Acute and subchronic effects of methylenedioxymethamphetamine [(±)MDMA] on locomotion and serotonin syndrome behavior in the rat

Linda J. Spanos, Bryan K. Yamamoto

Research output: Contribution to journalArticle

154 Scopus citations

Abstract

Specific behaviors comprising the serotonin syndrome (low body posture, forepaw treading, headweaving) and the automatic signs of piloerection and salivation were determined and analyzed with locomotor activity in response to MDMA at three doses (2.5, 5.0, and 7.5 mg/kg). All behaviors were dose-responsive. Serotonin syndrome behaviors increased in both intensity and duration of response with increasing doses. In contrast, locomotion varied only in intensity. Subchronic injections, in the same group of animals, permitted an analysis of acute vs. subchronic effects on these same behaviors. Both the serotonin syndrome and locomotor behaviors were augmented on subsequent testing, indicating that, (±)MDMA, like amphetamine, is capable of producing behavioral sensitization.

Original languageEnglish (US)
Pages (from-to)835-840
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume32
Issue number4
DOIs
StatePublished - Apr 1989
Externally publishedYes

Keywords

  • 3,4-Methylenedioxymethamphetamine (MDMA)
  • Hyperlocomotion
  • Serotonin syndrome

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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