review aims to estimate the effects of acupuncture for adults with substance use disorders (SUDs). Methods: We searched 7 electronic databases and bibliographies of previous studies to identify eligible randomized trials. Two independent reviewers screened citations, extracted data, and assessed risks of bias. We performed random effects meta-analyses. We assessed quality of evidence using the GRADE approach. Results: We included 41 studies with 5,227 participants. No significant differences were observed between acupuncture and comparators (passive controls, sham acupuncture, treatment as usual, and active interventions) at post-intervention for relapse (SMD -0.12; 95%CI -0.46 to 0.22; 10 RCTs), frequency of substance use (SMD -0.27; -2.67 to 2.13; 2 RCTs), quantity of substance use (SMD 0.01; -0.40 to 0.43; 3 RCTs), and treatment dropout (OR 0.82; 0.63 to 1.09; 22 RCTs). We identified a significant difference in favor of acupuncture versus comparators for withdrawal/craving at post-intervention (SMD -0.57, -0.93 to -0.20; 20 RCTs), but we identified evidence of publication bias. We also identified a significant difference in favor of acupuncture versus comparators for anxiety at post-intervention (SMD -0.74, -1.15 to -0.33; 6 RCTs). Results for withdrawal/craving and anxiety symptoms were not significant at longer follow-up. Safety data (12 RCTs) suggests little risk of serious adverse events, though participants may experience slight bleeding or pain at needle insertion sites. Conclusions: Available evidence suggests no consistent differences between acupuncture and comparators for substance use. Results in favor of acupuncture for withdrawal/craving and anxiety symptoms are limited by low quality bodies of evidence.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalDrug and Alcohol Dependence
Volume163
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Keywords

  • Accupuncture
  • Meta-analysis
  • Substance use disorder
  • Systematic review

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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  • Cite this

    Grant, S., Kandrack, R., Motala, A., Shanman, R., Booth, M., Miles, J., Sorbero, M., & Hempel, S. (2016). Acupuncture for substance use disorders: A systematic review and meta-analysis. Drug and Alcohol Dependence, 163, 1-15. https://doi.org/10.1016/j.drugalcdep.2016.02.034