Acupuncture treatment for ischaemic stroke in young adults: Protocol for a randomised, sham-controlled clinical trial

Lifang Chen, Jianqiao Fang, Xiaoming Jin, Crystal Lynn Keeler, Hong Gao, Zhen Fang, Qin Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: Stroke in young adults is not uncommon. Although the overall incidence of stroke has been recently declining, the incidence of stroke in young adults is increasing. Traditional vascular risk factors are the main cause of young ischaemic stroke. Acupuncture has been shown to benefit stroke rehabilitation and ameliorate the risk factors for stroke. The aims of this study were to determine whether acupuncture treatment will be effective in improving the activities of daily living (ADL), motor function and quality of life (QOL) in patients of young ischaemic stroke, and in preventing stroke recurrence by controlling blood pressure, lipids and body weight. Methods and analysis: In this randomised, sham-controlled, participant-blinded and assessor-blinded clinical trial, 120 patients between 18 and 45 years of age with a recent (within 1 month) ischaemic stroke will be randomised for an 8-week acupuncture or sham acupuncture treatment. The primary outcome will be the Barthel Index for ADL. The secondary outcomes will include the Fugl-Meyer Assessment for motor function; the World Health Organization Quality of Life BREF (WHOQOL-BREF) for QOL; and risk factors that are measured by ambulatory blood pressure, the fasting serum lipid, body mass index and waist circumference. Incidence of adverse events and longterm mortality and recurrence rate during a 10-year and 30-year follow-up will also be investigated. Ethics and dissemination: Ethics approval was obtained from the Ethics Committee of The Third Affiliated Hospital of Zhejiang Chinese Medical University. Protocol V.3 was approved in June 2013. The results will be disseminated in a peer-reviewed journal and presented at international congresses. The results will also be disseminated to patients by telephone during follow-up calls enquiring on the patient's post-study health status.

Original languageEnglish (US)
Article numbere010073
JournalBMJ Open
Volume6
Issue number1
DOIs
StatePublished - 2016

Fingerprint

Acupuncture Therapy
Young Adult
Randomized Controlled Trials
Stroke
Quality of Life
Acupuncture
Activities of Daily Living
Ethics
Incidence
Blood Pressure
Recurrence
Ethics Committees
Waist Circumference
Telephone
Health Status
Fasting
Body Mass Index
Placebos
Body Weight
Clinical Trials

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Acupuncture treatment for ischaemic stroke in young adults : Protocol for a randomised, sham-controlled clinical trial. / Chen, Lifang; Fang, Jianqiao; Jin, Xiaoming; Keeler, Crystal Lynn; Gao, Hong; Fang, Zhen; Chen, Qin.

In: BMJ Open, Vol. 6, No. 1, e010073, 2016.

Research output: Contribution to journalArticle

Chen, Lifang ; Fang, Jianqiao ; Jin, Xiaoming ; Keeler, Crystal Lynn ; Gao, Hong ; Fang, Zhen ; Chen, Qin. / Acupuncture treatment for ischaemic stroke in young adults : Protocol for a randomised, sham-controlled clinical trial. In: BMJ Open. 2016 ; Vol. 6, No. 1.
@article{493687a944014d49b5a590842b6efce6,
title = "Acupuncture treatment for ischaemic stroke in young adults: Protocol for a randomised, sham-controlled clinical trial",
abstract = "Introduction: Stroke in young adults is not uncommon. Although the overall incidence of stroke has been recently declining, the incidence of stroke in young adults is increasing. Traditional vascular risk factors are the main cause of young ischaemic stroke. Acupuncture has been shown to benefit stroke rehabilitation and ameliorate the risk factors for stroke. The aims of this study were to determine whether acupuncture treatment will be effective in improving the activities of daily living (ADL), motor function and quality of life (QOL) in patients of young ischaemic stroke, and in preventing stroke recurrence by controlling blood pressure, lipids and body weight. Methods and analysis: In this randomised, sham-controlled, participant-blinded and assessor-blinded clinical trial, 120 patients between 18 and 45 years of age with a recent (within 1 month) ischaemic stroke will be randomised for an 8-week acupuncture or sham acupuncture treatment. The primary outcome will be the Barthel Index for ADL. The secondary outcomes will include the Fugl-Meyer Assessment for motor function; the World Health Organization Quality of Life BREF (WHOQOL-BREF) for QOL; and risk factors that are measured by ambulatory blood pressure, the fasting serum lipid, body mass index and waist circumference. Incidence of adverse events and longterm mortality and recurrence rate during a 10-year and 30-year follow-up will also be investigated. Ethics and dissemination: Ethics approval was obtained from the Ethics Committee of The Third Affiliated Hospital of Zhejiang Chinese Medical University. Protocol V.3 was approved in June 2013. The results will be disseminated in a peer-reviewed journal and presented at international congresses. The results will also be disseminated to patients by telephone during follow-up calls enquiring on the patient's post-study health status.",
author = "Lifang Chen and Jianqiao Fang and Xiaoming Jin and Keeler, {Crystal Lynn} and Hong Gao and Zhen Fang and Qin Chen",
year = "2016",
doi = "10.1136/bmjopen-2015-010073",
language = "English (US)",
volume = "6",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "1",

