ADAR editing in double-stranded UTRs and other noncoding RNA sequences

Heather Hundley, Brenda L. Bass

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

ADARs are a family of enzymes, present in all animals, that convert adenosine to inosine within double-stranded RNA (dsRNA). Inosine and adenosine have different base-pairing properties, and thus, editing alters RNA structure, coding potential and splicing patterns. The first ADAR substrates identified were edited in codons, and ADARs were presumed to function primarily in proteome diversification. Although this is an important function of ADARs, especially in the nervous system, editing in coding sequences is rare compared to editing in noncoding sequences. Introns and untranslated regions of mRNA are the primary noncoding targets, but editing also occurs in small RNAs, such as miRNAs. Although the role of editing in noncoding sequences remains unclear, ongoing research suggests functions in the regulation of a variety of post-transcriptional processes.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalTrends in Biochemical Sciences
Volume35
Issue number7
DOIs
StatePublished - Jul 2010

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Untranslated Regions
Inosine
Untranslated RNA
Adenosine
RNA
RNA Editing
Double-Stranded RNA
Neurology
Proteome
MicroRNAs
Codon
Base Pairing
Introns
Nervous System
Animals
Messenger RNA
Substrates
Enzymes
Research

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Medicine(all)

Cite this

ADAR editing in double-stranded UTRs and other noncoding RNA sequences. / Hundley, Heather; Bass, Brenda L.

In: Trends in Biochemical Sciences, Vol. 35, No. 7, 07.2010, p. 377-383.

Research output: Contribution to journalArticle

Hundley, Heather ; Bass, Brenda L. / ADAR editing in double-stranded UTRs and other noncoding RNA sequences. In: Trends in Biochemical Sciences. 2010 ; Vol. 35, No. 7. pp. 377-383.
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