Acute graft-versus-host disease of the lung after liver transplantation

Kenneth S. Knox, Mehrdad Behnia, Lisa R. Smith, Gail H. Vance, Michael Busk, Oscar W. Cummings, Paul Y. Kwo, David S. Wilkes

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We describe the first case of a man who developed acute graft-versus-host disease (GVHD), isolated to the lung, after an orthotopic liver transplant from a female donor. Our patient experienced dyspnea, worsening hypoxemia, and a progressive obstructive ventilatory defect 12 days after liver transplantation. Open-lung biopsy revealed grade 2 lymphocytic bronchiolitis, the pathologic and immunologic correlate of acute pulmonary GVHD. Fluorescent in situ hybridization confirmed donor cells at sites of peribronchiolar inflammation. High-dose corticosteroids were given with a return to baseline pulmonary function. The current case should alert clinicians to investigate pulmonary GVHD as a potential cause of postoperative dyspnea in liver transplant recipient.

Original languageEnglish (US)
Pages (from-to)968-971
Number of pages4
JournalLiver Transplantation
Volume8
Issue number10
DOIs
StatePublished - Oct 1 2002

Fingerprint

Graft vs Host Disease
Liver Transplantation
Lung
Dyspnea
Tissue Donors
Bronchiolitis
Liver
Fluorescence In Situ Hybridization
Adrenal Cortex Hormones
Inflammation
Transplants
Biopsy

ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation

Cite this

Acute graft-versus-host disease of the lung after liver transplantation. / Knox, Kenneth S.; Behnia, Mehrdad; Smith, Lisa R.; Vance, Gail H.; Busk, Michael; Cummings, Oscar W.; Kwo, Paul Y.; Wilkes, David S.

In: Liver Transplantation, Vol. 8, No. 10, 01.10.2002, p. 968-971.

Research output: Contribution to journalArticle

Knox, Kenneth S. ; Behnia, Mehrdad ; Smith, Lisa R. ; Vance, Gail H. ; Busk, Michael ; Cummings, Oscar W. ; Kwo, Paul Y. ; Wilkes, David S. / Acute graft-versus-host disease of the lung after liver transplantation. In: Liver Transplantation. 2002 ; Vol. 8, No. 10. pp. 968-971.
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