Acute effect of topical β-adrenergic antagonists on normal perimacular hemodynamics

Alon Harris, John A. Shoemaker, Jennifer Burgoyne, Monika Weinland, Louis Cantor

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: β-adrenergic antagonists are the most commonly prescribed antiglaucoma medications. The nonselective β blocker timolol has been shown to either increase or to not affect retinal blood flow, despite the suggestion that the drug may cause vasoconstriction due to its blockade of β-2 receptors. Other β blockers with unique pharmacologies may produce different effects on blood flow. We studied the effects of betaxolol (β-1 selective antagonist), carteolol (nonselective β-antagonist with intrinsic sympathomimetic activity), and levobunolol (nonselective β antagonist with intrinsic sympathomimetic activity), and levobunolol (nonselective β antagonist with active polar metabolite) on perimacular hemodynamics. Method: On four separate occasions separated by at least 10 days, 16 normal subjects performed measurements of heart rate, blood pressure, IOP, and blue field entoptic simulation assessment of leukocyte velocity and density before and 2 h after instillation of one of the three drugs or an artificial tears placebo. Results: IOP was significantly reduced by all three drugs as compared to placebo (p < 0.05, Bonferroni-corrected two-tailed paired t-test). No significant differences were found in heart rate, blood pressure, and perimacular leukocyte velocity or density in any of the treatment conditions as compared to placebo. Conclusions: Betaxolol, carteolol, and levobunolol do not appear to significantly alter perimacular hemodynamics 2 h after administration. The absence of any acute change in hemodynamics despite the drop in IOP suggests normal autoregulation maintained constant blood flow.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalJournal of Glaucoma
Volume4
Issue number1
StatePublished - 1995

Fingerprint

Levobunolol
Adrenergic Antagonists
Carteolol
Betaxolol
Sympathomimetics
Hemodynamics
Placebos
Leukocytes
Heart Rate
Pharmaceutical Preparations
Blood Pressure
Timolol
Vasoconstriction
Homeostasis
Pharmacology
Therapeutics

Keywords

  • Betaxol
  • Carteolol
  • Levobunolol
  • Retinal blood flow

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Acute effect of topical β-adrenergic antagonists on normal perimacular hemodynamics. / Harris, Alon; Shoemaker, John A.; Burgoyne, Jennifer; Weinland, Monika; Cantor, Louis.

In: Journal of Glaucoma, Vol. 4, No. 1, 1995, p. 36-40.

Research output: Contribution to journalArticle

Harris, Alon ; Shoemaker, John A. ; Burgoyne, Jennifer ; Weinland, Monika ; Cantor, Louis. / Acute effect of topical β-adrenergic antagonists on normal perimacular hemodynamics. In: Journal of Glaucoma. 1995 ; Vol. 4, No. 1. pp. 36-40.
@article{5bbcb0f5765e49068013a2b5cbc80539,
title = "Acute effect of topical β-adrenergic antagonists on normal perimacular hemodynamics",
abstract = "Purpose: β-adrenergic antagonists are the most commonly prescribed antiglaucoma medications. The nonselective β blocker timolol has been shown to either increase or to not affect retinal blood flow, despite the suggestion that the drug may cause vasoconstriction due to its blockade of β-2 receptors. Other β blockers with unique pharmacologies may produce different effects on blood flow. We studied the effects of betaxolol (β-1 selective antagonist), carteolol (nonselective β-antagonist with intrinsic sympathomimetic activity), and levobunolol (nonselective β antagonist with intrinsic sympathomimetic activity), and levobunolol (nonselective β antagonist with active polar metabolite) on perimacular hemodynamics. Method: On four separate occasions separated by at least 10 days, 16 normal subjects performed measurements of heart rate, blood pressure, IOP, and blue field entoptic simulation assessment of leukocyte velocity and density before and 2 h after instillation of one of the three drugs or an artificial tears placebo. Results: IOP was significantly reduced by all three drugs as compared to placebo (p < 0.05, Bonferroni-corrected two-tailed paired t-test). No significant differences were found in heart rate, blood pressure, and perimacular leukocyte velocity or density in any of the treatment conditions as compared to placebo. Conclusions: Betaxolol, carteolol, and levobunolol do not appear to significantly alter perimacular hemodynamics 2 h after administration. The absence of any acute change in hemodynamics despite the drop in IOP suggests normal autoregulation maintained constant blood flow.",
keywords = "Betaxol, Carteolol, Levobunolol, Retinal blood flow",
author = "Alon Harris and Shoemaker, {John A.} and Jennifer Burgoyne and Monika Weinland and Louis Cantor",
year = "1995",
language = "English",
volume = "4",
pages = "36--40",
journal = "Journal of Glaucoma",
issn = "1057-0829",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Acute effect of topical β-adrenergic antagonists on normal perimacular hemodynamics

