Acute renal failure: Much more than a kidney disease

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Acute renal failure is a frequent clinical problem with an increasing incidence, an unacceptably high mortality rate that has not improved in more than 40 years, and no specific treatment, yet renal failure is not the usual cause of death. The role of inflammation has been documented in both acute renal injury and cardiac dysfunction. Several investigators have shown that congestive heart failure is associated with increased mortality in patients with acute renal failure. This article reviews some of the cardiac and other distant organ effects of acute renal injury that may be important in the morbidity and mortality observed clinically. Cardiac changes after experimental renal ischemia include cytokine induction, leukocyte infiltration, cell death by apoptosis, and impaired function. I propose that the extrarenal effects of kidney injury must be considered in designing therapies. Acute renal failure has systemic consequences and must be thought of as more than a kidney disease.

Original languageEnglish
Pages (from-to)105-113
Number of pages9
JournalSeminars in Nephrology
Volume26
Issue number2
DOIs
StatePublished - Mar 2006

Fingerprint

Kidney Diseases
Acute Kidney Injury
Mortality
Kidney
Renal Insufficiency
Cause of Death
Leukocytes
Cell Death
Ischemia
Heart Failure
Research Personnel
Apoptosis
Cytokines
Inflammation
Morbidity
Incidence
Wounds and Injuries
Therapeutics

Keywords

  • Acute kidney injury
  • Apoptosis
  • Congestive heart failure
  • Cytokines
  • Leukocytes

ASJC Scopus subject areas

  • Nephrology

Cite this

Acute renal failure : Much more than a kidney disease. / Kelly, Katherine.

In: Seminars in Nephrology, Vol. 26, No. 2, 03.2006, p. 105-113.

Research output: Contribution to journalArticle

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