Acute 5-HT reuptake blockade potentiates human amygdala reactivity

Kristin L. Bigos, Bruce G. Pollock, Howard J. Aizenstein, Patrick M. Fisher, Robert Bies, Ahmad R. Hariri

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Variability in serotonin (5-HT) function is associated with individual differences in normal mood and temperament, as well as psychiatric illnesses, all of which are influenced by amygdala function. This study evaluated the acute effects of 5-HT reuptake blockade on amygdala function using pharmacological functional MRI. Eight healthy men completed a double-blind balanced crossover study with the selective 5-HT reuptake inhibitor, citalopram (20 mg infused over 30 min), and normal saline. Amygdala reactivity in response to novel facial expressions was assessed on three successive scans, once before drug/placebo infusion, once early in the infusion, and once at the end of infusion. Acute citalopram administration resulted in concentration-dependent increases in human amygdala reactivity to salient stimuli. The current pattern of 5-HT-mediated amygdala reactivity may represent an important pathway through which SSRIs achieve an antidepressant effect. Intriguingly, our data may also reveal a mechanism contributing to clinical observations of extreme agitation, restlessness, and suicidal ideation in some individuals during acute SSRI treatment. Developing a comprehensive model of how 5-HT modulates human amygdala reactivity supporting behavioral and physiological arousal will be instrumental for our understanding of basic neurobehavioral processes, their dysfunction in psychiatric illnesses, and their contribution to mechanism of treatment response.

Original languageEnglish (US)
Pages (from-to)3221-3225
Number of pages5
JournalNeuropsychopharmacology
Volume33
Issue number13
DOIs
StatePublished - Dec 2008
Externally publishedYes

Fingerprint

Amygdala
Serotonin
Citalopram
Psychiatry
Psychomotor Agitation
Suicidal Ideation
Facial Expression
Temperament
Arousal
Individuality
Cross-Over Studies
Antidepressive Agents
Placebos
Magnetic Resonance Imaging
Pharmacology
Therapeutics
Pharmaceutical Preparations

Keywords

  • Amygdala
  • Citalopram
  • Functional MRI
  • Healthy subjects
  • Serotonin
  • SSRI

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Bigos, K. L., Pollock, B. G., Aizenstein, H. J., Fisher, P. M., Bies, R., & Hariri, A. R. (2008). Acute 5-HT reuptake blockade potentiates human amygdala reactivity. Neuropsychopharmacology, 33(13), 3221-3225. https://doi.org/10.1038/npp.2008.52

Acute 5-HT reuptake blockade potentiates human amygdala reactivity. / Bigos, Kristin L.; Pollock, Bruce G.; Aizenstein, Howard J.; Fisher, Patrick M.; Bies, Robert; Hariri, Ahmad R.

In: Neuropsychopharmacology, Vol. 33, No. 13, 12.2008, p. 3221-3225.

Research output: Contribution to journalArticle

Bigos, KL, Pollock, BG, Aizenstein, HJ, Fisher, PM, Bies, R & Hariri, AR 2008, 'Acute 5-HT reuptake blockade potentiates human amygdala reactivity', Neuropsychopharmacology, vol. 33, no. 13, pp. 3221-3225. https://doi.org/10.1038/npp.2008.52
Bigos KL, Pollock BG, Aizenstein HJ, Fisher PM, Bies R, Hariri AR. Acute 5-HT reuptake blockade potentiates human amygdala reactivity. Neuropsychopharmacology. 2008 Dec;33(13):3221-3225. https://doi.org/10.1038/npp.2008.52
Bigos, Kristin L. ; Pollock, Bruce G. ; Aizenstein, Howard J. ; Fisher, Patrick M. ; Bies, Robert ; Hariri, Ahmad R. / Acute 5-HT reuptake blockade potentiates human amygdala reactivity. In: Neuropsychopharmacology. 2008 ; Vol. 33, No. 13. pp. 3221-3225.
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