Acute renal failure in the 21st century: Recommendations for management and outcomes assessment

Thomas D. DuBose, David G. Warnock, Ravindra L. Mehta, Joseph V. Bonventre, Marc R. Hammerman, Bruce Molitoris, Mark S. Paller, Norman J. Siegel, James Scherbenske, Gary E. Striker

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Acute renal failure (ARF) remains a common and potentially devastating disorder affecting as many of 5% of all hospitalized patients, with a higher prevalence in patients in critical care units. ARF is more frequently observed in the setting of multiorgan dysfunction syndrome (MODS) and in elderly patients with complex disease, where mortality is high. Numerous technical advances have not yet impacted favorably on this high mortality rate. This report summarizes recommendations from participants at the National Institutes of Health Conference: 'Acute Renal Failure in the 21st Century,' May 6 to 8, 1996, in Bethesda, MD. The focus is on categorizing recent clinically relevant developments in the field and on identification of new research initiatives to transfer a new body of knowledge derived from fundamental studies and laboratory investigation to the management of ARF in the new millennium. The development of a multicenter database through cooperative multicenter studies is advocated. Future studies should define the appropriate outcome measures to assess and emphasize the impact of hemodynamic monitoring, adjunctive agents, and adequacy and modality of renal replacement therapy on outcomes in ARF.

Original languageEnglish (US)
Pages (from-to)793-799
Number of pages7
JournalAmerican Journal of Kidney Diseases
Volume29
Issue number5
StatePublished - May 1997
Externally publishedYes

Fingerprint

Acute Kidney Injury
Outcome Assessment (Health Care)
Renal Replacement Therapy
Mortality
National Institutes of Health (U.S.)
Critical Care
Multicenter Studies
Hemodynamics
Databases
Research

Keywords

  • Acute renal failure
  • continuous renal replacement therapy
  • critical care unit
  • experimental therapies
  • hemodynamic monitoring
  • intermittent renal replacement therapy

ASJC Scopus subject areas

  • Nephrology

Cite this

DuBose, T. D., Warnock, D. G., Mehta, R. L., Bonventre, J. V., Hammerman, M. R., Molitoris, B., ... Striker, G. E. (1997). Acute renal failure in the 21st century: Recommendations for management and outcomes assessment. American Journal of Kidney Diseases, 29(5), 793-799.

Acute renal failure in the 21st century : Recommendations for management and outcomes assessment. / DuBose, Thomas D.; Warnock, David G.; Mehta, Ravindra L.; Bonventre, Joseph V.; Hammerman, Marc R.; Molitoris, Bruce; Paller, Mark S.; Siegel, Norman J.; Scherbenske, James; Striker, Gary E.

In: American Journal of Kidney Diseases, Vol. 29, No. 5, 05.1997, p. 793-799.

Research output: Contribution to journalArticle

DuBose, TD, Warnock, DG, Mehta, RL, Bonventre, JV, Hammerman, MR, Molitoris, B, Paller, MS, Siegel, NJ, Scherbenske, J & Striker, GE 1997, 'Acute renal failure in the 21st century: Recommendations for management and outcomes assessment', American Journal of Kidney Diseases, vol. 29, no. 5, pp. 793-799.
DuBose, Thomas D. ; Warnock, David G. ; Mehta, Ravindra L. ; Bonventre, Joseph V. ; Hammerman, Marc R. ; Molitoris, Bruce ; Paller, Mark S. ; Siegel, Norman J. ; Scherbenske, James ; Striker, Gary E. / Acute renal failure in the 21st century : Recommendations for management and outcomes assessment. In: American Journal of Kidney Diseases. 1997 ; Vol. 29, No. 5. pp. 793-799.
@article{74795bb4d0c647329a5e40747f0de73b,
title = "Acute renal failure in the 21st century: Recommendations for management and outcomes assessment",
abstract = "Acute renal failure (ARF) remains a common and potentially devastating disorder affecting as many of 5{\%} of all hospitalized patients, with a higher prevalence in patients in critical care units. ARF is more frequently observed in the setting of multiorgan dysfunction syndrome (MODS) and in elderly patients with complex disease, where mortality is high. Numerous technical advances have not yet impacted favorably on this high mortality rate. This report summarizes recommendations from participants at the National Institutes of Health Conference: 'Acute Renal Failure in the 21st Century,' May 6 to 8, 1996, in Bethesda, MD. The focus is on categorizing recent clinically relevant developments in the field and on identification of new research initiatives to transfer a new body of knowledge derived from fundamental studies and laboratory investigation to the management of ARF in the new millennium. The development of a multicenter database through cooperative multicenter studies is advocated. Future studies should define the appropriate outcome measures to assess and emphasize the impact of hemodynamic monitoring, adjunctive agents, and adequacy and modality of renal replacement therapy on outcomes in ARF.",
keywords = "Acute renal failure, continuous renal replacement therapy, critical care unit, experimental therapies, hemodynamic monitoring, intermittent renal replacement therapy",
author = "DuBose, {Thomas D.} and Warnock, {David G.} and Mehta, {Ravindra L.} and Bonventre, {Joseph V.} and Hammerman, {Marc R.} and Bruce Molitoris and Paller, {Mark S.} and Siegel, {Norman J.} and James Scherbenske and Striker, {Gary E.}",
year = "1997",
month = "5",
language = "English (US)",
volume = "29",
pages = "793--799",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "W.B. Saunders Ltd",
number = "5",

