Acute graft-versus-host disease of the lung after liver transplantation

Kenneth S. Knox, Mehrdad Behnia, Lisa R. Smith, Gail Vance, Michael Busk, Oscar Cummings, Paul Y. Kwo, David S. Wilkes

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We describe the first case of a man who developed acute graft-versus-host disease (GVHD), isolated to the lung, after an orthotopic liver transplant from a female donor. Our patient experienced dyspnea, worsening hypoxemia, and a progressive obstructive ventilatory defect 12 days after liver transplantation. Open-lung biopsy revealed grade 2 lymphocytic bronchiolitis, the pathologic and immunologic correlate of acute pulmonary GVHD. Fluorescent in situ hybridization confirmed donor cells at sites of peribronchiolar inflammation. High-dose corticosteroids were given with a return to baseline pulmonary function. The current case should alert clinicians to investigate pulmonary GVHD as a potential cause of postoperative dyspnea in liver transplant recipient.

Original languageEnglish
Pages (from-to)968-971
Number of pages4
JournalLiver Transplantation
Volume8
Issue number10
DOIs
StatePublished - Oct 1 2002

Fingerprint

Graft vs Host Disease
Liver Transplantation
Lung
Dyspnea
Tissue Donors
Bronchiolitis
Liver
Fluorescence In Situ Hybridization
Adrenal Cortex Hormones
Inflammation
Transplants
Biopsy

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Acute graft-versus-host disease of the lung after liver transplantation. / Knox, Kenneth S.; Behnia, Mehrdad; Smith, Lisa R.; Vance, Gail; Busk, Michael; Cummings, Oscar; Kwo, Paul Y.; Wilkes, David S.

In: Liver Transplantation, Vol. 8, No. 10, 01.10.2002, p. 968-971.

Research output: Contribution to journalArticle

Knox, KS, Behnia, M, Smith, LR, Vance, G, Busk, M, Cummings, O, Kwo, PY & Wilkes, DS 2002, 'Acute graft-versus-host disease of the lung after liver transplantation', Liver Transplantation, vol. 8, no. 10, pp. 968-971. https://doi.org/10.1053/jlts.2002.35552
Knox, Kenneth S. ; Behnia, Mehrdad ; Smith, Lisa R. ; Vance, Gail ; Busk, Michael ; Cummings, Oscar ; Kwo, Paul Y. ; Wilkes, David S. / Acute graft-versus-host disease of the lung after liver transplantation. In: Liver Transplantation. 2002 ; Vol. 8, No. 10. pp. 968-971.
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