Acute lung injury: Cellular mechanisms and derangements

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The clinical course of acute lung injury (ALI) is a complex and variable process accompanied by severe lung dysfunction, which persists for a long period of time with variable recovery of pulmonary function. The extent and severity of the lung disease associated with ALI varies with those patients having the most severe manifestations of lung disease being grouped as acute respiratory distress syndrome (ARDS). The pathological injury associated with this disease process, termed diffuse alveolar damage (DAD), has three overlapping phases (exudative, proliferative and fibrotic) which are the consequences of severe injury to the alveolar-capillary unit. There is no uniformity to the progression and length of each stage. This review explores those cellular mechanisms and derangements involved in the progression of ARDS. Those areas that demonstrate the major advances within the field are highlighted because of the diverse and vast nature of the cellular components involved in the process of ALI. We are beginning to identify those processes that contribute to the cellular derangements which are the hallmark of ALI. By expanding our understanding of those factors, we should in the future be able to construct therapeutic interventions that address the aetiology of ALI.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalPaediatric Respiratory Reviews
Volume2
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Acute Lung Injury
Adult Respiratory Distress Syndrome
Lung Diseases
Lung
Recovery of Function
Wounds and Injuries

Keywords

  • Histological phases of ARDS
  • Inflammatory mediators in ARDS
  • Markers for development of ARDS

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Acute lung injury : Cellular mechanisms and derangements. / Schwarz, Margaret.

In: Paediatric Respiratory Reviews, Vol. 2, No. 1, 2001, p. 3-9.

Research output: Contribution to journalArticle

@article{84bc92dc1ec3466fb6876c27dea1c5d8,
title = "Acute lung injury: Cellular mechanisms and derangements",
abstract = "The clinical course of acute lung injury (ALI) is a complex and variable process accompanied by severe lung dysfunction, which persists for a long period of time with variable recovery of pulmonary function. The extent and severity of the lung disease associated with ALI varies with those patients having the most severe manifestations of lung disease being grouped as acute respiratory distress syndrome (ARDS). The pathological injury associated with this disease process, termed diffuse alveolar damage (DAD), has three overlapping phases (exudative, proliferative and fibrotic) which are the consequences of severe injury to the alveolar-capillary unit. There is no uniformity to the progression and length of each stage. This review explores those cellular mechanisms and derangements involved in the progression of ARDS. Those areas that demonstrate the major advances within the field are highlighted because of the diverse and vast nature of the cellular components involved in the process of ALI. We are beginning to identify those processes that contribute to the cellular derangements which are the hallmark of ALI. By expanding our understanding of those factors, we should in the future be able to construct therapeutic interventions that address the aetiology of ALI.",
keywords = "Histological phases of ARDS, Inflammatory mediators in ARDS, Markers for development of ARDS",
author = "Margaret Schwarz",
year = "2001",
doi = "10.1053/prrv.2000.0095",
language = "English (US)",
volume = "2",
pages = "3--9",
journal = "Paediatric Respiratory Reviews",
issn = "1526-0542",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Acute lung injury

T2 - Cellular mechanisms and derangements

AU - Schwarz, Margaret

PY - 2001

Y1 - 2001

N2 - The clinical course of acute lung injury (ALI) is a complex and variable process accompanied by severe lung dysfunction, which persists for a long period of time with variable recovery of pulmonary function. The extent and severity of the lung disease associated with ALI varies with those patients having the most severe manifestations of lung disease being grouped as acute respiratory distress syndrome (ARDS). The pathological injury associated with this disease process, termed diffuse alveolar damage (DAD), has three overlapping phases (exudative, proliferative and fibrotic) which are the consequences of severe injury to the alveolar-capillary unit. There is no uniformity to the progression and length of each stage. This review explores those cellular mechanisms and derangements involved in the progression of ARDS. Those areas that demonstrate the major advances within the field are highlighted because of the diverse and vast nature of the cellular components involved in the process of ALI. We are beginning to identify those processes that contribute to the cellular derangements which are the hallmark of ALI. By expanding our understanding of those factors, we should in the future be able to construct therapeutic interventions that address the aetiology of ALI.

AB - The clinical course of acute lung injury (ALI) is a complex and variable process accompanied by severe lung dysfunction, which persists for a long period of time with variable recovery of pulmonary function. The extent and severity of the lung disease associated with ALI varies with those patients having the most severe manifestations of lung disease being grouped as acute respiratory distress syndrome (ARDS). The pathological injury associated with this disease process, termed diffuse alveolar damage (DAD), has three overlapping phases (exudative, proliferative and fibrotic) which are the consequences of severe injury to the alveolar-capillary unit. There is no uniformity to the progression and length of each stage. This review explores those cellular mechanisms and derangements involved in the progression of ARDS. Those areas that demonstrate the major advances within the field are highlighted because of the diverse and vast nature of the cellular components involved in the process of ALI. We are beginning to identify those processes that contribute to the cellular derangements which are the hallmark of ALI. By expanding our understanding of those factors, we should in the future be able to construct therapeutic interventions that address the aetiology of ALI.

KW - Histological phases of ARDS

KW - Inflammatory mediators in ARDS

KW - Markers for development of ARDS

UR - http://www.scopus.com/inward/record.url?scp=0035018051&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035018051&partnerID=8YFLogxK

U2 - 10.1053/prrv.2000.0095

DO - 10.1053/prrv.2000.0095

M3 - Article

C2 - 16263475

AN - SCOPUS:0035018051

VL - 2

SP - 3

EP - 9

JO - Paediatric Respiratory Reviews

JF - Paediatric Respiratory Reviews

SN - 1526-0542

IS - 1

ER -