Acute mental status change as the presenting feature of adrenal insufficiency in a patient with autoimmune polyglandular syndrome type II and stroke

Sara Watson, Shekar Raj, Erica Eugster, Juan Sanchez

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Primary adrenal insufficiency (AI) in children usually presents with non-specific symptoms such as fatigue, nausea, vomiting, and anorexia. Here, we report an unusual case of a 15 year old girl who presented with acute mental status change and was ultimately diagnosed with AI due to autoimmune polyglandular syndrome type II (APS2). Central nervous system imaging revealed a cerebral infarction. To our knowledge, the constellation of APS2, stroke and acute mental status change has not been previously reported. We review the literature with regard to the presentation of AI as well as the association between vasculitis and APS2.

Original languageEnglish
Pages (from-to)545-548
Number of pages4
JournalJournal of Pediatric Endocrinology and Metabolism
Volume27
Issue number5-6
DOIs
StatePublished - 2014

Fingerprint

Autoimmune Polyendocrinopathies
Adrenal Insufficiency
Stroke
Addison Disease
Cerebral Infarction
Anorexia
Vasculitis
Nausea
Vomiting
Fatigue
Central Nervous System

Keywords

  • Acute mental status change
  • Adrenal insufficiency stroke
  • Autoimmune polyglandular syndrome type 2

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

@article{6cc94a4eac9747fc8b0573f0f5bc77b0,
title = "Acute mental status change as the presenting feature of adrenal insufficiency in a patient with autoimmune polyglandular syndrome type II and stroke",
abstract = "Primary adrenal insufficiency (AI) in children usually presents with non-specific symptoms such as fatigue, nausea, vomiting, and anorexia. Here, we report an unusual case of a 15 year old girl who presented with acute mental status change and was ultimately diagnosed with AI due to autoimmune polyglandular syndrome type II (APS2). Central nervous system imaging revealed a cerebral infarction. To our knowledge, the constellation of APS2, stroke and acute mental status change has not been previously reported. We review the literature with regard to the presentation of AI as well as the association between vasculitis and APS2.",
keywords = "Acute mental status change, Adrenal insufficiency stroke, Autoimmune polyglandular syndrome type 2",
author = "Sara Watson and Shekar Raj and Erica Eugster and Juan Sanchez",
year = "2014",
doi = "10.1515/jpem-2013-0201",
language = "English",
volume = "27",
pages = "545--548",
journal = "Journal of Pediatric Endocrinology and Metabolism",
issn = "0334-018X",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "5-6",

}

TY - JOUR

T1 - Acute mental status change as the presenting feature of adrenal insufficiency in a patient with autoimmune polyglandular syndrome type II and stroke

AU - Watson, Sara

AU - Raj, Shekar

AU - Eugster, Erica

AU - Sanchez, Juan

PY - 2014

Y1 - 2014

N2 - Primary adrenal insufficiency (AI) in children usually presents with non-specific symptoms such as fatigue, nausea, vomiting, and anorexia. Here, we report an unusual case of a 15 year old girl who presented with acute mental status change and was ultimately diagnosed with AI due to autoimmune polyglandular syndrome type II (APS2). Central nervous system imaging revealed a cerebral infarction. To our knowledge, the constellation of APS2, stroke and acute mental status change has not been previously reported. We review the literature with regard to the presentation of AI as well as the association between vasculitis and APS2.

AB - Primary adrenal insufficiency (AI) in children usually presents with non-specific symptoms such as fatigue, nausea, vomiting, and anorexia. Here, we report an unusual case of a 15 year old girl who presented with acute mental status change and was ultimately diagnosed with AI due to autoimmune polyglandular syndrome type II (APS2). Central nervous system imaging revealed a cerebral infarction. To our knowledge, the constellation of APS2, stroke and acute mental status change has not been previously reported. We review the literature with regard to the presentation of AI as well as the association between vasculitis and APS2.

KW - Acute mental status change

KW - Adrenal insufficiency stroke

KW - Autoimmune polyglandular syndrome type 2

UR - http://www.scopus.com/inward/record.url?scp=84902492208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902492208&partnerID=8YFLogxK

U2 - 10.1515/jpem-2013-0201

DO - 10.1515/jpem-2013-0201

M3 - Article

VL - 27

SP - 545

EP - 548

JO - Journal of Pediatric Endocrinology and Metabolism

JF - Journal of Pediatric Endocrinology and Metabolism

SN - 0334-018X

IS - 5-6

ER -