Adenocarcinoma of the esophagus: Role of obesity and diet

Linda Morris Brown, Christine A. Swanson, Gloria Gridley, G. Marie Swanson, Janet B. Schoenberg, Raymond S. Greenberg, Debra T. Silverman, Linda M. Pottern, Richard B. Hayes, Ann G. Schwartz, Jonathan M. Liff, Joseph F. Fraumeni, Robert N. Hoover

Research output: Contribution to journalArticle

324 Citations (Scopus)

Abstract

Background: In the United States, the incidence of adenocarcinoma of the esophagus, including the esophagogastric junction, has been increasing rapidly over the past two decades. Except for an association with Barrett's esophagus, little is known about the etiology of these cancers. Purpose: Our purpose was to investigate dietary and nutritional risk factors for adenocarcinoma of the esophagus. Methods: A population-based, case-control interview study of 174 white men with adenocarcinoma of the esophagus and 750 control subjects living in three areas of the United States was conducted during 1986 through 1989. Results: Risk was significantly elevated for subjects in the heaviest quartile compared with the lightest quartile of body mass index (adds ratio [OR] = 3.1; 95% confidence interval [CI] = 1.85.3). No significant associations were seen with total calories from food, number of meals eaten per day, level of fat intake, or consumption of coffee and tea. Risks were highest for those consuming the least amount of vegetables, with some evidence of a dose response for the subcategories of cruciferous vegetables (P for trend

Original languageEnglish (US)
Pages (from-to)104-109
Number of pages6
JournalJournal of the National Cancer Institute
Volume87
Issue number2
StatePublished - Jan 18 1995
Externally publishedYes

Fingerprint

Quartile
Obesity
Nutrition
Vegetables
Diet
Dose-response
Case-control Study
Risk Factors
Confidence interval
Esophagogastric Junction
Incidence
Coffee
Cancer
Barrett Esophagus
Tea
Oils and fats
Meals
Case-Control Studies
Body Mass Index
Fats

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging

Cite this

Brown, L. M., Swanson, C. A., Gridley, G., Swanson, G. M., Schoenberg, J. B., Greenberg, R. S., ... Hoover, R. N. (1995). Adenocarcinoma of the esophagus: Role of obesity and diet. Journal of the National Cancer Institute, 87(2), 104-109.

Adenocarcinoma of the esophagus : Role of obesity and diet. / Brown, Linda Morris; Swanson, Christine A.; Gridley, Gloria; Swanson, G. Marie; Schoenberg, Janet B.; Greenberg, Raymond S.; Silverman, Debra T.; Pottern, Linda M.; Hayes, Richard B.; Schwartz, Ann G.; Liff, Jonathan M.; Fraumeni, Joseph F.; Hoover, Robert N.

In: Journal of the National Cancer Institute, Vol. 87, No. 2, 18.01.1995, p. 104-109.

Research output: Contribution to journalArticle

Brown, LM, Swanson, CA, Gridley, G, Swanson, GM, Schoenberg, JB, Greenberg, RS, Silverman, DT, Pottern, LM, Hayes, RB, Schwartz, AG, Liff, JM, Fraumeni, JF & Hoover, RN 1995, 'Adenocarcinoma of the esophagus: Role of obesity and diet', Journal of the National Cancer Institute, vol. 87, no. 2, pp. 104-109.
Brown LM, Swanson CA, Gridley G, Swanson GM, Schoenberg JB, Greenberg RS et al. Adenocarcinoma of the esophagus: Role of obesity and diet. Journal of the National Cancer Institute. 1995 Jan 18;87(2):104-109.
Brown, Linda Morris ; Swanson, Christine A. ; Gridley, Gloria ; Swanson, G. Marie ; Schoenberg, Janet B. ; Greenberg, Raymond S. ; Silverman, Debra T. ; Pottern, Linda M. ; Hayes, Richard B. ; Schwartz, Ann G. ; Liff, Jonathan M. ; Fraumeni, Joseph F. ; Hoover, Robert N. / Adenocarcinoma of the esophagus : Role of obesity and diet. In: Journal of the National Cancer Institute. 1995 ; Vol. 87, No. 2. pp. 104-109.
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