}

TY - JOUR

T1 - Acupuncture treatment for ischaemic stroke in young adults

T2 - Protocol for a randomised, sham-controlled clinical trial

AU - Chen, Lifang

AU - Fang, Jianqiao

AU - Jin, Xiaoming

AU - Keeler, Crystal Lynn

AU - Gao, Hong

AU - Fang, Zhen

AU - Chen, Qin

PY - 2016

Y1 - 2016

N2 - Introduction: Stroke in young adults is not uncommon. Although the overall incidence of stroke has been recently declining, the incidence of stroke in young adults is increasing. Traditional vascular risk factors are the main cause of young ischaemic stroke. Acupuncture has been shown to benefit stroke rehabilitation and ameliorate the risk factors for stroke. The aims of this study were to determine whether acupuncture treatment will be effective in improving the activities of daily living (ADL), motor function and quality of life (QOL) in patients of young ischaemic stroke, and in preventing stroke recurrence by controlling blood pressure, lipids and body weight. Methods and analysis: In this randomised, sham-controlled, participant-blinded and assessor-blinded clinical trial, 120 patients between 18 and 45 years of age with a recent (within 1 month) ischaemic stroke will be randomised for an 8-week acupuncture or sham acupuncture treatment. The primary outcome will be the Barthel Index for ADL. The secondary outcomes will include the Fugl-Meyer Assessment for motor function; the World Health Organization Quality of Life BREF (WHOQOL-BREF) for QOL; and risk factors that are measured by ambulatory blood pressure, the fasting serum lipid, body mass index and waist circumference. Incidence of adverse events and longterm mortality and recurrence rate during a 10-year and 30-year follow-up will also be investigated. Ethics and dissemination: Ethics approval was obtained from the Ethics Committee of The Third Affiliated Hospital of Zhejiang Chinese Medical University. Protocol V.3 was approved in June 2013. The results will be disseminated in a peer-reviewed journal and presented at international congresses. The results will also be disseminated to patients by telephone during follow-up calls enquiring on the patient's post-study health status.

AB - Introduction: Stroke in young adults is not uncommon. Although the overall incidence of stroke has been recently declining, the incidence of stroke in young adults is increasing. Traditional vascular risk factors are the main cause of young ischaemic stroke. Acupuncture has been shown to benefit stroke rehabilitation and ameliorate the risk factors for stroke. The aims of this study were to determine whether acupuncture treatment will be effective in improving the activities of daily living (ADL), motor function and quality of life (QOL) in patients of young ischaemic stroke, and in preventing stroke recurrence by controlling blood pressure, lipids and body weight. Methods and analysis: In this randomised, sham-controlled, participant-blinded and assessor-blinded clinical trial, 120 patients between 18 and 45 years of age with a recent (within 1 month) ischaemic stroke will be randomised for an 8-week acupuncture or sham acupuncture treatment. The primary outcome will be the Barthel Index for ADL. The secondary outcomes will include the Fugl-Meyer Assessment for motor function; the World Health Organization Quality of Life BREF (WHOQOL-BREF) for QOL; and risk factors that are measured by ambulatory blood pressure, the fasting serum lipid, body mass index and waist circumference. Incidence of adverse events and longterm mortality and recurrence rate during a 10-year and 30-year follow-up will also be investigated. Ethics and dissemination: Ethics approval was obtained from the Ethics Committee of The Third Affiliated Hospital of Zhejiang Chinese Medical University. Protocol V.3 was approved in June 2013. The results will be disseminated in a peer-reviewed journal and presented at international congresses. The results will also be disseminated to patients by telephone during follow-up calls enquiring on the patient's post-study health status.

UR - http://www.scopus.com/inward/record.url?scp=84960467837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960467837&partnerID=8YFLogxK

U2 - 10.1136/bmjopen-2015-010073

DO - 10.1136/bmjopen-2015-010073

M3 - Article

C2 - 26739742

AN - SCOPUS:84960467837

VL - 6

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 1

M1 - e010073

ER -