Abstract
We describe the first case of a man who developed acute graft-versus-host disease (GVHD), isolated to the lung, after an orthotopic liver transplant from a female donor. Our patient experienced dyspnea, worsening hypoxemia, and a progressive obstructive ventilatory defect 12 days after liver transplantation. Open-lung biopsy revealed grade 2 lymphocytic bronchiolitis, the pathologic and immunologic correlate of acute pulmonary GVHD. Fluorescent in situ hybridization confirmed donor cells at sites of peribronchiolar inflammation. High-dose corticosteroids were given with a return to baseline pulmonary function. The current case should alert clinicians to investigate pulmonary GVHD as a potential cause of postoperative dyspnea in liver transplant recipient.
| Original language | English |
|---|---|
| Pages (from-to) | 968-971 |
| Number of pages | 4 |
| Journal | Liver Transplantation |
| Volume | 8 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2002 |
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ASJC Scopus subject areas
- Surgery
- Transplantation
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Acute graft-versus-host disease of the lung after liver transplantation. / Knox, Kenneth S.; Behnia, Mehrdad; Smith, Lisa R.; Vance, Gail; Busk, Michael; Cummings, Oscar; Kwo, Paul Y.; Wilkes, David S.
In: Liver Transplantation, Vol. 8, No. 10, 01.10.2002, p. 968-971.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute graft-versus-host disease of the lung after liver transplantation
AU - Knox, Kenneth S.
AU - Behnia, Mehrdad
AU - Smith, Lisa R.
AU - Vance, Gail
AU - Busk, Michael
AU - Cummings, Oscar
AU - Kwo, Paul Y.
AU - Wilkes, David S.
PY - 2002/10/1
Y1 - 2002/10/1
N2 - We describe the first case of a man who developed acute graft-versus-host disease (GVHD), isolated to the lung, after an orthotopic liver transplant from a female donor. Our patient experienced dyspnea, worsening hypoxemia, and a progressive obstructive ventilatory defect 12 days after liver transplantation. Open-lung biopsy revealed grade 2 lymphocytic bronchiolitis, the pathologic and immunologic correlate of acute pulmonary GVHD. Fluorescent in situ hybridization confirmed donor cells at sites of peribronchiolar inflammation. High-dose corticosteroids were given with a return to baseline pulmonary function. The current case should alert clinicians to investigate pulmonary GVHD as a potential cause of postoperative dyspnea in liver transplant recipient.
AB - We describe the first case of a man who developed acute graft-versus-host disease (GVHD), isolated to the lung, after an orthotopic liver transplant from a female donor. Our patient experienced dyspnea, worsening hypoxemia, and a progressive obstructive ventilatory defect 12 days after liver transplantation. Open-lung biopsy revealed grade 2 lymphocytic bronchiolitis, the pathologic and immunologic correlate of acute pulmonary GVHD. Fluorescent in situ hybridization confirmed donor cells at sites of peribronchiolar inflammation. High-dose corticosteroids were given with a return to baseline pulmonary function. The current case should alert clinicians to investigate pulmonary GVHD as a potential cause of postoperative dyspnea in liver transplant recipient.
UR - http://www.scopus.com/inward/record.url?scp=0036793393&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036793393&partnerID=8YFLogxK
U2 - 10.1053/jlts.2002.35552
DO - 10.1053/jlts.2002.35552
M3 - Article
C2 - 12360443
AN - SCOPUS:0036793393
VL - 8
SP - 968
EP - 971
JO - Liver Transplantation
JF - Liver Transplantation
SN - 1527-6465
IS - 10
ER -