Acute Methylenedioxypyrovalerone Toxicity

Blake A. Froberg, Michael Levine, Michael C. Beuhler, Bryan S. Judge, Philip W. Moore, Kristin M. Engebretsen, Nathanael J. Mckeown, Christopher D. Rosenbaum, Amy C. Young, Daniel Rusyniak

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The objective of this study was to characterize the acute clinical effects, laboratory findings, complications, and disposition of patients presenting to the hospital after abusing synthetic cathinone. We conducted a retrospective multicenter case series of patients with synthetic cathinone abuse by searching for the terms bath salts, MDPV, methylenedioxypyrovalerone, mephedrone, methcathinone, methylone, methedrone, and cathinone within the “agent” field of a national clinical toxicology database (ToxIC). The medical records of these patients were obtained and abstracted by investigators at each study site. Patients with confirmatory testing that identified a synthetic cathinone in either blood or urine were included in the series. Patients who had either an undetectable synthetic cathinone test or no confirmatory testing were excluded. A data abstraction sheet was used to obtain information on each patient. We entered data into an Excel spreadsheet and calculated descriptive statistics. We identified 23 patients with confirmed synthetic cathinone exposure—all were positive for methylenedioxyprovalerone (MDPV). Eighty-three percent were male and 74 % had recreational intent. The most common reported clinical effects were tachycardia (74 %), agitation (65 %), and sympathomimetic syndrome (65 %). Acidosis was the most common laboratory abnormality (43 %). Seventy-eight percent of patients were treated with benzodiazepines and 30 % were intubated. Ninety-six percent of patients were hospitalized and 87 % were admitted to the ICU. The majority (61 %) of patients was discharged home but 30 % required inpatient psychiatric care. There was one death in our series. The majority of patients presenting to the hospital after abusing MDPV have severe sympathomimetic findings requiring hospitalization. A number of these patients require inpatient psychiatric care after their acute presentation.

Original languageEnglish
Pages (from-to)185-194
Number of pages10
JournalJournal of Medical Toxicology
Volume11
Issue number2
DOIs
StatePublished - Dec 3 2014

Fingerprint

Toxicity
Sympathomimetics
Intensive care units
Spreadsheets
Testing
Benzodiazepines
Psychiatry
cathinone
Inpatients
Blood
Salts
Statistics
Acidosis
Baths
Tachycardia
Toxicology
Medical Records
Hospitalization
Research Personnel
Urine

Keywords

  • Central nervous system stimulants
  • Designer drugs
  • Drug effects
  • Poisons
  • Street drugs
  • Toxicology

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Froberg, B. A., Levine, M., Beuhler, M. C., Judge, B. S., Moore, P. W., Engebretsen, K. M., ... Rusyniak, D. (2014). Acute Methylenedioxypyrovalerone Toxicity. Journal of Medical Toxicology, 11(2), 185-194. https://doi.org/10.1007/s13181-014-0446-8

Acute Methylenedioxypyrovalerone Toxicity. / Froberg, Blake A.; Levine, Michael; Beuhler, Michael C.; Judge, Bryan S.; Moore, Philip W.; Engebretsen, Kristin M.; Mckeown, Nathanael J.; Rosenbaum, Christopher D.; Young, Amy C.; Rusyniak, Daniel.

In: Journal of Medical Toxicology, Vol. 11, No. 2, 03.12.2014, p. 185-194.

Research output: Contribution to journalArticle

Froberg, BA, Levine, M, Beuhler, MC, Judge, BS, Moore, PW, Engebretsen, KM, Mckeown, NJ, Rosenbaum, CD, Young, AC & Rusyniak, D 2014, 'Acute Methylenedioxypyrovalerone Toxicity', Journal of Medical Toxicology, vol. 11, no. 2, pp. 185-194. https://doi.org/10.1007/s13181-014-0446-8
Froberg BA, Levine M, Beuhler MC, Judge BS, Moore PW, Engebretsen KM et al. Acute Methylenedioxypyrovalerone Toxicity. Journal of Medical Toxicology. 2014 Dec 3;11(2):185-194. https://doi.org/10.1007/s13181-014-0446-8
Froberg, Blake A. ; Levine, Michael ; Beuhler, Michael C. ; Judge, Bryan S. ; Moore, Philip W. ; Engebretsen, Kristin M. ; Mckeown, Nathanael J. ; Rosenbaum, Christopher D. ; Young, Amy C. ; Rusyniak, Daniel. / Acute Methylenedioxypyrovalerone Toxicity. In: Journal of Medical Toxicology. 2014 ; Vol. 11, No. 2. pp. 185-194.
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