Additive effects of Pre-pregnancy body mass index and gestational diabetes on health outcomes and costs

Valerie E. Whiteman, Jason L. Salemi, Maria C. Mejia De Grubb, Mary Ashley Cain, Mulubrhan F. Mogos, Roger J. Zoorob, Hamisu M. Salihu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective Pre-pregnancy obesity and gestational diabetes mellitus (GDM) are increasingly prevalent independent risk factors for maternal and infant morbidities. However, there is a paucity of information on their joint effects on health outcomes and healthcare costs. Methods A population-based retrospective cohort study was conducted in Florida using a validated statewide database covering 1,057,647 infants born between 2004 and 2009. Using generalized linear modeling, joint associations between levels of pre-pregnancy body mass index (BMI) and GDM and maternal complications of pregnancy, adverse birth outcomes, and healthcare costs were examined. The relative excess risk due to interaction was used to describe the direction and magnitude of the BMI-GDM interaction on the additive scale. Results Increasing pre-pregnancy BMI conferred increasing odds of adverse consequences, as did GDM, and the BMI-GDM interaction was greater than additive for 9 of 14 outcomes. The cost for infants born to women with GDM/obesity-III was 34% higher during the first year compared with those born to women with normal BMI and without GDM. The costs of maternal and infant inpatient care associated with overweight/obesity and GDM totaled over $351 million. Conclusions These findings provide further evidence of the importance of lifestyle modifications to decrease rates of obesity and risk factors from GDM.

Original languageEnglish (US)
Pages (from-to)2299-2308
Number of pages10
JournalObesity
Volume23
Issue number11
DOIs
StatePublished - Nov 1 2015

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Gestational Diabetes
Health Care Costs
Body Mass Index
Pregnancy
Obesity
Surrogate Mothers
Mothers
Infant Care
Costs and Cost Analysis
Pregnancy Complications
Life Style
Inpatients
Cohort Studies
Retrospective Studies
Parturition
Databases
Morbidity

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Whiteman, V. E., Salemi, J. L., Mejia De Grubb, M. C., Ashley Cain, M., Mogos, M. F., Zoorob, R. J., & Salihu, H. M. (2015). Additive effects of Pre-pregnancy body mass index and gestational diabetes on health outcomes and costs. Obesity, 23(11), 2299-2308. https://doi.org/10.1002/oby.21222

Additive effects of Pre-pregnancy body mass index and gestational diabetes on health outcomes and costs. / Whiteman, Valerie E.; Salemi, Jason L.; Mejia De Grubb, Maria C.; Ashley Cain, Mary; Mogos, Mulubrhan F.; Zoorob, Roger J.; Salihu, Hamisu M.

In: Obesity, Vol. 23, No. 11, 01.11.2015, p. 2299-2308.

Research output: Contribution to journalArticle

Whiteman, VE, Salemi, JL, Mejia De Grubb, MC, Ashley Cain, M, Mogos, MF, Zoorob, RJ & Salihu, HM 2015, 'Additive effects of Pre-pregnancy body mass index and gestational diabetes on health outcomes and costs', Obesity, vol. 23, no. 11, pp. 2299-2308. https://doi.org/10.1002/oby.21222
Whiteman VE, Salemi JL, Mejia De Grubb MC, Ashley Cain M, Mogos MF, Zoorob RJ et al. Additive effects of Pre-pregnancy body mass index and gestational diabetes on health outcomes and costs. Obesity. 2015 Nov 1;23(11):2299-2308. https://doi.org/10.1002/oby.21222
Whiteman, Valerie E. ; Salemi, Jason L. ; Mejia De Grubb, Maria C. ; Ashley Cain, Mary ; Mogos, Mulubrhan F. ; Zoorob, Roger J. ; Salihu, Hamisu M. / Additive effects of Pre-pregnancy body mass index and gestational diabetes on health outcomes and costs. In: Obesity. 2015 ; Vol. 23, No. 11. pp. 2299-2308.
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