Acute IOP elevation with scleral suction

Effects on retrobulbar haemodynamics

Alon Harris, Karen Joos, Matthew Kay, David Evans, Rajesh Shetty, William E. Sponsel, Bruce Martin

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Aims/background - Mechanical and vascular factors may both contribute to glaucoma. This study investigated the relation of mechanical to vascular factors by examining how acute IOP elevation altered flow velocities in the central retinal and ophthalmic arteries. Methods - IOP was elevated from a baseline near 14 to approximately 45 mm Hg using suction ophthalmodynamometry. During recovery from scleral suction, IOP fell to near 8 mm Hg. At each IOP, peak systolic and end diastolic velocities (PSV and EDV) were measured in the central retinal and ophthalmic arteries using colour Doppler imaging (Siemens Quantum 2,000). Eleven healthy people served as subjects. Results - Acute elevation in IOP had no effect upon PSV, EDV, or the derived resistance index in the ophthalmic artery: flow velocities in this vessel were identical at IOP of 8 mm Hg or 45 mm Hg. In contrast, in the central retinal artery, PSV and EDV fell, and the resistance index rose, in steady progression as IOP was acutely elevated (each p < 0.01). At IOP of 45 mm Hg, EDV was virtually absent and the resistance index was very nearly 1.0. Conclusion - Ophthalmic arterial haemodynamics are unrelated to acute fluctuations of the IOP over a wide range, suggesting that ocular hypertension itself cannot induce vascular dysfunction in this artery. In contrast, flow velocities in the central retinal artery were highly IOP dependent, implying that haemodynamic and mechanical factors are closely linked in this vascular bed.

Original languageEnglish
Pages (from-to)1055-1059
Number of pages5
JournalBritish Journal of Ophthalmology
Volume80
Issue number12
StatePublished - Dec 1996

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Retinal Artery
Suction
Ophthalmic Artery
Hemodynamics
Blood Vessels
Ophthalmodynamometry
Ocular Hypertension
Glaucoma
Arteries
Color
vascular factor

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Harris, A., Joos, K., Kay, M., Evans, D., Shetty, R., Sponsel, W. E., & Martin, B. (1996). Acute IOP elevation with scleral suction: Effects on retrobulbar haemodynamics. British Journal of Ophthalmology, 80(12), 1055-1059.

Acute IOP elevation with scleral suction : Effects on retrobulbar haemodynamics. / Harris, Alon; Joos, Karen; Kay, Matthew; Evans, David; Shetty, Rajesh; Sponsel, William E.; Martin, Bruce.

In: British Journal of Ophthalmology, Vol. 80, No. 12, 12.1996, p. 1055-1059.

Research output: Contribution to journalArticle

Harris, A, Joos, K, Kay, M, Evans, D, Shetty, R, Sponsel, WE & Martin, B 1996, 'Acute IOP elevation with scleral suction: Effects on retrobulbar haemodynamics', British Journal of Ophthalmology, vol. 80, no. 12, pp. 1055-1059.
Harris A, Joos K, Kay M, Evans D, Shetty R, Sponsel WE et al. Acute IOP elevation with scleral suction: Effects on retrobulbar haemodynamics. British Journal of Ophthalmology. 1996 Dec;80(12):1055-1059.
Harris, Alon ; Joos, Karen ; Kay, Matthew ; Evans, David ; Shetty, Rajesh ; Sponsel, William E. ; Martin, Bruce. / Acute IOP elevation with scleral suction : Effects on retrobulbar haemodynamics. In: British Journal of Ophthalmology. 1996 ; Vol. 80, No. 12. pp. 1055-1059.
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