Acute-phase response protein serum amyloid A stimulates renal tubule formation: Studies in vitro and in vivo

Katherine Kelly, Barbara Kluve-Beckerman, Jesus Dominguez

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Serum amyloid A protein (SAA) surges 1,000-fold in the blood of acutephase animals, and yet its function during these acute events remains unknown. We report herein that SAA stimulates a developmental program in cultured NRK-52E cells that culminates in differentiated and functional tubules that feature a proximal tubule phenotype. We also found strong SAA expression in states of tubule formation (in utero stage) and regeneration (recovery from ischemia-reperfusion injury). These data lend support to a novel view of a more localized renal acute-phase reaction, where renal SAA may act as a paracrine or autocrine molecule that promotes tubule formation during development and repair.

Original languageEnglish
JournalAmerican Journal of Physiology - Renal Physiology
Volume296
Issue number6
DOIs
StatePublished - Jun 2009

Fingerprint

Serum Amyloid A Protein
Acute-Phase Reaction
Acute-Phase Proteins
Kidney
Reperfusion Injury
Regeneration
Phenotype
In Vitro Techniques

Keywords

  • Acute kidney injury
  • Kidney development
  • Tubulogenesis

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

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abstract = "Serum amyloid A protein (SAA) surges 1,000-fold in the blood of acutephase animals, and yet its function during these acute events remains unknown. We report herein that SAA stimulates a developmental program in cultured NRK-52E cells that culminates in differentiated and functional tubules that feature a proximal tubule phenotype. We also found strong SAA expression in states of tubule formation (in utero stage) and regeneration (recovery from ischemia-reperfusion injury). These data lend support to a novel view of a more localized renal acute-phase reaction, where renal SAA may act as a paracrine or autocrine molecule that promotes tubule formation during development and repair.",
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AU - Dominguez, Jesus

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AB - Serum amyloid A protein (SAA) surges 1,000-fold in the blood of acutephase animals, and yet its function during these acute events remains unknown. We report herein that SAA stimulates a developmental program in cultured NRK-52E cells that culminates in differentiated and functional tubules that feature a proximal tubule phenotype. We also found strong SAA expression in states of tubule formation (in utero stage) and regeneration (recovery from ischemia-reperfusion injury). These data lend support to a novel view of a more localized renal acute-phase reaction, where renal SAA may act as a paracrine or autocrine molecule that promotes tubule formation during development and repair.

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