Adhesive colonization of biomaterials and antibiotic resistance

Anthony G. Gristina, Cherri D. Hobgood, Lawrence X. Webb, Quentin N. Myrvik

Research output: Contribution to journalArticle

220 Scopus citations


This study addresses the problem of antibiotic resistance in adhesive, biomaterial-centred infections. It is suggested that this anionic, extracapsular, polysaccharide slime produced by bacteria protects them from antibiotics and sequesters critical ions from the surface of biomaterials. Biofilm-enclosed bacteria on the surface of stainless steel substrata in a test chamber were challenged with incremental levels of tobramycin. In this setting, the minimum inhibitory concentration and minimum bactericidal level of tobramycin for Staphylococcus epidermidis were well above normal.

Original languageEnglish (US)
Pages (from-to)423-426
Number of pages4
Issue number6
StatePublished - Nov 1987
Externally publishedYes


  • Implants
  • antibiotic resistance
  • bacterial adhesion
  • biomaterial-centred infection
  • exopolysaccharide

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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