AU - Harris, Alon

AU - Shoemaker, John A.

AU - Burgoyne, Jennifer

AU - Weinland, Monika

AU - Cantor, Louis

PY - 1995

Y1 - 1995

N2 - Purpose: β-adrenergic antagonists are the most commonly prescribed antiglaucoma medications. The nonselective β blocker timolol has been shown to either increase or to not affect retinal blood flow, despite the suggestion that the drug may cause vasoconstriction due to its blockade of β-2 receptors. Other β blockers with unique pharmacologies may produce different effects on blood flow. We studied the effects of betaxolol (β-1 selective antagonist), carteolol (nonselective β-antagonist with intrinsic sympathomimetic activity), and levobunolol (nonselective β antagonist with intrinsic sympathomimetic activity), and levobunolol (nonselective β antagonist with active polar metabolite) on perimacular hemodynamics. Method: On four separate occasions separated by at least 10 days, 16 normal subjects performed measurements of heart rate, blood pressure, IOP, and blue field entoptic simulation assessment of leukocyte velocity and density before and 2 h after instillation of one of the three drugs or an artificial tears placebo. Results: IOP was significantly reduced by all three drugs as compared to placebo (p < 0.05, Bonferroni-corrected two-tailed paired t-test). No significant differences were found in heart rate, blood pressure, and perimacular leukocyte velocity or density in any of the treatment conditions as compared to placebo. Conclusions: Betaxolol, carteolol, and levobunolol do not appear to significantly alter perimacular hemodynamics 2 h after administration. The absence of any acute change in hemodynamics despite the drop in IOP suggests normal autoregulation maintained constant blood flow.

AB - Purpose: β-adrenergic antagonists are the most commonly prescribed antiglaucoma medications. The nonselective β blocker timolol has been shown to either increase or to not affect retinal blood flow, despite the suggestion that the drug may cause vasoconstriction due to its blockade of β-2 receptors. Other β blockers with unique pharmacologies may produce different effects on blood flow. We studied the effects of betaxolol (β-1 selective antagonist), carteolol (nonselective β-antagonist with intrinsic sympathomimetic activity), and levobunolol (nonselective β antagonist with intrinsic sympathomimetic activity), and levobunolol (nonselective β antagonist with active polar metabolite) on perimacular hemodynamics. Method: On four separate occasions separated by at least 10 days, 16 normal subjects performed measurements of heart rate, blood pressure, IOP, and blue field entoptic simulation assessment of leukocyte velocity and density before and 2 h after instillation of one of the three drugs or an artificial tears placebo. Results: IOP was significantly reduced by all three drugs as compared to placebo (p < 0.05, Bonferroni-corrected two-tailed paired t-test). No significant differences were found in heart rate, blood pressure, and perimacular leukocyte velocity or density in any of the treatment conditions as compared to placebo. Conclusions: Betaxolol, carteolol, and levobunolol do not appear to significantly alter perimacular hemodynamics 2 h after administration. The absence of any acute change in hemodynamics despite the drop in IOP suggests normal autoregulation maintained constant blood flow.

KW - Betaxol

KW - Carteolol

KW - Levobunolol

KW - Retinal blood flow

UR - http://www.scopus.com/inward/record.url?scp=0028955767&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028955767&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0028955767

VL - 4

SP - 36

EP - 40

JO - Journal of Glaucoma

JF - Journal of Glaucoma

SN - 1057-0829

IS - 1

ER -