Acute Kidney Injury

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Acute kidney injury (AKI), a sudden and sustained decrease in renal function is a common and devastating clinical entity with an increasing incidence and an unacceptably high mortality. Renal ischemia, sepsis, and exposure to a wide variety of toxicants are the most frequent causes of AKI. Chronic renal failure and distant organ effects may be under recognized sequel of AKI. Preventive strategies have been investigated largely for radiocontrast-mediated injury and include hydration, optimizing intravascular volume, and avoiding nephrotoxicants. Although progress has been made, the optimal prescription for renal replacement therapy (dialysis), including timing of initiation, dose, and modality, remain to be determined. Future basic and clinical studies are needed and should identify biomarkers that are altered early in the course of injury and provide prognostic information, effective specific treatments, preventative strategies, and optimal renal replacement therapy.

Original languageEnglish (US)
Title of host publicationRenal Toxicology
PublisherElsevier Inc.
Pages98-127
Number of pages30
Volume14-15
ISBN (Electronic)9780081006122
ISBN (Print)9780081006016
DOIs
StatePublished - Dec 15 2017

Fingerprint

Acute Kidney Injury
Renal Replacement Therapy
Kidney
Wounds and Injuries
Chronic Kidney Failure
Prescriptions
Dialysis
Sepsis
Ischemia
Biomarkers
Mortality
Incidence
Therapeutics

Keywords

  • Aminoglycosides
  • Apoptosis
  • Chronic
  • Endothelium
  • Inflammation mediators
  • Ischemia
  • Kidney failure
  • Kidney tubules
  • Nephrotoxicity
  • Radiocontrast media
  • Renal replacement therapy
  • Sepsis
  • Vascular

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kelly, K. (2017). Acute Kidney Injury. In Renal Toxicology (Vol. 14-15, pp. 98-127). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801238-3.95645-9

Acute Kidney Injury. / Kelly, Katherine.

Renal Toxicology. Vol. 14-15 Elsevier Inc., 2017. p. 98-127.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kelly, K 2017, Acute Kidney Injury. in Renal Toxicology. vol. 14-15, Elsevier Inc., pp. 98-127. https://doi.org/10.1016/B978-0-12-801238-3.95645-9
Kelly K. Acute Kidney Injury. In Renal Toxicology. Vol. 14-15. Elsevier Inc. 2017. p. 98-127 https://doi.org/10.1016/B978-0-12-801238-3.95645-9
Kelly, Katherine. / Acute Kidney Injury. Renal Toxicology. Vol. 14-15 Elsevier Inc., 2017. pp. 98-127
@inbook{191da861791644a4a89a8ae533407a11,
title = "Acute Kidney Injury",
abstract = "Acute kidney injury (AKI), a sudden and sustained decrease in renal function is a common and devastating clinical entity with an increasing incidence and an unacceptably high mortality. Renal ischemia, sepsis, and exposure to a wide variety of toxicants are the most frequent causes of AKI. Chronic renal failure and distant organ effects may be under recognized sequel of AKI. Preventive strategies have been investigated largely for radiocontrast-mediated injury and include hydration, optimizing intravascular volume, and avoiding nephrotoxicants. Although progress has been made, the optimal prescription for renal replacement therapy (dialysis), including timing of initiation, dose, and modality, remain to be determined. Future basic and clinical studies are needed and should identify biomarkers that are altered early in the course of injury and provide prognostic information, effective specific treatments, preventative strategies, and optimal renal replacement therapy.",
keywords = "Aminoglycosides, Apoptosis, Chronic, Endothelium, Inflammation mediators, Ischemia, Kidney failure, Kidney tubules, Nephrotoxicity, Radiocontrast media, Renal replacement therapy, Sepsis, Vascular",
author = "Katherine Kelly",
year = "2017",
month = "12",
day = "15",
doi = "10.1016/B978-0-12-801238-3.95645-9",
language = "English (US)",
isbn = "9780081006016",
volume = "14-15",
pages = "98--127",
booktitle = "Renal Toxicology",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Acute Kidney Injury

AU - Kelly, Katherine

PY - 2017/12/15

Y1 - 2017/12/15

N2 - Acute kidney injury (AKI), a sudden and sustained decrease in renal function is a common and devastating clinical entity with an increasing incidence and an unacceptably high mortality. Renal ischemia, sepsis, and exposure to a wide variety of toxicants are the most frequent causes of AKI. Chronic renal failure and distant organ effects may be under recognized sequel of AKI. Preventive strategies have been investigated largely for radiocontrast-mediated injury and include hydration, optimizing intravascular volume, and avoiding nephrotoxicants. Although progress has been made, the optimal prescription for renal replacement therapy (dialysis), including timing of initiation, dose, and modality, remain to be determined. Future basic and clinical studies are needed and should identify biomarkers that are altered early in the course of injury and provide prognostic information, effective specific treatments, preventative strategies, and optimal renal replacement therapy.

AB - Acute kidney injury (AKI), a sudden and sustained decrease in renal function is a common and devastating clinical entity with an increasing incidence and an unacceptably high mortality. Renal ischemia, sepsis, and exposure to a wide variety of toxicants are the most frequent causes of AKI. Chronic renal failure and distant organ effects may be under recognized sequel of AKI. Preventive strategies have been investigated largely for radiocontrast-mediated injury and include hydration, optimizing intravascular volume, and avoiding nephrotoxicants. Although progress has been made, the optimal prescription for renal replacement therapy (dialysis), including timing of initiation, dose, and modality, remain to be determined. Future basic and clinical studies are needed and should identify biomarkers that are altered early in the course of injury and provide prognostic information, effective specific treatments, preventative strategies, and optimal renal replacement therapy.

KW - Aminoglycosides

KW - Apoptosis

KW - Chronic

KW - Endothelium

KW - Inflammation mediators

KW - Ischemia

KW - Kidney failure

KW - Kidney tubules

KW - Nephrotoxicity

KW - Radiocontrast media

KW - Renal replacement therapy

KW - Sepsis

KW - Vascular

UR - http://www.scopus.com/inward/record.url?scp=85043347418&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043347418&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-801238-3.95645-9

DO - 10.1016/B978-0-12-801238-3.95645-9

M3 - Chapter

AN - SCOPUS:85043347418

SN - 9780081006016

VL - 14-15

SP - 98

EP - 127

BT - Renal Toxicology

PB - Elsevier Inc.

ER -