Adenosine is not responsible for local metabolic control of coronary blood flow in dogs during exercise

Johnathan Tune, Keith Neu Richmond, Mark W. Gorman, Ray A. Olsson, Eric O. Feigl

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The purpose of this investigation was to quantitatively evaluate the role of adenosine in coronary exercise hyperemia. Dogs (n = 10) were chronically instrumented with catheters in the aorta and coronary sinus, and a flow probe on the circumflex coronary artery. Cardiac interstitial adenosine concentration was estimated from arterial and coronary venous plasma concentrations using a previously tested mathematical model. Coronary blood flow, myocardial oxygen consumption, heart rate, and aortic pressure were measured at rest and during graded treadmill exercise with and without adenosine receptor blockade with either 8-phenyltheophylline (8-PT) or 8-p- sulfophenyltheophylline (8-PST). In control vehicle dogs, exercise increased myocardial oxygen consumption 4.2-fold, coronary blood flow 3.8-fold, and heart rate 2.5-fold, whereas mean aortic pressure was unchanged. Coronary venous plasma adenosine concentration was little changed with exercise, and the estimated interstitial adenosine concentration remained well below the threshold for coronary vasodilation. Adenosine receptor blockade did not significantly alter myocardial oxygen consumption or coronary blood flow at rest or during exercise. Coronary venous and estimated interstitial adenosine concentration did not increase to overcome the receptor blockade with either 8-PT or 8-PST as would be predicted if adenosine were part of a high-gain, negative-feedback, local metabolic control mechanism. These results demonstrate that adenosine is not responsible for local metabolic control of coronary blood flow in dogs during exercise.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume278
Issue number1 47-1
StatePublished - Jan 2000
Externally publishedYes

Fingerprint

Adenosine
Dogs
Oxygen Consumption
Purinergic P1 Receptors
Arterial Pressure
Heart Rate
Coronary Sinus
Hyperemia
Vasodilation
Aorta
Coronary Vessels
Theoretical Models
Catheters

Keywords

  • 8-phenyltheophylline
  • 8-sulfophenyltheophylline
  • Myocardial blood flow

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Adenosine is not responsible for local metabolic control of coronary blood flow in dogs during exercise. / Tune, Johnathan; Richmond, Keith Neu; Gorman, Mark W.; Olsson, Ray A.; Feigl, Eric O.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 278, No. 1 47-1, 01.2000.

Research output: Contribution to journalArticle

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