Acute Heart Failure Syndromes

Mihai Gheorghiade, Peter Pang

Research output: Contribution to journalArticle

395 Citations (Scopus)

Abstract

Heart failure resulting in hospitalization represents a significant and growing health care burden. Heterogeneity characterizes this group in terms of mode of presentation, pathophysiology, and prognosis. The vast majority of patients symptomatically improve during hospitalization; however, their early post-discharge rehospitalization and mortality rates continue to be high. Worsening signs and symptoms, neurohormonal, and renal abnormalities occurring soon after discharge may contribute to these high post-discharge event rates. Currently available assessment modalities combined with recent advances in cardiovascular therapies provide present-day opportunities to improve post-discharge outcomes. Further investigation into pathophysiologic targets and novel approaches to clinical trial design are needed. Improving post-discharge outcomes is the single most important goal in the management of acute heart failure syndromes.

Original languageEnglish (US)
Pages (from-to)557-573
Number of pages17
JournalJournal of the American College of Cardiology
Volume53
Issue number7
DOIs
StatePublished - Feb 17 2009
Externally publishedYes

Fingerprint

Hospitalization
Heart Failure
Signs and Symptoms
Clinical Trials
Delivery of Health Care
Kidney
Mortality
Therapeutics

Keywords

  • acute
  • decompensated
  • failure
  • heart
  • syndromes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Acute Heart Failure Syndromes. / Gheorghiade, Mihai; Pang, Peter.

In: Journal of the American College of Cardiology, Vol. 53, No. 7, 17.02.2009, p. 557-573.

Research output: Contribution to journalArticle

Gheorghiade, Mihai ; Pang, Peter. / Acute Heart Failure Syndromes. In: Journal of the American College of Cardiology. 2009 ; Vol. 53, No. 7. pp. 557-573.
@article{1deea90aea2c435a8059157970e5c59f,
title = "Acute Heart Failure Syndromes",
abstract = "Heart failure resulting in hospitalization represents a significant and growing health care burden. Heterogeneity characterizes this group in terms of mode of presentation, pathophysiology, and prognosis. The vast majority of patients symptomatically improve during hospitalization; however, their early post-discharge rehospitalization and mortality rates continue to be high. Worsening signs and symptoms, neurohormonal, and renal abnormalities occurring soon after discharge may contribute to these high post-discharge event rates. Currently available assessment modalities combined with recent advances in cardiovascular therapies provide present-day opportunities to improve post-discharge outcomes. Further investigation into pathophysiologic targets and novel approaches to clinical trial design are needed. Improving post-discharge outcomes is the single most important goal in the management of acute heart failure syndromes.",
keywords = "acute, decompensated, failure, heart, syndromes",
author = "Mihai Gheorghiade and Peter Pang",
year = "2009",
month = "2",
day = "17",
doi = "10.1016/j.jacc.2008.10.041",
language = "English (US)",
volume = "53",
pages = "557--573",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "7",

}

TY - JOUR

T1 - Acute Heart Failure Syndromes

AU - Gheorghiade, Mihai

AU - Pang, Peter

PY - 2009/2/17

Y1 - 2009/2/17

N2 - Heart failure resulting in hospitalization represents a significant and growing health care burden. Heterogeneity characterizes this group in terms of mode of presentation, pathophysiology, and prognosis. The vast majority of patients symptomatically improve during hospitalization; however, their early post-discharge rehospitalization and mortality rates continue to be high. Worsening signs and symptoms, neurohormonal, and renal abnormalities occurring soon after discharge may contribute to these high post-discharge event rates. Currently available assessment modalities combined with recent advances in cardiovascular therapies provide present-day opportunities to improve post-discharge outcomes. Further investigation into pathophysiologic targets and novel approaches to clinical trial design are needed. Improving post-discharge outcomes is the single most important goal in the management of acute heart failure syndromes.

AB - Heart failure resulting in hospitalization represents a significant and growing health care burden. Heterogeneity characterizes this group in terms of mode of presentation, pathophysiology, and prognosis. The vast majority of patients symptomatically improve during hospitalization; however, their early post-discharge rehospitalization and mortality rates continue to be high. Worsening signs and symptoms, neurohormonal, and renal abnormalities occurring soon after discharge may contribute to these high post-discharge event rates. Currently available assessment modalities combined with recent advances in cardiovascular therapies provide present-day opportunities to improve post-discharge outcomes. Further investigation into pathophysiologic targets and novel approaches to clinical trial design are needed. Improving post-discharge outcomes is the single most important goal in the management of acute heart failure syndromes.

KW - acute

KW - decompensated

KW - failure

KW - heart

KW - syndromes

UR - http://www.scopus.com/inward/record.url?scp=59749099461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59749099461&partnerID=8YFLogxK

U2 - 10.1016/j.jacc.2008.10.041

DO - 10.1016/j.jacc.2008.10.041

M3 - Article

C2 - 19215829

AN - SCOPUS:59749099461

VL - 53

SP - 557

EP - 573

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 7

ER -