}

TY - JOUR

T1 - Acute renal failure in the 21st century

T2 - Recommendations for management and outcomes assessment

AU - DuBose, Thomas D.

AU - Warnock, David G.

AU - Mehta, Ravindra L.

AU - Bonventre, Joseph V.

AU - Hammerman, Marc R.

AU - Molitoris, Bruce

AU - Paller, Mark S.

AU - Siegel, Norman J.

AU - Scherbenske, James

AU - Striker, Gary E.

PY - 1997/5

Y1 - 1997/5

N2 - Acute renal failure (ARF) remains a common and potentially devastating disorder affecting as many of 5% of all hospitalized patients, with a higher prevalence in patients in critical care units. ARF is more frequently observed in the setting of multiorgan dysfunction syndrome (MODS) and in elderly patients with complex disease, where mortality is high. Numerous technical advances have not yet impacted favorably on this high mortality rate. This report summarizes recommendations from participants at the National Institutes of Health Conference: 'Acute Renal Failure in the 21st Century,' May 6 to 8, 1996, in Bethesda, MD. The focus is on categorizing recent clinically relevant developments in the field and on identification of new research initiatives to transfer a new body of knowledge derived from fundamental studies and laboratory investigation to the management of ARF in the new millennium. The development of a multicenter database through cooperative multicenter studies is advocated. Future studies should define the appropriate outcome measures to assess and emphasize the impact of hemodynamic monitoring, adjunctive agents, and adequacy and modality of renal replacement therapy on outcomes in ARF.

AB - Acute renal failure (ARF) remains a common and potentially devastating disorder affecting as many of 5% of all hospitalized patients, with a higher prevalence in patients in critical care units. ARF is more frequently observed in the setting of multiorgan dysfunction syndrome (MODS) and in elderly patients with complex disease, where mortality is high. Numerous technical advances have not yet impacted favorably on this high mortality rate. This report summarizes recommendations from participants at the National Institutes of Health Conference: 'Acute Renal Failure in the 21st Century,' May 6 to 8, 1996, in Bethesda, MD. The focus is on categorizing recent clinically relevant developments in the field and on identification of new research initiatives to transfer a new body of knowledge derived from fundamental studies and laboratory investigation to the management of ARF in the new millennium. The development of a multicenter database through cooperative multicenter studies is advocated. Future studies should define the appropriate outcome measures to assess and emphasize the impact of hemodynamic monitoring, adjunctive agents, and adequacy and modality of renal replacement therapy on outcomes in ARF.

KW - Acute renal failure

KW - continuous renal replacement therapy

KW - critical care unit

KW - experimental therapies

KW - hemodynamic monitoring

KW - intermittent renal replacement therapy

UR - http://www.scopus.com/inward/record.url?scp=12644263391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12644263391&partnerID=8YFLogxK

M3 - Article

C2 - 9159318

AN - SCOPUS:12644263391

VL - 29

SP - 793

EP - 799

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 5

ER -