Abstract
Acute hypercapnia was studied to assess its potential as a noninvasive and simple test for evoking neuroendocrine, cardiovascular and psychological responses to stress in man. A single breath of four concentrations of carbon dioxide (CO2), 5%, 25%, 35% and 50%, was administered to nine healthy volunteers in a randomized, single-blind fashion. Although no adverse effects occurred, most subjects were unable to take a full inspired vital capacity breath of 50% CO2. In response to the remaining exposures, subjective and somatic symptoms of anxiety increased in a dose-dependent manner. Unlike 5% and 25% CO 2, 35% CO2 stimulated significant adrenocorticotropic hormone and noradrenaline release at 2 min and cortisol and prolactin release at 15 min following inhalation. This same dose also provoked a significant bradycardia that was followed by an acute pressor response. No significant habituation of psychological, hypothalamic-pituitary-adrenal (HPA) or cardiovascular responses following 35% CO2 was seen when this dose was repeated after 1 week. A single breath of 35% CO2 safely and reliably produced sympathetic and HPA axis activation and should prove a useful addition to currently available laboratory tests of the human stress response.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 256-264 |
| Number of pages | 9 |
| Journal | Journal of Neuroendocrinology |
| Volume | 16 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2004 |
| Externally published | Yes |
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Keywords
- Carbon dioxide
- Catecholamines
- Cortisol
- HPA axis
- Stress
ASJC Scopus subject areas
- Endocrinology
- Neuroscience(all)
Cite this
Acute carbon dioxide exposure in healthy adults : Evaluation of a novel means of investigating the stress response. / Kaye, Joey; Buchanan, F.; Kendrick, A.; Johnson, Philip; Lowry, C.; Bailey, J.; Nutt, D.; Lightman, S.
In: Journal of Neuroendocrinology, Vol. 16, No. 3, 03.2004, p. 256-264.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute carbon dioxide exposure in healthy adults
T2 - Evaluation of a novel means of investigating the stress response
AU - Kaye, Joey
AU - Buchanan, F.
AU - Kendrick, A.
AU - Johnson, Philip
AU - Lowry, C.
AU - Bailey, J.
AU - Nutt, D.
AU - Lightman, S.
PY - 2004/3
Y1 - 2004/3
N2 - Acute hypercapnia was studied to assess its potential as a noninvasive and simple test for evoking neuroendocrine, cardiovascular and psychological responses to stress in man. A single breath of four concentrations of carbon dioxide (CO2), 5%, 25%, 35% and 50%, was administered to nine healthy volunteers in a randomized, single-blind fashion. Although no adverse effects occurred, most subjects were unable to take a full inspired vital capacity breath of 50% CO2. In response to the remaining exposures, subjective and somatic symptoms of anxiety increased in a dose-dependent manner. Unlike 5% and 25% CO 2, 35% CO2 stimulated significant adrenocorticotropic hormone and noradrenaline release at 2 min and cortisol and prolactin release at 15 min following inhalation. This same dose also provoked a significant bradycardia that was followed by an acute pressor response. No significant habituation of psychological, hypothalamic-pituitary-adrenal (HPA) or cardiovascular responses following 35% CO2 was seen when this dose was repeated after 1 week. A single breath of 35% CO2 safely and reliably produced sympathetic and HPA axis activation and should prove a useful addition to currently available laboratory tests of the human stress response.
AB - Acute hypercapnia was studied to assess its potential as a noninvasive and simple test for evoking neuroendocrine, cardiovascular and psychological responses to stress in man. A single breath of four concentrations of carbon dioxide (CO2), 5%, 25%, 35% and 50%, was administered to nine healthy volunteers in a randomized, single-blind fashion. Although no adverse effects occurred, most subjects were unable to take a full inspired vital capacity breath of 50% CO2. In response to the remaining exposures, subjective and somatic symptoms of anxiety increased in a dose-dependent manner. Unlike 5% and 25% CO 2, 35% CO2 stimulated significant adrenocorticotropic hormone and noradrenaline release at 2 min and cortisol and prolactin release at 15 min following inhalation. This same dose also provoked a significant bradycardia that was followed by an acute pressor response. No significant habituation of psychological, hypothalamic-pituitary-adrenal (HPA) or cardiovascular responses following 35% CO2 was seen when this dose was repeated after 1 week. A single breath of 35% CO2 safely and reliably produced sympathetic and HPA axis activation and should prove a useful addition to currently available laboratory tests of the human stress response.
KW - Carbon dioxide
KW - Catecholamines
KW - Cortisol
KW - HPA axis
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=1842485025&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1842485025&partnerID=8YFLogxK
U2 - 10.1111/j.0953-8194.2004.01158.x
DO - 10.1111/j.0953-8194.2004.01158.x
M3 - Article
C2 - 15049856
AN - SCOPUS:1842485025
VL - 16
SP - 256
EP - 264
JO - Journal of Neuroendocrinology
JF - Journal of Neuroendocrinology
SN - 0953-8194
IS - 3
ER -