Acute Heart Failure Syndromes

Mihai Gheorghiade, Peter S. Pang

Research output: Contribution to journalReview article

401 Scopus citations

Abstract

Heart failure resulting in hospitalization represents a significant and growing health care burden. Heterogeneity characterizes this group in terms of mode of presentation, pathophysiology, and prognosis. The vast majority of patients symptomatically improve during hospitalization; however, their early post-discharge rehospitalization and mortality rates continue to be high. Worsening signs and symptoms, neurohormonal, and renal abnormalities occurring soon after discharge may contribute to these high post-discharge event rates. Currently available assessment modalities combined with recent advances in cardiovascular therapies provide present-day opportunities to improve post-discharge outcomes. Further investigation into pathophysiologic targets and novel approaches to clinical trial design are needed. Improving post-discharge outcomes is the single most important goal in the management of acute heart failure syndromes.

Original languageEnglish (US)
Pages (from-to)557-573
Number of pages17
JournalJournal of the American College of Cardiology
Volume53
Issue number7
DOIs
StatePublished - Feb 17 2009
Externally publishedYes

Keywords

  • acute
  • decompensated
  • failure
  • heart
  • syndromes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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