Acute Rise of Omega-3 Polyunsaturated Fatty Acids During Hemodialysis Treatment

Allon Friedman, Rafat Siddiqui, Bruce A. Watkins

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: Hemodialysis patients have an extremely high rate of cardiac arrhythmia-induced sudden cardiac death, although the risk during the hemodialysis procedure is relatively low. A higher blood content of long-chain omega-3 polyunsaturated fatty acids (PUFAs) is believed to reduce the risk of sudden cardiac death. We performed this study to measure the effect of a single-standard hemodialysis treatment on plasma and erythrocyte omega-3 PUFA levels in chronic hemodialysis patients. Design: This was a prospective, observational study. Setting: The study was performed in one outpatient hemodialysis unit. Patients: Study subjects were all chronic, stable hemodialysis patients. Interventions: There were no interventions. Main Outcome Measures: Plasma and erythrocyte fatty-acid levels were measured before and immediately after a hemodialysis session. Results: Plasma levels of long-chain PUFAs, including the omega-3 fatty acids of interest, all rose, whereas those of shorter-chain or more saturated fatty acids either remained unchanged or fell. A similar trend was seen in erythrocytes, though the results did not reach statistical significance. Conclusions: The hemodialysis procedure induces acute increases of long-chain omega-3 PUFAs in the blood. This effect may help explain why malignant cardiac arrhythmias occur relatively infrequently during hemodialysis.

Original languageEnglish
Pages (from-to)301-303
Number of pages3
JournalJournal of Renal Nutrition
Volume18
Issue number3
DOIs
StatePublished - May 2008

Fingerprint

hemodialysis
Omega-3 Fatty Acids
Unsaturated Fatty Acids
omega-3 fatty acids
Renal Dialysis
erythrocytes
Therapeutics
Erythrocytes
arrhythmia
Sudden Cardiac Death
Cardiac Arrhythmias
Fatty Acids
death
long chain polyunsaturated fatty acids
blood
observational studies
Observational Studies
saturated fatty acids
Rosa
Outpatients

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Urology
  • Food Science
  • Nephrology

Cite this

Acute Rise of Omega-3 Polyunsaturated Fatty Acids During Hemodialysis Treatment. / Friedman, Allon; Siddiqui, Rafat; Watkins, Bruce A.

In: Journal of Renal Nutrition, Vol. 18, No. 3, 05.2008, p. 301-303.

Research output: Contribution to journalArticle

Friedman, Allon ; Siddiqui, Rafat ; Watkins, Bruce A. / Acute Rise of Omega-3 Polyunsaturated Fatty Acids During Hemodialysis Treatment. In: Journal of Renal Nutrition. 2008 ; Vol. 18, No. 3. pp. 301-303.
@article{3aa026f7ed4e48449f47949c1abc6009,
title = "Acute Rise of Omega-3 Polyunsaturated Fatty Acids During Hemodialysis Treatment",
abstract = "Objective: Hemodialysis patients have an extremely high rate of cardiac arrhythmia-induced sudden cardiac death, although the risk during the hemodialysis procedure is relatively low. A higher blood content of long-chain omega-3 polyunsaturated fatty acids (PUFAs) is believed to reduce the risk of sudden cardiac death. We performed this study to measure the effect of a single-standard hemodialysis treatment on plasma and erythrocyte omega-3 PUFA levels in chronic hemodialysis patients. Design: This was a prospective, observational study. Setting: The study was performed in one outpatient hemodialysis unit. Patients: Study subjects were all chronic, stable hemodialysis patients. Interventions: There were no interventions. Main Outcome Measures: Plasma and erythrocyte fatty-acid levels were measured before and immediately after a hemodialysis session. Results: Plasma levels of long-chain PUFAs, including the omega-3 fatty acids of interest, all rose, whereas those of shorter-chain or more saturated fatty acids either remained unchanged or fell. A similar trend was seen in erythrocytes, though the results did not reach statistical significance. Conclusions: The hemodialysis procedure induces acute increases of long-chain omega-3 PUFAs in the blood. This effect may help explain why malignant cardiac arrhythmias occur relatively infrequently during hemodialysis.",
author = "Allon Friedman and Rafat Siddiqui and Watkins, {Bruce A.}",
year = "2008",
month = "5",
doi = "10.1053/j.jrn.2007.11.002",
language = "English",
volume = "18",
pages = "301--303",
journal = "Journal of Renal Nutrition",
issn = "1051-2276",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Acute Rise of Omega-3 Polyunsaturated Fatty Acids During Hemodialysis Treatment

AU - Friedman, Allon

AU - Siddiqui, Rafat

AU - Watkins, Bruce A.

PY - 2008/5

Y1 - 2008/5

N2 - Objective: Hemodialysis patients have an extremely high rate of cardiac arrhythmia-induced sudden cardiac death, although the risk during the hemodialysis procedure is relatively low. A higher blood content of long-chain omega-3 polyunsaturated fatty acids (PUFAs) is believed to reduce the risk of sudden cardiac death. We performed this study to measure the effect of a single-standard hemodialysis treatment on plasma and erythrocyte omega-3 PUFA levels in chronic hemodialysis patients. Design: This was a prospective, observational study. Setting: The study was performed in one outpatient hemodialysis unit. Patients: Study subjects were all chronic, stable hemodialysis patients. Interventions: There were no interventions. Main Outcome Measures: Plasma and erythrocyte fatty-acid levels were measured before and immediately after a hemodialysis session. Results: Plasma levels of long-chain PUFAs, including the omega-3 fatty acids of interest, all rose, whereas those of shorter-chain or more saturated fatty acids either remained unchanged or fell. A similar trend was seen in erythrocytes, though the results did not reach statistical significance. Conclusions: The hemodialysis procedure induces acute increases of long-chain omega-3 PUFAs in the blood. This effect may help explain why malignant cardiac arrhythmias occur relatively infrequently during hemodialysis.

AB - Objective: Hemodialysis patients have an extremely high rate of cardiac arrhythmia-induced sudden cardiac death, although the risk during the hemodialysis procedure is relatively low. A higher blood content of long-chain omega-3 polyunsaturated fatty acids (PUFAs) is believed to reduce the risk of sudden cardiac death. We performed this study to measure the effect of a single-standard hemodialysis treatment on plasma and erythrocyte omega-3 PUFA levels in chronic hemodialysis patients. Design: This was a prospective, observational study. Setting: The study was performed in one outpatient hemodialysis unit. Patients: Study subjects were all chronic, stable hemodialysis patients. Interventions: There were no interventions. Main Outcome Measures: Plasma and erythrocyte fatty-acid levels were measured before and immediately after a hemodialysis session. Results: Plasma levels of long-chain PUFAs, including the omega-3 fatty acids of interest, all rose, whereas those of shorter-chain or more saturated fatty acids either remained unchanged or fell. A similar trend was seen in erythrocytes, though the results did not reach statistical significance. Conclusions: The hemodialysis procedure induces acute increases of long-chain omega-3 PUFAs in the blood. This effect may help explain why malignant cardiac arrhythmias occur relatively infrequently during hemodialysis.

UR - http://www.scopus.com/inward/record.url?scp=41849126777&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41849126777&partnerID=8YFLogxK

U2 - 10.1053/j.jrn.2007.11.002

DO - 10.1053/j.jrn.2007.11.002

M3 - Article

C2 - 18410887

AN - SCOPUS:41849126777

VL - 18

SP - 301

EP - 303

JO - Journal of Renal Nutrition

JF - Journal of Renal Nutrition

SN - 1051-2276

IS - 3

ER -