Acute tubulointerstitial nephritis attributable to indinavir therapy.

M. Jaradat, Carrie Phillips, M. N. Yum, H. Cushing, Sharon Moe

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Indinavir sulfate has been reported to cause asymptomatic crystalluria and nephrolithiasis in patients with human immunodeficiency virus (HIV) infection. Patients taking indinavir may present with asymptomatic crystalluria, nephrolithiasis with frank renal colic and obstruction, flank pain in the absence of nephrolithiasis, and dysuria or urgency. Asymptomatic crystalluria has been described as benign. Discontinuation of the drug has not been recommended in the absence of nephrolithiasis. We report two HIV-positive patients receiving indinavir who developed acute interstitial nephritis with foreign body giant cell reaction on renal biopsies. Both patients had asymptomatic crystalluria, although crystals were associated with clumps of white blood cells (WBCs) on urinalysis in one patient. Both cases show that the inflammatory response was significant enough to lead to tubular injury and acute renal impairment. Our findings suggest that asymptomatic crystalluria attributable to indinavir may illicit an inflammatory response with acute renal insufficiency, warranting monitoring of renal function, especially in patients with crystalluria.

Original languageEnglish
JournalAmerican Journal of Kidney Diseases
Volume35
Issue number4
StatePublished - 2000

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Indinavir
Nephrolithiasis
Acute Kidney Injury
Therapeutics
Foreign Body Giant Cells
HIV
Renal Colic
Kidney
Flank Pain
Dysuria
Interstitial Nephritis
Urinalysis
Virus Diseases
Acute Tubulointerstitial Nephritis
Leukocytes
Biopsy
Pharmaceutical Preparations

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Acute tubulointerstitial nephritis attributable to indinavir therapy. / Jaradat, M.; Phillips, Carrie; Yum, M. N.; Cushing, H.; Moe, Sharon.

In: American Journal of Kidney Diseases, Vol. 35, No. 4, 2000.

Research output: Contribution to journalArticle

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