Acute-phase response protein serum amyloid A stimulates renal tubule formation: Studies in vitro and in vivo

Katherine J. Kelly, Barbara Kluve-Beckerman, Jesus H. Dominguez

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Serum amyloid A protein (SAA) surges 1,000-fold in the blood of acutephase animals, and yet its function during these acute events remains unknown. We report herein that SAA stimulates a developmental program in cultured NRK-52E cells that culminates in differentiated and functional tubules that feature a proximal tubule phenotype. We also found strong SAA expression in states of tubule formation (in utero stage) and regeneration (recovery from ischemia-reperfusion injury). These data lend support to a novel view of a more localized renal acute-phase reaction, where renal SAA may act as a paracrine or autocrine molecule that promotes tubule formation during development and repair.

Original languageEnglish (US)
Pages (from-to)F1355-F1363
JournalAmerican Journal of Physiology - Renal Physiology
Volume296
Issue number6
DOIs
StatePublished - Jun 1 2009

Keywords

  • Acute kidney injury
  • Kidney development
  • Tubulogenesis

ASJC Scopus subject areas

  • Physiology
  • Urology

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